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Comparative bioavailability of betahistine tablet formulations administered in healthy subjects by Val, Ligia, Chen, Lu Shi, Mendes, Gustavo Duarte, Nucci, Gilberte De

“…Abstract Objective: To assess the comparative bioavailability of two formulations (16 mg tablet) of betahistine (CAS 5579-84-0) in healthy volunteers of both…”
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In vitro Antispasmodic and Antiinflammatory Effects of Drosera rotundifolia by Krenn, Liselotte, Beyer, Gabriele, Pertz, Heinz H., Karall, Elisabeth, Kremser, Michaela, Galambosi, Bertalan, Melzig, Matthias F.

“…Summary In investigations of the anti-inflammatory and spasmolytic effects of Drosera rotundifolia two extracts were tested in different in vitro assays. An…”
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Evidence-based intravenous pain treatment with analgesic infusion regimens by Karin, Nemec, Petra, Cihal, Evgeny, Timin, Majid, Kamyar Reza, Rosa, Lemmens-Gruber

“…Abstract Background and objective: To survey all bedside-prepared analgesic infusions (two or more drugs within one vehicle) at a 1000-bed general hospital. To…”
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Synthesis and biological evaluation of some novel quinoxaline derivatives as anticonvulsant agents by Elhelby, Abdelghany Aly, Ayyad, Rezk Rezk, Zayed, Mohamed Fathalla

“…Abstract In view of their expected anticonvulsant activity, some new derivatives of quinon-xaline (V1-7) were designed and synthesized by condensation of…”
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Ameliorative effect of astaxanthin on endothelial dysfunction in streptozotocin-induced diabetes in male rats by Zhao, Zi-Wen, Cai, Wei, Lin, Yun-Ling, Lin, Qing-Fei, Jiang, Qiong, Lin, Zhang, Chen, Liang-Long

“…Abstract The present study was designed to examine whether astaxanthin (ASX, 3,3-dihydroxybeta, beta-carotene-4,4-dione, CAS 472-61-7), a dietary antioxidant…”
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Nitric Oxide-independent Activation of Soluble Guanylate Cyclase by BAY 60-2770 in Experimental Liver Fibrosis by Knorr, Andreas, Hirth-Dietrich, Claudia, Alonso-Alija, Cristina, Härter, Michael, Hahn, Michael, Keim, Yvonne, Wunder, Frank, Stasch, Johannes-Peter

“…Summary Liver cirrhosis is a chronic disease with high mortality rate and need for effective pharmacological intervention. The fibrotic remodelling of liver…”
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Dissociation of Morphine Analgesia and Sedation Evaluated by EEG Measures in Healthy Volunteers by Quante, Markus, Scharein, Ekehard, Zimmermann, Roger, Langer-Brauburger, Birgit, Bromm, Burkhard

“…Summary Aim: The analgesic effects of morphine (CAS 57-27-2) in clinical use are well described. Sedation is discussed as a relevant side-effect, mostly based…”
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Synthesis of some Mannich bases with dimethylamine and their hydrazones and evaluation of their cytotoxicity against Jurkat cells by Kucukoglu, Kaan, Gul, Mustafa, Atalay, Mustafa, Mete, Ebru, Kazaz, Cavit, Hanninen, Osmo, Gul, HaliseInci

“…Abstract 1-Aryl-3-dimethylamino-1-propanone hydrochlorides type mono Mannich bases, D series, and corresponding hydrazone derivatives, K series, were…”
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Determination of the Transdermal Bioavailability of a Newly Developed Diclofenac Sodium Patch in Comparison with a Reference Preparation by Gschwend, Michael H., Martin, Wolfgang, Arnold, Peter, Verdun, Marie-Odile, Cambon, Nathalie, Frentzel, Adrian, Scheiwe, Werner

“…Summary Two different transdermal diclofenac (CAS 15307-86-5) formulations (Olfen ® Patch 140 mg diclofenac sodium as test preparation and 180 mg diclofenac…”
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Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrine by Amelie, Lupp, Dorothea, Appenroth, Lei, Fang, Michael, Decker, Jochen, Lehmann, Christian, Fleck

“…Abstract Tacrine (CAS 321-64-2) is a reversible acetylcholine esterase inhibitor that, despite exerting beneficial effects on Alzheimer’s disease (AD),…”
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Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients by Gupta, Rachna, Bhatia, Jagriti, Gupta, Suresh Kumar

“…Abstract Combination of disease-modifying antirheumatic drugs (DMARDs) is increasingly used in the treatment of rheumatoid arthritis (RA) patients…”
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Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active sulfone moieties with potential anticancer activity by Bashandy, Mahmoud S, Al-Said, Mansour S., Al-Qasoumi, Saleh I., Ghorab, Mostafa M.

“…Abstract This paper describes the synthesis of some novel sulfones having biologically active hydrazides (4-9, 22, 23, 26 and 27), hydrazonoyl cyanide (24),…”
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Simultaneous extraction of acetylsalicylic acid and salicylic acid from human plasma and simultaneous estimation by liquid chromatography and atmospheric pressure chemical ionization/tandem mass spectrometry detection by Nirogi, Ramakrishna, Kandikere, Vishwottam, Mudigonda, Koteshwara, Ajjala, Devender, Suraneni, Ramakrishna, Thoddi, Parthasarathi

“…Abstract A simple analytical method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in atmospheric chemical ionization mode (APCI) for the…”
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Mechanisms Involved in the Anti-inflammatory Effect of a Standardized Willow Bark Extract by Khayyal, Mohamed T., El-Ghazaly, Mona A., Abdallah, Dalal M., Okpanyi, Samuel N., Kelber, Olaf, Weiser, Dieter

“…Summary A standardized willow bark extract (STW 33-I) has been examined to clarify its possible mechanism of action as an anti-inflammatory agent. Various…”
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Physicochemical and toxicological characterization of a new generic iron sucrose preparation by Meier, Thomas, Schropp, Patricia, Pater, Christian, Leoni, Anne-Laure, Khov-Tran, Van Van, Elford, Peter

“…Abstract Intravenous iron preparations are key components in the management of anaemia of various etiologies. These iron-carbohydrate complexes permit safe…”
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Investigation of the Spasmolytic Activity of the Flavonoid Fraction of Achillea millefolium s.l. on Isolated Guinea-pig Ilea by Lemmens-Gruber, Rosa, Marchart, Elke, Rawnduzi, Pakiza, Engel, Nicole, Benedek, Birgit, Kopp, Brigitte

“…Summary The spasmolytic activity of a flavonoid fraction of a commercial sample of yarrow ( Achillea millefolium s.l.), its main flavonoids as well as…”
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Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines by N’Da David, D, Breytenbach Jaco, C, Smith Peter, J, Lategan, Carmen

“…Abstract Series of 4-aminoquinolines bearing an amino side chain linked to the ferrocene moiety through an amide bond were synthesized and evaluated for their…”
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Protective effect of erdosteine metabolite I against hydrogen peroxide-induced oxidative DNA-damage in lung epithelial cells by Marabini, Laura, Calò, Rossella, Braga, Pier Carlo

“…Abstract It has been shown that the mucolytic agent erdosteine (N-carboxymethylthio-acetyl-homocysteine thiolactone, CAS 84611–23–4) has anti-inflammatory and…”
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Interrelations between Diabetes Therapy, Self-Monitoring of Blood Glucose, Blood Glucose and Non-fatal or Fatal Endpoints in Patients with Type 2 Diabetes by Schneider, Berthold, Martin, Stephan, Heinemann, Lutz, Lodwig, Volker, Kolb, Hubert

“…Abstract The ROSSO study is a retrospective, longitudinal cohort study performed to obtain epidemiological data on self-monitoring of blood glucose (SMBG) in…”
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Beneficial effects of colchicine on 17α-ethynylestradiol-induced cholestasis in rats by Zhou, Zhi-Xing, Wang, Tao, Jiang, Zhen-Zhou, Shang, Jing, Liu, Li, Zhang, Yue, Zhu, Dan, Huang, Xiao, Zhang, Shuang, Hu, Yue, Wang, Jia-Ying, Zhang, Lu-Yong

“…Abstract Colchicine (CAS 64-86-8) is considered to have a hepatoprotective effect and play a role in biliary excretion. 17a-Ethynyl-estradiol (EE) (5 mg/kg,…”
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