Search Results - Leoratti, Fabiana M S

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection by Mann, Gurdip Singh, Francisco, Amanda F, Jayawardhana, Shiromani, Taylor, Martin C, Lewis, Michael D, Olmo, Francisco, de Freitas, Elisangela Oliveira, Leoratti, Fabiana M S, López-Camacho, Cesar, Reyes-Sandoval, Arturo, Kelly, John M

“…The long term and complex nature of Chagas disease in humans has restricted studies on vaccine feasibility. Animal models also have limitations due to…”
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Variants in the Toll-Like Receptor Signaling Pathway and Clinical Outcomes of Malaria by Leoratti, Fabiana M. S., Farias, Lilian, Alves, Fabiana P., Suarez-Mútis, Martha C., Coura, José R., Kalil, Jorge, Camargo, Erney P., Moraes, Sandra L, Ramasawmy, Rajendranath

“…Background. Malaria is one of the most significant infectious diseases in the world and is responsible for a large proportion of infant deaths. Toll-like…”
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An unexpected protective role of low-affinity allergen-specific IgG through the inhibitory receptor FcγRIIb by Zha, Lisha, Leoratti, Fabiana M.S., He, Lichun, Mohsen, Mona O., Cragg, Mark, Storni, Federico, Vogel, Monique, Bachmann, Martin F.

“…Induction of allergen-specific IgG antibodies is a critical parameter for successful allergen-specific immunotherapy. IgG antibodies can inhibit IgE-mediated…”
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Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria by Leoratti, Fabiana M S, Durlacher, Rui R, Lacerda, Marcus V G, Alecrim, Maria G, Ferreira, Antonio W, Sanchez, Maria C A, Moraes, Sandra L

“…The development of protective immunity against malaria is slow and to be maintained, it requires exposure to multiple antigenic variants of malaria parasites…”
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RNA and Toll-Like Receptor 7 License the Generation of Superior Secondary Plasma Cells at Multiple Levels in a B Cell Intrinsic Fashion by Krueger, Caroline C, Thoms, Franziska, Keller, Elsbeth, Leoratti, Fabiana M S, Vogel, Monique, Bachmann, Martin F

“…Secondary plasma cells (PCs) originate from memory B cells and produce increased levels of antibodies with higher affinity compared to PCs generated during…”
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The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria by Antonelli, Lis R V, Leoratti, Fabiana M S, Costa, Pedro A C, Rocha, Bruno C, Diniz, Suelen Q, Tada, Mauro S, Pereira, Dhelio B, Teixeira-Carvalho, Andrea, Golenbock, Douglas T, Gonçalves, Ricardo, Gazzinelli, Ricardo T

“…Infection with Plasmodium vivax results in strong activation of monocytes, which are important components of both the systemic inflammatory response and…”
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Early Transcriptional Signature in Dendritic Cells and the Induction of Protective T Cell Responses Upon Immunization With VLPs Containing TLR Ligands-A Role for CCL2 by Gomes, Ariane C, Mohsen, Mona O, Mueller, Julius E, Leoratti, Fabiana M S, Cabral-Miranda, Gustavo, Bachmann, Martin F

“…Inducing T cell responses by therapeutic vaccination requires appropriate activation of antigen presenting cells (APCs). The use of virus-like particles (VLPs)…”
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Evaluation of Chimpanzee Adenovirus and MVA Expressing TRAP and CSP from Plasmodium cynomolgi to Prevent Malaria Relapse in Nonhuman Primates by Kim, Young Chan, Dema, Barbara, Rodriguez-Garcia, Roberto, López-Camacho, César, Leoratti, Fabiana M. S., Lall, Amar, Remarque, Edmond J., Kocken, Clemens H. M., Reyes-Sandoval, Arturo

“…Plasmodium vivax is the world’s most widely distributed human malaria parasite, with over 2.8 billion people at risk in Asia, the Americas, and Africa. The…”
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Virus-Like Particle (VLP) Plus Microcrystalline Tyrosine (MCT) Adjuvants Enhance Vaccine Efficacy Improving T and B Cell Immunogenicity and Protection against Plasmodium berghei/vivax by Cabral-Miranda, Gustavo, Heath, Matthew D, Mohsen, Mona O, Gomes, Ariane C, Engeroff, Paul, Flaxman, Amy, Leoratti, Fabiana M S, El-Turabi, Aadil, Reyes-Sandoval, Arturo, Skinner, Murray A, Kramer, Matthias F, Bachmann, Martin F

“…Vaccination is the most effective prophylactic tool against infectious diseases. Despite continued efforts to control malaria, the disease still generally…”
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Delivering adjuvants and antigens in separate nanoparticles eliminates the need of physical linkage for effective vaccination by Mohsen, Mona O., Gomes, Ariane C., Cabral-Miranda, Gustavo, Krueger, Caroline C., Leoratti, Fabiana MS, Stein, Jens V., Bachmann, Martin F.

“…DNA rich in unmethylated CG motifs (CpGs) engage Toll-Like Receptor 9 (TLR-9) in endosomes and are well described stimulators of the innate and adaptive immune…”
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Induction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine Production by Costa, Pedro A. C., Leoratti, Fabiana M. S., Figueiredo, Maria M., Tada, Mauro S., Pereira, Dhelio B., Junqueira, Caroline, Soares, Irene S., Barber, Daniel L., Gazzinelli, Ricardo T., Antonelli, Lis R. V.

“…The function and regulation of the immune response triggered during malaria is complex and poorly understood, and there is a particular paucity of studies…”
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Differential recognition of Plasmodium falciparum merozoite surface protein 2 variants by antibodies from malaria patients in Brazil by Kanunfre, Kelly A, Leoratti, Fabiana M S, Hoffmann, Erika H E, Durlacher, Rui R, Ferreira, Antônio W, Moraes-Avila, Sandra L, Ferreira, Marcelo U

“…Four variants of merozoite surface protein 2 (MSP-2) of Plasmodium falciparum were used in serology to examine whether changes in repeat units affect its…”
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Cross sectional study reveals a high percentage of asymptomatic Plasmodium vivax infection in the Amazon Rio Negro Area, Brazil by SUAREZ-MUTIS, Martha C, CUERVO, Patricia, LEORATTI, Fabiana M. S, MORAES-AVILA, Sandra L, FERREIRA, Antonio Walter, FERNANDES, Octavio, COURA, José Rodrigues

“…A parasitological, clinical, serological and molecular cross-sectional study carried out in a highly endemic malaria area of Rio Negro in the Amazon State,…”
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The CD14 + CD16 + Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria: e1004393 by Antonelli, Lis RV, Leoratti, Fabiana MS, Costa, Pedro AC, Rocha, Bruno C, Diniz, Suelen Q, Tada, Mauro S, Pereira, Dhelio B, Teixeira-Carvalho, Andrea, Golenbock, Douglas T, Gonçalves, Ricardo, Gazzinelli, Ricardo T

“…Infection with Plasmodium vivax results in strong activation of monocytes, which are important components of both the systemic inflammatory response and…”
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Evaluation of Plasmodium vivax Cell-Traversal Protein for Ookinetes and Sporozoites as a Preerythrocytic P. vivax Vaccine by Alves, Eduardo, Salman, Ahmed M, Leoratti, Fabiana, Lopez-Camacho, Cesar, Viveros-Sandoval, Martha Eva, Lall, Amar, El-Turabi, Aadil, Bachmann, Martin F, Hill, Adrian V S, Janse, Chris J, Khan, Shahid M, Reyes-Sandoval, Arturo

“…Four different vaccine platforms, each targeting the human malaria parasite cell-traversal protein for ookinetes and sporozoites ( CelTOS), were generated and…”
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