Search Results - Lee, Kelvin Y. C

Association of LOXL1 Gene Polymorphisms with Pseudoexfoliation in the Japanese by Ozaki, Mineo, Lee, Kelvin Y. C, Vithana, Eranga N, Yong, Victor H, Thalamuthu, Anbupalam, Mizoguchi, Takanori, Venkatraman, Anandalakshmi, Aung, Tin

“…The single nucleotide polymorphisms (SNPs) rs1048661, rs3825942, and rs2165241 within the LOXL1 gene were recently found to confer risk of pseudoexfoliation…”
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Characterization of Bietti Crystalline Dystrophy Patients with CYP4V2 Mutations by Lee, Kelvin Y. C, Koh, Adrian H. C, Aung, Tin, Yong, Victor H. K, Yeung, Kit, Ang, Chong-Lye, Vithana, Eranga N

“…Mutations of the CYP4V2 gene, a novel family member of the cytochrome P450 genes on chromosome 4q35, have recently been identified in patients with Bietti…”
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Stereotaxy for surgical navigation in orbital surgery by Lee, Kelvin Y C, Ang, Beng Ti, Ng, Ivan, Looi, Audrey

“…Image guidance has been used in neurosurgery with great success. The authors illustrate the use of stereotaxy and neuronavigation in the surgical management of…”
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Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese by Lee, Kelvin Y C, Ho, Su Ling, Thalamuthu, Anbupalam, Venkatraman, Anandalakshmi, Venkataraman, Divya, Pek, Don C K, Aung, Tin, Vithana, Eranga N

“…Single nucleotide polymorphisms (SNPs) within the lysyl oxidase like-1 gene (LOXL1; rs1048661 and rs3825942) were found to confer risk to pseudoexfoliation…”
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Visual recovery following emergent orbital decompression in traumatic retrobulbar haemorrhage by Lee, Kelvin Y C, Tow, Sharon, Fong, Kee-Siew

“…Acute retrobulbar haemorrhage is a potentially sight-threatening condition, and can follow retrobulbar anaesthesia or trauma to the orbit. Acute loss of vision…”
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Modeling Lewy pathology propagation in Parkinson's disease by Luk, Kelvin C, Lee, Virginia M.-Y

“…Summary Lewy bodies (LBs) and Lewy neurites (LNs), comprised of alpha-synuclein (aSyn), are intraneuronal inclusions that characterize Parkinson's disease…”
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Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils by Zhang, Bin, Kehm, Victoria, Gathagan, Ron, Leight, Susan N, Trojanowski, John Q, Lee, Virginia M-Y, Luk, Kelvin C

“…The accumulation of intraneuronal inclusions containing misfolded alpha-synuclein (aSyn) within the central nervous system (CNS) is a common feature found in…”
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Peripapillary atrophy after acute primary angle closure by Lee, Kelvin Y C, Rensch, Florian, Aung, Tin, Lim, Laurence S, Husain, Rahat, Gazzard, Gus, Seah, Steve K L, Jonas, Jost B

“…Aim: To determine the changes in peripapillary atrophy after episodes of acute primary angle closure (APAC). Methods: Prospective observational study of 40…”
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Spectral-domain optical coherence tomography of β-zone peripapillary atrophy: influence of myopia and glaucoma by Hayashi, Keiko, Tomidokoro, Atsuo, Lee, Kelvin Y C, Konno, Shinsuke, Saito, Hitomi, Mayama, Chihiro, Aihara, Makoto, Iwase, Aiko, Araie, Makoto

“…To investigate the influence of glaucoma and myopia on the cross-sectional configuration of the β-zone of peripapillary atrophy (PPA-β) using spectral-domain…”
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Lack of Association between Interleukin-1 Gene Cluster Polymorphisms and Glaucoma in Chinese Subjects by How, Alicia C. S, Aung, Tin, Chew, Xinyi, Yong, Victor H. K, Lim, Marcus C. C, Lee, Kelvin Y. C, Toh, Ju-Yuan, Li, Yuqing, Liu, Jianjun, Vithana, Eranga N

“…A recent study identified single nucleotide polymorphisms (SNPs) within the IL-1 gene cluster at chromosomal locus 2q13 that were associated with reduced risk…”
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Management of Dysphagia in Nursing Homes During the COVID-19 Pandemic: Strategies and Experiences by Fong, Raymond, Tsai, Kelvin C. F., Tong, Michael C. F., Lee, Kathy Y. S.

“…The global 2019 novel coronavirus disease (COVID-19) pandemic has had devastating effects not only on healthcare systems worldwide but also on different…”
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Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease by Rey, Nolwen L, Steiner, Jennifer A, Maroof, Nazia, Luk, Kelvin C, Madaj, Zachary, Trojanowski, John Q, Lee, Virginia M-Y, Brundin, Patrik

“…Parkinson's disease (PD) is characterized by the progressive appearance of intraneuronal Lewy aggregates, which are primarily composed of misfolded α-synuclein…”
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Cell-to-Cell Transmission of Tau and α-Synuclein by Uemura, Norihito, Uemura, Maiko T., Luk, Kelvin C., Lee, Virginia M.-Y., Trojanowski, John Q.

“…The stereotypical spread of pathological protein inclusions and clinicopathological heterogeneity are well described in neurodegenerative diseases…”
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Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death by Volpicelli-Daley, Laura A., Luk, Kelvin C., Patel, Tapan P., Tanik, Selcuk A., Riddle, Dawn M., Stieber, Anna, Meaney, David F., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and…”
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Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates by Volpicelli-Daley, Laura A, Luk, Kelvin C, Lee, Virginia M-Y

“…Lewy bodies and Lewy neurites are found in the brains of patients with Parkinson's disease and other synucleinopathies. This protocol describes how to model…”
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Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term by Rey, Nolwen L., George, Sonia, Steiner, Jennifer A., Madaj, Zachary, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y., Brundin, Patrik

“…Parkinson’s disease is characterized by degeneration of substantia nigra dopamine neurons and by intraneuronal aggregates, primarily composed of misfolded…”
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Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells by Luk, Kelvin C, Song, Cheng, O'Brien, Patrick, Stieber, Anna, Branch, Jonathan R, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M.-Y

“…Cytoplasmic inclusions containing α-synuclein (α-Syn) fibrils, referred to as Lewy bodies (LBs), are the signature neuropathological hallmarks of Parkinson's…”
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Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity by Luk, Kelvin C., Covell, Dustin J., Kehm, Victoria M., Zhang, Bin, Song, Insung Y., Byrne, Matthew D., Pitkin, Rose M., Decker, Samantha C., Trojanowski, John Q., Lee, Virginia M.-Y.

“…The accumulation and propagation of misfolded α-synuclein (α-Syn) is a central feature of Parkinson’s disease and other synucleinopathies. Molecular…”
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Exogenous [alpha]-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death by Volpicelli-Daley, Laura A, Luk, Kelvin C, Patel, Tapan P, Tanik, Selcuk A, Riddle, Dawn M, Stieber, Anna, Meaney, David F, Trojanowski, John Q, Lee, Virginia M-Y

“…Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and…”
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α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice by Uemura, Norihito, Marotta, Nicholas P., Ara, Jahan, Meymand, Emily S., Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails…”
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