Search Results - Damm, Georg

A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis by Wallstab, Christin, Eleftheriadou, Dimitra, Schulz, Theresa, Damm, Georg, Seehofer, Daniel, Borlak, Jürgen, Holzhütter, Hermann‐Georg, Berndt, Nikolaus

“…The liver responds to elevated plasma concentrations of free fatty acids (FFAs) with an enhanced uptake of FFAs and their esterification to triacylglycerol…”
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Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis by Gaul, Susanne, Leszczynska, Aleksandra, Alegre, Fernando, Kaufmann, Benedikt, Johnson, Casey D., Adams, Leon A., Wree, Alexander, Damm, Georg, Seehofer, Daniel, Calvente, Carolina J., Povero, Davide, Kisseleva, Tatiana, Eguchi, Akiko, McGeough, Matthew D., Hoffman, Hal M., Pelegrin, Pablo, Laufs, Ulrich, Feldstein, Ariel E.

“…Increased hepatocyte death contributes to the pathology of acute and chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular…”
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Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis by Seidemann, Lena, Krüger, Anne, Kegel-Hübner, Victoria, Seehofer, Daniel, Damm, Georg

“…Nonalcoholic fatty liver disease (NAFLD) is among the leading causes of end-stage liver disease. The impaired hepatic lipid metabolism in NAFLD is exhibited by…”
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A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells by Klein, Marcus, Thomas, Maria, Hofmann, Ute, Seehofer, Daniel, Damm, Georg, Zanger, Ulrich M

“…Inflammatory processes are associated with compromised metabolism and elimination of drugs in the liver, largely mediated by proinflammatory cytokines, such as…”
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Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control by Brosch, Mario, Kattler, Kathrin, Herrmann, Alexander, von Schönfels, Witigo, Nordström, Karl, Seehofer, Daniel, Damm, Georg, Becker, Thomas, Zeissig, Sebastian, Nehring, Sophie, Reichel, Fabian, Moser, Vincent, Thangapandi, Raghavan Veera, Stickel, Felix, Baretton, Gustavo, Röcken, Christoph, Muders, Michael, Matz-Soja, Madlen, Krawczak, Michael, Gasparoni, Gilles, Hartmann, Hella, Dahl, Andreas, Schafmayer, Clemens, Walter, Jörn, Hampe, Jochen

“…A deeper epigenomic understanding of spatial organization of cells in human tissues is an important challenge. Here we report the first combined positional…”
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Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells by Pfeiffer, Elisa, Kegel, Victoria, Zeilinger, Katrin, Hengstler, Jan G, Nüssler, Andreas K, Seehofer, Daniel, Damm, Georg

“…Primary human hepatocytes (PHH) are considered to be the gold standard for in vitro testing of xenobiotic metabolism and hepatotoxicity. However, PHH…”
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Prolonged Lipid Accumulation in Cultured Primary Human Hepatocytes Rather Leads to ER Stress than Oxidative Stress by Rennert, Christiane, Heil, Theresa, Schicht, Gerda, Stilkerich, Anna, Seidemann, Lena, Kegel-Hübner, Victoria, Seehofer, Daniel, Damm, Georg

“…Overweight has become a major health care problem in Western societies and is accompanied by an increasing incidence and prevalence of non-alcoholic fatty…”
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Cell atlas of the regenerating human liver after portal vein embolization by Brazovskaja, Agnieska, Gomes, Tomás, Holtackers, Rene, Wahle, Philipp, Körner, Christiane, He, Zhisong, Schaffer, Theresa, Eckel, Julian Connor, Hänsel, René, Santel, Malgorzata, Seimiya, Makiko, Denecke, Timm, Dannemann, Michael, Brosch, Mario, Hampe, Jochen, Seehofer, Daniel, Damm, Georg, Camp, J. Gray, Treutlein, Barbara

“…The liver has the remarkable capacity to regenerate. In the clinic, regeneration is induced by portal vein embolization, which redirects portal blood flow,…”
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Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype by Fayyaz, Susann, Henkel, Janin, Japtok, Lukasz, Krämer, Stephanie, Damm, Georg, Seehofer, Daniel, Püschel, Gerhard P., Kleuser, Burkhard

“…Aims/hypothesis Enhanced plasma levels of NEFA have been shown to induce hepatic insulin resistance, which contributes to the development of type 2 diabetes…”
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Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction by Kok, Frédérique, Rosenblatt, Marcus, Teusel, Melissa, Nizharadze, Tamar, Gonçalves Magalhães, Vladimir, Dächert, Christopher, Maiwald, Tim, Vlasov, Artyom, Wäsch, Marvin, Tyufekchieva, Silvana, Hoffmann, Katrin, Damm, Georg, Seehofer, Daniel, Boettler, Tobias, Binder, Marco, Timmer, Jens, Schilling, Marcel, Klingmüller, Ursula

“…Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon…”
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Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease by Burbano de Lara, Sebastian, Kemmer, Svenja, Biermayer, Ina, Feiler, Svenja, Vlasov, Artyom, D’Alessandro, Lorenza A, Helm, Barbara, Mölders, Christina, Dieter, Yannik, Ghallab, Ahmed, Hengstler, Jan G, Körner, Christiane, Matz-Soja, Madlen, Götz, Christina, Damm, Georg, Hoffmann, Katrin, Seehofer, Daniel, Berg, Thomas, Schilling, Marcel, Timmer, Jens, Klingmüller, Ursula

“…Chronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, metabolic dysfunction-associated…”
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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue by Godoy, Patricio, Widera, Agata, Schmidt-Heck, Wolfgang, Campos, Gisela, Meyer, Christoph, Cadenas, Cristina, Reif, Raymond, Stöber, Regina, Hammad, Seddik, Pütter, Larissa, Gianmoena, Kathrin, Marchan, Rosemarie, Ghallab, Ahmed, Edlund, Karolina, Nüssler, Andreas, Thasler, Wolfgang E., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Dirsch, Olaf, Dahmen, Uta, Gebhardt, Rolf, Chaudhari, Umesh, Meganathan, Kesavan, Sachinidis, Agapios, Kelm, Jens, Hofmann, Ute, Zahedi, René P., Guthke, Reinhard, Blüthgen, Nils, Dooley, Steven, Hengstler, Jan G.

“…It is well known that isolation and cultivation of primary hepatocytes cause major gene expression alterations. In the present genome-wide, time-resolved study…”
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Toxicogenomics directory of chemically exposed human hepatocytes by Grinberg, Marianna, Stöber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Jürgen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nüssler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, Marcel, Rahnenführer, Jörg, Hengstler, Jan G.

“…A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. Often, transcriptomics data are used…”
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Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria by Gianmoena, Kathrin, Gasparoni, Nina, Jashari, Adelina, Gabrys, Philipp, Grgas, Katharina, Ghallab, Ahmed, Nordström, Karl, Gasparoni, Gilles, Reinders, Jörg, Edlund, Karolina, Godoy, Patricio, Schriewer, Alexander, Hayen, Heiko, Hudert, Christian A., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Boor, Peter, Anders, Hans-Joachim, Motrapu, Manga, Jansen, Peter, Schiergens, Tobias S., Falk-Paulsen, Maren, Rosenstiel, Philip, Lisowski, Clivia, Salido, Eduardo, Marchan, Rosemarie, Walter, Jörn, Hengstler, Jan G., Cadenas, Cristina

“…Epigenetic modifications (e.g. DNA methylation) in NAFLD and their contribution to disease progression and extrahepatic complications are poorly explored…”
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Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin by Roser, Luise A, Luckhardt, Sonja, Ziegler, Nicole, Thomas, Dominique, Wagner, Pia Viktoria, Damm, Georg, Scheffschick, Andrea, Hewitt, Philip, Parnham, Michael J, Schiffmann, Susanne

“…Hepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to…”
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Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity by Ruoß, Marc, Damm, Georg, Vosough, Massoud, Ehret, Lisa, Grom-Baumgarten, Carl, Petkov, Martin, Naddalin, Silvio, Ladurner, Ruth, Seehofer, Daniel, Nussler, Andreas, Sajadian, Sahar

“…Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests…”
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Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα) by Thomas, Maria, Burk, Oliver, Klumpp, Britta, Kandel, Benjamin A, Damm, Georg, Weiss, Thomas S, Klein, Kathrin, Schwab, Matthias, Zanger, Ulrich M

“…The nuclear receptor peroxisome proliferator-activated receptor (PPAR)α is known primarily as a regulator of fatty acid metabolism, energy balance, and…”
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Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system by Freyer, Nora, Knöspel, Fanny, Damm, Georg, Greuel, Selina, Schneider, Christin, Seehofer, Daniel, Stöhr, Thomas, Petersen, Karl-Uwe, Zeilinger, Katrin

“…Remimazolam is an ultra-short acting benzodiazepine under development for procedural sedation and general anesthesia. It is hydrolyzed by CES1 to an inactive…”
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Optimization of extracellular matrix for primary human hepatocyte cultures using mixed collagen-Matrigel matrices by Seidemann, Lena, Prinz, Sarah, Scherbel, Jan-Constantin, Götz, Christina, Seehofer, Daniel, Damm, Georg

“…Loss of differentiation of primary human hepatocytes (PHHs) is a known problem of liver models. Culture optimizations using collagen type I and Matrigel reduce…”
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Hemolysis after Oral Artemisinin Combination Therapy for Uncomplicated Plasmodium falciparum Malaria by Kurth, Florian, Lingscheid, Tilman, Steiner, Florian, Stegemann, Miriam S, Bélard, Sabine, Menner, Nikolai, Pongratz, Peter, Kim, Johanna, von Bernuth, Horst, Mayer, Beate, Damm, Georg, Seehofer, Daniel, Salama, Abdulgabar, Suttorp, Norbert, Zoller, Thomas

“…Episodes of delayed hemolysis 2-6 weeks after treatment of severe malaria with intravenous artesunate have been described. We performed a prospective…”
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