Search Results - Newlands Press

N -heterocyclic carbene-metal complexes as bio-organometallic antimicrobial and anticancer drugs, an update (2015-2020) by A Patil, Siddappa, P Hoagland, Amy, A Patil, Shivaputra, Bugarin, Alejandro

“…-heterocyclic carbenes (NHCs) are organic compounds that typically mimic the chemical properties of phosphines. NHCs have made a significant impact on the…”
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Novel anthraquinone compounds as anticancer agents and their potential mechanism by Tian, Wei, Wang, Chunmiao, Li, Danrong, Hou, Huaxin

“…Anthraquinones exhibit a unique anticancer activity. Since their discovery, medicinal chemists have made several structural modifications, resulting in the…”
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Mechanisms of ebselen as a therapeutic and its pharmacology applications by Wang, Jun, Wang, Peng, Dong, Chuanjiang, Zhao, Ying, Zhou, Jingxuan, Yuan, Chunling, Zou, Lili

“…Ebselen is a synthetic organoselenium radical scavenger compound that possesses glutathione peroxidase-like activity and its own unique bioactivity by reacting…”
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An overview of drug discovery and development by Berdigaliyev, Nurken, Aljofan, Mohamad

“…A new medicine will take an average of 10–15 years and more than US$2 billion before it can reach the pharmacy shelf. Traditionally, drug discovery relied on…”
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An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators by Hu, Yuan-Yuan, Wang, Juan, Li, Tie-Jun, Yadav Bheemanaboina, Rammohan R, Ansari, Mohammad Fawad, Cheng, Yu, Zhou, Cheng-He

“…With the increasing emergence of drug-resistant bacteria, the need for new antimicrobial agents has become extremely urgent. This work was to develop sulfonyl…”
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Polymeric micelles for anticancer drug delivery by Majumder, Nairrita, G Das, Nandita, Das, Sudip K

“…Polymeric micelles have gained interest as novel drug delivery systems for the treatment and diagnosis of cancer, as they offer several advantages over…”
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SGLT2 inhibitors, an accomplished development in field of medicinal chemistry: an extensive review by Manoj, Anirudh, Das, Subham, Kunnath Ramachandran, Anu, Alex, Angel T, Joseph, Alex

“…Diabetes is a chronic progressive metabolic disease caused by insulin deficiency or insulin resistance. In spite of the availability of several…”
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Thiazole in the targeted anticancer drug discovery by Ayati, Adileh, Emami, Saeed, Moghimi, Setareh, Foroumadi, Alireza

“…Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy…”
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N -monosubstituted thiosemicarbazide as novel Ure inhibitors: synthesis, biological evaluation and molecular docking by Ni, Wei-Wei, Fang, Hai-Lian, Ye, Ya-Xi, Li, Wei-Yi, Yuan, Chu-Ping, Li, Dong-Dong, Mao, Shi-Jia, Li, Su-E, Zhu, Qi-Hui, Ouyang, Hui, Xiao, Zhu-Ping, Zhu, Hai-Liang

“…Identification of novel Ure inhibitors with high potency has received considerable attention. Ure inhibition was determined using the indophenol method, the…”
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Antimicrobial innovation: a current update and perspective on the antibiotic drug development pipeline by Stephens, Liam J, Werrett, Melissa V, Sedgwick, Adam C, Bull, Steven D, Andrews, Philip C

“…As bacteria continue to develop resistance to our existing treatment options, antibiotic innovation remains overlooked. If current trends continue, then we…”
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Deep learning for molecular generation by Xu, Youjun, Lin, Kangjie, Wang, Shiwei, Wang, Lei, Cai, Chenjing, Song, Chen, Lai, Luhua, Pei, Jianfeng

“…drug design aims to generate novel chemical compounds with desirable chemical and pharmacological properties from scratch using computer-based methods…”
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Developing cyclic peptide-based drug candidates: an overview by Jin, Kang

“…[...]for most of thecyclic peptides, some pharmacological properties still hobble their development as drug candidates, such as low metabolic stability, poor…”
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Pathway and mechanism of drug binding to chemokine receptors revealed by accelerated molecular simulations by Pawnikar, Shristi, Miao, Yinglong

“…Chemokine GPCRs play key roles in biology and medicine. Particularly, CXCR4 promotes cancer metastasis and facilitate HIV entry into host cells. Plerixafor…”
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Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis by Xing, Jinming, Loureiro, Joseph, Patel, Michael T, Mikhailov, Dmitri, Gusev, Arkady I

“…Evaluation of a novel microsampling device for its use in clinical sample collection and biomarker analysis. Matching samples were collected from 16 healthy…”
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Small-molecule PROTACs: novel agents for cancer therapy by Wan, Yichao, Yan, Chunxing, Gao, Han, Liu, Tingting

“…Proteolysis-targeting chimera (PROTAC) is a new technology to selectively degrade target proteins via ubiquitin-proteasome system. PROTAC molecules (PROTACs)…”
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Mn(II) compounds as an alternative to Gd-based MRI probes by Botta, Mauro, Carniato, Fabio, Esteban-Gómez, David, Platas-Iglesias, Carlos, Tei, Lorenzo

“…Mn(II) has several favorable physicochemical characteristics and a good toxicity profile, which makes it a viable alternative to the Gd(III)-based MRI contrast…”
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Prevention and treatment of radiation-induced lung injury by Xia, Chengcheng, Shi, Weiyan, Zhang, Yuyu, Ding, Lijuan, Gao, Ling, Wang, Qiang, Shao, Lihong, Dong, Lihua, Gao, Yan

“…Radiation-induced lung injury (RILI) is a common complication in cancer patients receiving local thoracic radiation and bone marrow transplantation…”
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The impact and mechanism of ampakine CX1739 on protection against respiratory depression in rats by Xiao, Dian, Xie, Fei, Xu, Xin, Zhou, Xinbo

“…Abuse of analgesic and sedative drugs often leads to severe respiratory depression and sometimes death. Approximately 69,000 people worldwide die annually from…”
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Recent advances of thiazole hybrids in biological applications by Gümüş, Mehmet, Yakan, Mehmet, Koca, İrfan

“…Thiazoles have attracted much synthetic interest due to their wide variety of biological properties and are important members of heterocyclic compounds. In…”
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Recent advances in the development of elastase inhibitors by Donarska, Beata, Z Łączkowski, Krzysztof

“…Due to the fact that a large amount of elastase is released during inflammation, it is involved in the pathogenesis of diseases such as emphysema, chronic…”
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