Search Results - GILMER, T. M

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen by Smith, Martin L., I.-Tsuen Chen, Zhan, Qimin, Bae, Insoo, Chen, Chaw-Yuan, Gilmer, Tona M., Kastan, Michael B., O'Connor, Patrick M., Fornace, Albert J.

“…GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21$^{WAF1/CIP1}$,…”
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Growth factor modulation of p53-mediated growth arrest versus apoptosis by Canman, C E, Gilmer, T M, Coutts, S B, Kastan, M B

“…Irradiation of mammalian cells can cause cell cycle perturbations and apoptotic cell death. We have investigated the modulation of these physiologic end points…”
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The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization by Goldman, SC, Chen, CY, Lansing, TJ, Gilmer, TM, Kastan, MB

“…Mutations of the p53 tumor suppressor gene are rarely found in neuroblastoma. Though typically a nuclear protein, a number of tumor cell types have recently…”
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Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb®, GW572016) in an expanded panel of human normal and tumour cell lines by Rusnak, D. W., Alligood, K. J., Mullin, R. J., Spehar, G. M., Arenas-Elliott, C., Martin, A.-M., Degenhardt, Y., Rudolph, S. K., Jr Haws, T. F., Hudson-Curtis, B. L., Gilmer, T. M.

“…  Objective: Lapatinib (Tykerb®, GW572016), a potent inhibitor of the catalytic activities of epidermal growth factor receptor (EGFR) and human epidermal…”
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The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth of Human Normal and Tumor-derived Cell Lines in Vitro and in Vivo by Rusnak, D W, Lackey, K, Affleck, K, Wood, E R, Alligood, K J, Rhodes, N, Keith, B R, Murray, D M, Knight, W B, Mullin, R J, Gilmer, T M

“… and 9.8 n m , respectively. This report describes the efficacy in cell growth assays of GW2016 on human tumor cell lines overexpressing either EGFR or ErbB-2: HN5 (head and neck), A-431 (vulva), BT474 (breast), CaLu-3 (lung), and N87 (gastric…”
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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer by RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J

“…The type I receptor tyrosine kinases constitute a family of transmembrane proteins involved in various aspects of cell growth and survival and have been…”
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Characterization of human Gadd45, a p53-regulated protein by Carrier, F, Smith, M L, Bae, I, Kilpatrick, K E, Lansing, T J, Chen, C Y, Engelstein, M, Friend, S H, Henner, W D, Gilmer, T M

“…GADD45 (growth arrest and DNA damage) is a DNA-damage-inducible gene regulated in part by the tumor suppressor p53. A role in negative growth control has…”
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Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation by Xia, Ling, Wang, Lijuan, Chung, Alicia S, Ivanov, Stanimir S, Ling, Mike Y, Dragoi, Ana M, Platt, Adam, Gilmer, Tona M, Fu, Xin-Yuan, Chin, Y Eugene

“…The cytoplasmic region of human epidermal growth factor receptor (EGFR) contains an intrinsic tyrosine kinase (697–955) followed by a 231-residue-long…”
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ras mutations and expression in head and neck squamous cell carcinomas by Yarbrough, W G, Shores, C, Witsell, D L, Weissler, M C, Fidler, M E, Gilmer, T M

“…Mutational activation and overexpression of the family of ras proto-oncogenes have been associated with many human tumors. The role of mutations of H-ras,…”
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Induction of Gene Amplification by Arsenic by Lee, Te-Chang, Tanaka, Noriho, Lamb, Patricia W., Gilmer, Tona M., Barrett, J. Carl

“…Arsenic is a well-established carcinogen in humans, but there is little evidence for its carcinogenicity in animals and it is inactive as an initiator or tumor…”
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The formation of a covalent complex between a dipeptide ligand and the src SH2 domain by Alligood, Krystal J., Charifson, Paul S., Crosby, Renae, Consler, Thomas G., Feldman, Paul L., Gampe, Robert T., Gilmer, Tona M., Jordan, Steven R., Milstead, Mark W., Mohr, Christopher, Peel, Michael R., Rocque, Warren, Rodriguez, Marc, Rusnak, David W., Shewchuk, Lisa M., Sternbach, Daniel D.

“…The X-ray crystal structure of the src SH2 domain revealed the presence of a thiol residue (Cys 188) located proximal to the phosphotyrosine portion of a…”
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Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate by CHEN, C.-Y. M, HALL, I, LANSING, T. J, GILMER, T. M, TLSTY, T. D, KASTAN, M. B

“…The tumor suppressor gene product, p53, appears to be a significant participant in signaling pathways that mediate cellular responses to cytotoxic stresses. In…”
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Inhibition of the Growth of Patient-Derived Pancreatic Cancer Xenografts with the MEK Inhibitor Trametinib Is Augmented by Combined Treatment with the Epidermal Growth Factor Receptor/HER2 Inhibitor Lapatinib by Walters, Dustin M, Lindberg, James M, Adair, Sara J, Newhook, Timothy E, Cowan, Catharine R, Stokes, Jayme B, Borgman, Cheryl A, Stelow, Edward B, Lowrey, Bryce T, Chopivsky, Maria E, Gilmer, Tona M, Parsons, John T, Bauer, Todd W

“…Abstract Mutations of the oncogene KRAS are important drivers of pancreatic cancer progression. Activation of epidermal growth factor receptor (EGFR) and human…”
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Expression of a fms-Related Oncogene in Carcinogen-Induced Neoplastic Epithelial Cells by Walker, Cheryl, Nettesheim, Paul, Barrett, J. Carl, Gilmer, Tona M.

“…Following carcinogen exposure in vitro, normal rat tracheal epithelial cells are transformed in a multistage process in which the cultured cells become…”
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Involvement of pp60c-src with two major signaling pathways in human breast cancer by LUTTRELL, D. K, LEE, A, LANSING, T. J, CROSBY, R. M, JUNG, K. D, WILLARD, D, LUTHER, M, RODRIGUEZ, M, BERMAN, J, GILMER, T. M

“…The phosphotyrosine residues of receptor tyrosine kinases serve as unique binding sites for proteins involved in intracellular signaling, which contain SRC…”
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Expression of the chicken c-src gene in COS cells [Rous sarcoma virus] by Gilmer, T M

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Differential response to retinoic acid of Syrian hamster embryo fibroblasts expressing v-src or v-Ha-ras oncogenes by JETTEN, A. M, CARL BARRETT, J, GILMER, T. M

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Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers by Clark, G J, Kinch, M S, Gilmer, T M, Burridge, K, Der, C J

“…Although experimental studies suggest that aberrant Ras function can promote the malignant progression of human breast epithelial cells, the occurrence of…”
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Evidence for multiple steps in neoplastic transformation of normal and preneoplastic Syrian hamster embryo cells following transfection with harvey murine sarcoma virus oncogene (v-Ha-ras) by THOMASSEN, D. G, GILMER, T. M, ANNAB, L. A, BARRETT, J. C

“…Neoplastic development of Syrian hamster embryo (SHE) cells in culture is a multistep process in which intermediate or preneoplastic cells can be identified…”
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Neoplastic transformation of normal and carcinogen-induced preneoplastic Syrian hamster embryo cells by the v-src oncogene by Gilmer, T M, Annab, L A, Oshimura, M, Barrett, J C

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