Search Results - Impact journals

Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis by Wang, Bolin, Li, Ruobao, Lu, Zhong, Huang, Yan

“…Currently, the number of patients with coronavirus disease 2019 (COVID-19) has increased rapidly, but relationship between comorbidity and patients with…”
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Why does COVID-19 disproportionately affect older people? by Mueller, Amber L, McNamara, Maeve S, Sinclair, David A

“…The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient's age. Adults over 65 years of age represent 80% of…”
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An epigenetic biomarker of aging for lifespan and healthspan by Levine, Morgan E, Lu, Ake T, Quach, Austin, Chen, Brian H, Assimes, Themistocles L, Bandinelli, Stefania, Hou, Lifang, Baccarelli, Andrea A, Stewart, James D, Li, Yun, Whitsel, Eric A, Wilson, James G, Reiner, Alex P, Aviv, Abraham, Lohman, Kurt, Liu, Yongmei, Ferrucci, Luigi, Horvath, Steve

“…Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using…”
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Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis by Fang, Xiaoyu, Li, Shen, Yu, Hao, Wang, Penghao, Zhang, Yao, Chen, Zheng, Li, Yang, Cheng, Liqing, Li, Wenbin, Jia, Hong, Ma, Xiangyu

“…A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity…”
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New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary by Schmauck-Medina, Tomas, Molière, Adrian, Lautrup, Sofie, Zhang, Jianying, Chlopicki, Stefan, Madsen, Helena Borland, Cao, Shuqin, Soendenbroe, Casper, Mansell, Els, Vestergaard, Mark Bitsch, Li, Zhiquan, Shiloh, Yosef, Opresko, Patricia L., Egly, Jean-Marc, Kirkwood, Thomas, Verdin, Eric, Bohr, Vilhelm A., Cox, Lynne S., Stevnsner, Tinna, Rasmussen, Lene Juel, Fang, Evandro F.

“…Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular…”
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DNA methylation GrimAge strongly predicts lifespan and healthspan by Lu, Ake T, Quach, Austin, Wilson, James G, Reiner, Alex P, Aviv, Abraham, Raj, Kenneth, Hou, Lifang, Baccarelli, Andrea A, Li, Yun, Stewart, James D, Whitsel, Eric A, Assimes, Themistocles L, Ferrucci, Luigi, Horvath, Steve

“…It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be…”
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DNA methylation-based estimator of telomere length by Lu, Ake T, Seeboth, Anne, Tsai, Pei-Chien, Sun, Dianjianyi, Quach, Austin, Reiner, Alex P, Kooperberg, Charles, Ferrucci, Luigi, Hou, Lifang, Baccarelli, Andrea A, Li, Yun, Harris, Sarah E, Corley, Janie, Taylor, Adele, Deary, Ian J, Stewart, James D, Whitsel, Eric A, Assimes, Themistocles L, Chen, Wei, Li, Shengxu, Mangino, Massimo, Bell, Jordana T, Wilson, James G, Aviv, Abraham, Marioni, Riccardo E, Raj, Kenneth, Horvath, Steve

“…Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs…”
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LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis by Yang, Xucheng, Yang, Junxiao, Lei, Pengfei, Wen, Ting

“…Long non-coding RNAs (lncRNAs) have emerged as promising novel modulators during osteogenesis in mesenchymal stem cells (MSCs). Enhanced SATB2 has been…”
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Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial by Fitzgerald, Kara N, Hodges, Romilly, Hanes, Douglas, Stack, Emily, Cheishvili, David, Szyf, Moshe, Henkel, Janine, Twedt, Melissa W, Giannopoulou, Despina, Herdell, Josette, Logan, Sally, Bradley, Ryan

“…Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report…”
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Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1 by Dong, Hui, Qiang, Zhuanzhuan, Chai, Dongdong, Peng, Jiali, Xia, Yangyang, Hu, Rong, Jiang, Hong

“…Acute lung injury (ALI) is a syndrome associated with a high mortality rate. Nrf2 is a key regulator of intracellular oxidation homeostasis that plays a…”
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Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis by He, Jianquan, Xu, Shuangbin, Zhang, Bangzhou, Xiao, Chuanxing, Chen, Zhangran, Si, Fuyou, Fu, Jifan, Lin, Xiaomei, Zheng, Guohua, Yu, Guangchuang, Chen, Jian

“…Reduced bone mineral density (BMD) is associated with an altered microbiota in senile osteoporosis. However, the relationship among gut microbiota, BMD and…”
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Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990-2017: results from a global burden of disease study, 2017 by Sun, Hui, Gong, Ting-Ting, Jiang, Yu-Ting, Zhang, Shuang, Zhao, Yu-Hong, Wu, Qi-Jun

“…To provide comprehensive estimates of the global, regional, and national burden of infertility from 1990 to 2017, using findings from a 2017 study on the…”
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Aging and ischemic stroke by Yousufuddin, Mohammed, Young, Nathan

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Mining TCGA database for genes of prognostic value in glioblastoma microenvironment by Jia, Di, Li, Shenglan, Li, Dali, Xue, Haipeng, Yang, Dan, Liu, Ying

“…Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The Cancer Genome Atlas (TCGA) database allows for large-scale global gene…”
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COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? by Sargiacomo, Camillo, Sotgia, Federica, Lisanti, Michael P

“…COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East…”
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Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies by Horvath, Steve, Oshima, Junko, Martin, George M, Lu, Ake T, Quach, Austin, Cohen, Howard, Felton, Sarah, Matsuyama, Mieko, Lowe, Donna, Kabacik, Sylwia, Wilson, James G, Reiner, Alex P, Maierhofer, Anna, Flunkert, Julia, Aviv, Abraham, Hou, Lifang, Baccarelli, Andrea A, Li, Yun, Stewart, James D, Whitsel, Eric A, Ferrucci, Luigi, Matsuyama, Shigemi, Raj, Kenneth

“…DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these biomarkers have sub-optimal accuracy in…”
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Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study by Han, Yi, Zhang, Haidong, Mu, Sucheng, Wei, Wei, Jin, Chaoyuan, Tong, Chaoyang, Song, Zhenju, Zha, Yunfei, Xue, Yuan, Gu, Guorong

“…The World Health Organization has declared coronavirus disease 2019 (COVID-19) a public health emergency of global concern. Updated analysis of cases might…”
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Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death by Liu, Jinglei, Yao, Lei, Zhang, Mingyan, Jiang, Ji, Yang, Maopeng, Wang, Yue

“…LncRNA-XIST participated in the regulation of Non-small cell lung cancer (NSCLC) progression, but the underlying mechanisms are still unclear. This study…”
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ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy by Asselta, Rosanna, Paraboschi, Elvezia Maria, Mantovani, Alberto, Duga, Stefano

“…As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical…”
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lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis by Yang, Yanni, Tai, Wenlin, Lu, Nihong, Li, Ting, Liu, Yongjun, Wu, Wenjuan, Li, Zhengkun, Pu, Lin, Zhao, Xiaoyuan, Zhang, Tao, Dong, Zhaoxing

“…Pulmonary fibrosis (PF) is a lethal fibrotic lung disease. The role of lncRNAs in multiple diseases has been confirmed, but the role and mechanism of lncRNA…”
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