Search Results - FRENKEL, Eugene

Nanoparticles for drug delivery in cancer treatment by Haley, Barbara, M.D, Frenkel, Eugene, M.D

“…Abstract Nanoparticles (size in nanometer range) provide a new mode of cancer drug delivery functioning as a carrier for entry through fenestrations in tumor…”
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Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients by Frankel, Arthur E., Coughlin, Laura A., Kim, Jiwoong, Froehlich, Thomas W., Xie, Yang, Frenkel, Eugene P., Koh, Andrew Y.

“…This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma…”
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Microchip-based immunomagnetic detection of circulating tumor cells by Hoshino, Kazunori, Huang, Yu-Yen, Lane, Nancy, Huebschman, Michael, Uhr, Jonathan W, Frenkel, Eugene P, Zhang, Xiaojing

“…Screening for circulating tumor cells (CTCs) in blood has been an object of interest for evidence of progressive disease, status of disease activity,…”
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The paradoxical effect of bevacizumab in the therapy of malignant gliomas by THOMPSON, Eric M, FRENKEL, Eugene P, NEUWELT, Edward A

“…One rationale behind the use of agents that inhibit vascular endothelial growth factor in the therapy of primary CNS malignancies is based upon the concept…”
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Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset by Mace, Emily M, Hsu, Amy P, Monaco-Shawver, Linda, Makedonas, George, Rosen, Joshua B, Dropulic, Lesia, Cohen, Jeffrey I, Frenkel, Eugene P, Bagwell, John C, Sullivan, John L, Biron, Christine A, Spalding, Christine, Zerbe, Christa S, Uzel, Gulbu, Holland, Steven M, Orange, Jordan S

“…Mutations in the transcription factor GATA2 underlie the syndrome of monocytopenia and B- and natural killer (NK)-cell lymphopenia associated with…”
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Versatile Immunomagnetic Nanocarrier Platform for Capturing Cancer Cells by Wu, Chun-Hsien, Huang, Yu-Yen, Chen, Peng, Hoshino, Kazunori, Liu, Huaying, Frenkel, Eugene P, Zhang, John X. J, Sokolov, Konstantin V

“…Sensitive and quantitative assessment of changes in circulating tumor cells (CTCs) can help in cancer prognosis and in the evaluation of therapeutics efficacy…”
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Circulating Tumor Cells in Patients with Breast Cancer Dormancy by Meng, Songdong, Tripathy, Debasish, Frenkel, Eugene P, Shete, Sanjay, Naftalis, Elizabeth Z, Huth, James F, Beitsch, Peter D, Leitch, Marilyn, Hoover, Susan, Euhus, David, Haley, Barbara, Morrison, Larry, Fleming, Timothy P, Herlyn, Dorothee, Terstappen, Leon W M M, Fehm, Tanja, Tucker, Thomas F, Lane, Nancy, Wang, Jianqiang, Uhr, Jonathan W

“…Purpose: The purpose of this study was to test the hypothesis that circulating tumor cells (CTCs) are present in patients many years after mastectomy without…”
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Clopidogrel anti-platelet effect: An evaluation by optical aggregometry, impedance aggregometry, and the Platelet Function Analyzer (PFA-100™) by Dyszkiewicz-Korpanty, Anna, Olteanu, Horatiu, Frenkel, Eugene P., Sarode, Ravindra

“…Platelet aggregation inhibition by clopidogrel may be suboptimal in 4-30% of patients. Traditionally, optical aggregometry is used to assess clopidogrel's…”
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Analysis of Thrombophilia Test Ordering Practices at an Academic Center: A Proposal for Appropriate Testing to Reduce Harm and Cost by Shen, Yu-Min, Tsai, Judy, Taiwo, Evelyn, Gavva, Chakri, Yates, Sean G, Patel, Vivek, Frenkel, Eugene, Sarode, Ravi

“…Ideally, thrombophilia testing should be tailored to the type of thrombotic event without the influence of anticoagulation therapy or acute phase effects which…”
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Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL by Farrell, Brian T, Hamilton, Bronwyn E, Dósa, Edit, Rimely, Endre, Nasseri, Morad, Gahramanov, Seymur, Lacy, Cynthia A, Frenkel, Eugene P, Doolittle, Nancy D, Jacobs, Paula M, Neuwelt, Edward A

“…OBJECTIVE:The study goal was to assess the benefits and potential limitations in the use of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles in…”
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Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study by Merzon, Eugene, Tworowski, Dmitry, Gorohovski, Alessandro, Vinker, Shlomo, Golan Cohen, Avivit, Green, Ilan, Frenkel‐Morgenstern, Milana

“…Vitamin D deficiency is a worldwide pandemic. The aim of this study was to evaluate associations of plasma 25(OH)D levels with the likelihood of coronavirus…”
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HER-2 Gene Amplification Can Be Acquired as Breast Cancer Progresses by Meng, Songdong, Tripathy, Debasish, Shete, Sanjay, Ashfaq, Raheela, Haley, Barbara, Perkins, Steve, Beitsch, Peter, Khan, Amanullah, Euhus, David, Osborne, Cynthia, Frenkel, Eugene, Hoover, Susan, Leitch, Marilyn, Clifford, Edward, Vitetta, Ellen, Morrison, Larry, Herlyn, Dorothee, Leon W. M. M. Terstappen, Fleming, Timothy, Fehm, Tanja, Tucker, Thomas, Lane, Nancy, Wang, Jianqiang, Uhr, Jonathan

“…Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between primary tumor…”
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Aberrant Promoter Methylation Profile of Prostate Cancers and Its Relationship to Clinicopathological Features by MARUYAMA, Riichiroh, TOYOOKA, Shinichi, TOYOOKA, Kiyomi O, VIRMANI, Arvind K, ZÖCHBAUER-MÜLLER, Sabine, FARINAS, Alfredo J, MINNA, John D, MCCONNELL, John, FRENKEL, Eugene P, GAZDAR, Adi F

“…Purpose: We investigated the aberrant methylation profile of prostate cancers and correlated the data with clinical findings. Experimental Design: Gene…”
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Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5 by Tian, Hui, Lu, Jui-Yun, Shao, Chunli, Huffman, Kenneth E, Carstens, Ryan M, Larsen, Jill E, Girard, Luc, Liu, Hui, Rodriguez-Canales, Jaime, Frenkel, Eugene P, Wistuba, Ignacio I, Minna, John D, Hofmann, Sandra L

“…Protein S-palmitoylation is a widespread and dynamic posttranslational modification that regulates protein-membrane interactions, protein-protein interactions,…”
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Preclinical antitumor activity of S‐222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2 by Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka

“…Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are validated molecular targets in cancer therapy. Dual blockade…”
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Immunomagnetic nanoscreening of circulating tumor cells with a motion controlled microfluidic system by Huang, Yu-yen, Hoshino, Kazunori, Chen, Peng, Wu, Chun-hsien, Lane, Nancy, Huebschman, Michael, Liu, Huaying, Sokolov, Konstantin, Uhr, Jonathan W., Frenkel, Eugene P., Zhang, John X.J.

“…Combining the power of immunomagnetic assay and microfluidic microchip operations, we successfully detected rare CTCs from clinical blood samples. The…”
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Hyperhomocysteinemia and thrombosis by Lee, Ray, Frenkel, Eugene P

“…Homocysteine remains an enigmatic marker for vascular disease. Studies have shown hyperhomocysteinemia is a risk factor for VTE, cerebrovascular disease, and…”
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Thrombosis and a hypercoagulable state in HIV-infected patients by Shen, Yu-Min P, Frenkel, Eugene P

“…Human immunodeficiency virus infection is an illness with protean manifestations including hematological abnormalities. Thromboembolic complications in…”
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Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines by Zhang, Wei, Peyton, Michael, Xie, Yang, Soh, Junichi, Minna, John D, Gazdar, Adi F, Frenkel, Eugene P

“…Most epidermal growth factor receptor (EGFR) mutant non-small cell lung cancers (NSCLCs) are sensitive to EGFR tyrosine kinase inhibitors (TKIs) such as…”
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Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression by Joseph, Richard W, Kapur, Payal, Serie, Daniel J, Parasramka, Mansi, Ho, Thai H, Cheville, John C, Frenkel, Eugene, Parker, Alexander S, Brugarolas, James

“…Purpose In clear cell renal cell carcinoma BAP1 and PBRM1 are 2 of the most commonly mutated genes (10% to 15% and 40% to 50%, respectively). We sought to…”
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