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Current Concepts of Antigen Cross-Presentation by Embgenbroich, Maria, Burgdorf, Sven

“…Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed…”
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Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects by Zhang, Qing-Yu, Wang, Fei-Xuan, Jia, Ke-Ke, Kong, Ling-Dong

“…Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse…”
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On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease by Giguère, Nicolas, Burke Nanni, Samuel, Trudeau, Louis-Eric

“…Significant advances have been made uncovering the factors that render neurons vulnerable in Parkinson's disease (PD). However, the critical pathogenic events…”
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Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases by Wang, Xu, Qiu, Lin, Li, Ziyi, Wang, Xiang-Yang, Yi, Huanfa

“…Neutrophils are one of the first immune cell types that are recruited to injury and infection site. As a vital component of the immune system, neutrophils are…”
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Anakinra Therapy for Non-cancer Inflammatory Diseases by Cavalli, Giulio, Dinarello, Charles A

“…Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a…”
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Motor Control and Sensory Feedback Enhance Prosthesis Embodiment and Reduce Phantom Pain After Long-Term Hand Amputation by Page, David M, George, Jacob A, Kluger, David T, Duncan, Christopher, Wendelken, Suzanne, Davis, Tyler, Hutchinson, Douglas T, Clark, Gregory A

“…We quantified prosthesis embodiment and phantom pain reduction associated with motor control and sensory feedback from a prosthetic hand in one human with a…”
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Endocrine Crosstalk Between Skeletal Muscle and the Brain by Delezie, Julien, Handschin, Christoph

“…Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver,…”
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Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats by Yu, Yiran, Liu, Qiuping, Li, Haichang, Wen, Chengping, He, Zhixing

“…Hyperuricaemia is an important risk factor for many diseases including gout, hypertension, and type II diabetes. The gut microbiota is associated with…”
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Advances in Achieving Opioid Analgesia Without Side Effects by Machelska, Halina, Celik, Melih Ö

“…Opioids are the most effective drugs for the treatment of severe pain, but they also cause addiction and overdose deaths, which have led to a worldwide opioid…”
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From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response? by Cypryk, Wojciech, Nyman, Tuula A, Matikainen, Sampsa

“…Inflammasomes are intracellular protein complexes of pattern recognition receptors and caspase-1, with essential functions in regulating inflammatory responses…”
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Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females by Walker, Deena M, Cunningham, Ashley M, Gregory, Jill K, Nestler, Eric J

“…Adolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both…”
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The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity by Afferni, Claudia, Buccione, Carla, Andreone, Sara, Galdiero, Maria Rosaria, Varricchi, Gilda, Marone, Gianni, Mattei, Fabrizio, Schiavoni, Giovanna

“…Interleukin-33 (IL-33) is a IL-1 family member of cytokines exerting pleiotropic activities. In the steady-state, IL-33 is expressed in the nucleus of…”
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Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson's Disease Mice by Yan, Aijuan, Liu, Zhihua, Song, Lu, Wang, Xijin, Zhang, Yu, Wu, Na, Lin, Jingya, Liu, Ying, Liu, Zhenguo

“…Idebenone is an antioxidant and a coenzyme Q10 analog that has been used to treat neurodegeneration disease. Some studies show idebenone exerts…”
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c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury by Shvedova, Maria, Anfinogenova, Yana, Atochina-Vasserman, Elena N, Schepetkin, Igor A, Atochin, Dmitriy N

“…In this article, we review the literature regarding the role of c-Jun N-terminal kinases (JNKs) in cerebral and myocardial ischemia/reperfusion injury…”
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Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis by Montañez, Maria Isabel, Mayorga, Cristobalina, Bogas, Gador, Barrionuevo, Esther, Fernandez-Santamaria, Ruben, Martin-Serrano, Angela, Laguna, Jose Julio, Torres, Maria José, Fernandez, Tahia Diana, Doña, Inmaculada

“…Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators by mast cells and basophils. Although…”
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Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study by Scatena, Cristian, Roncella, Manuela, Di Paolo, Antonello, Aretini, Paolo, Menicagli, Michele, Fanelli, Giovanni, Marini, Carolina, Mazzanti, Chiara Maria, Ghilli, Matteo, Sotgia, Federica, Lisanti, Michael P, Naccarato, Antonio Giuseppe

“…Cancer stem cells (CSCs) have been implicated in tumor initiation, recurrence, metastatic spread and poor survival in multiple tumor types, breast cancers…”
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Postmortem Toxicology of New Synthetic Opioids by Concheiro, Marta, Chesser, Rachel, Pardi, Justine, Cooper, Gail

“…One hundred fifteen Americans die every day from opioid overdose. These overdose fatalities have been augmented by the increased availability of potent…”
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The Development of an AAV-Based CRISPR SaCas9 Genome Editing System That Can Be Delivered to Neurons in vivo and Regulated via Doxycycline and Cre-Recombinase by Kumar, Namrata, Stanford, William, de Solis, Christopher, Aradhana, Abraham, Nigel D, Dao, Trieu-Mi J, Thaseen, Sadiqa, Sairavi, Anusha, Gonzalez, Cuauhtemoc Ulises, Ploski, Jonathan E

“…The RNA-guided Cas9 nuclease, from the type II prokaryotic clustered regularly interspersed short palindromic repeats (CRISPR) adaptive immune system, has been…”
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Follicular Helper T Cells in Systemic Lupus Erythematosus by Kim, Sun Jung, Lee, Kyungwoo, Diamond, Betty

“…CD4 follicular helper T (Tfh) cells constitute a subset of effector T cells that participate in the generation of high-affinity humoral responses. They express…”
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The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms by Khalil, Radwa, Godde, Ben, Karim, Ahmed A

“…Having a creative mind is one of the gateways for achieving fabulous success and remarkable progress in professional, personal and social life. Therefore, a…”
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