Search Results - BMJ Publishing Group Ltd and Association of Clinical Pathologists

EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples by Ellison, Gillian, Zhu, Guanshan, Moulis, Alexandros, Dearden, Simon, Speake, Georgina, McCormack, Rose

“…Activating mutations in the gene encoding epidermal growth factor receptor (EGFR) can confer sensitivity to EGFR tyrosine kinase inhibitors such as gefitinib…”
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Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype by Ricardo, Sara, Vieira, André Filipe, Gerhard, Renê, Leitão, Dina, Pinto, Regina, Cameselle-Teijeiro, Jorge F, Milanezi, Fernanda, Schmitt, Fernando, Paredes, Joana

“…The study of CD44/CD24 and ALDH1 expression is the most accurate method to identify cancer stem cells (CSC) from breast cancer populations. However, the…”
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Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing by Conde, Esther, Rojo, Federico, Gómez, Javier, Enguita, Ana Belén, Abdulkader, Ihab, González, Ana, Lozano, Dolores, Mancheño, Nuria, Salas, Clara, Salido, Marta, Salido-Ruiz, Eduardo, de Álava, Enrique

“…The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends on the accurate determination of the…”
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Thyroid autoantibodies by Dwivedi, Shivangi Nikhil, Kalaria, Tejas, Buch, Harit

“…Thyroid-stimulating hormone (TSH) receptor antibody (TSH-R-Ab or TRAb) testing plays a pivotal role in arriving at the aetiological diagnosis in patients with…”
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Vitamin D: a negative acute phase reactant by Waldron, Jenna Louise, Ashby, Helen L, Cornes, Michael P, Bechervaise, Julia, Razavi, Cyrus, Thomas, Osmond L, Chugh, Sanjiv, Deshpande, Shreeram, Ford, Clare, Gama, Rousseau

“…We evaluated the effect of the systemic inflammatory response (SIR), as provoked by elective orthopaedic surgery, on serum vitamin D [25-(OH)D]. Serum…”
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Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis by Holland, David, Heald, Adrian H, Stedman, Mike, Hanna, Fahmy, Wu, Pensee, Duff, Christopher, Green, Lewis, Robinson, Sarah, Halsall, Ian, Gaskell, Neil, Pemberton, John, Bloor, Christine, Fryer, Anthony A

“…The COVID-19 pandemic, and the focus on mitigating its effects, has disrupted diabetes healthcare services worldwide. We aimed to quantify the effect of the…”
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Mid-regional proadrenomedullin (MR-proADM), C-reactive protein (CRP) and other biomarkers in the early identification of disease progression in patients with COVID-19 in the acute NHS setting by Moore, Nathan, Williams, Rebecca, Mori, Matilde, Bertolusso, Beatrice, Vernet, Gabrielle, Lynch, Jessica, Philipson, Pete, Ledgerwood, Thomas, Kidd, Stephen P, Thomas, Claire, Garcia-Arias, Veronica, Young, Michelle, Saeed, Kordo, Gordon, Kirsty, Cortes, Nicholas

“…There is a lack of biomarkers validated for assessing clinical deterioration in patients with COVID-19 on presentation to secondary or tertiary care. This…”
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In-house homologous recombination deficiency testing in ovarian cancer: a multi-institutional Italian pilot study by Pepe, Francesco, Guerini-Rocco, Elena, Fassan, Matteo, Fusco, Nicola, Vacirca, Davide, Ranghiero, Alberto, Venetis, Konstantinos, Rappa, Alessandra, Taormina, Sergio Vincenzo, Russo, Gianluca, Rebellato, Elena, Munari, Giada, Moreno-Manuel, Andrea, De Angelis, Carmine, Zamagni, Claudio, Valabrega, Giorgio, Malapelle, Umberto, Troncone, Giancarlo, Barberis, Massimo, Iaccarino, Antonino

“…Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPIs) represent a standard of care for the clinical management of high-grade serous ovarian cancer (HGSOC)…”
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Tumour-infiltrating macrophages and clinical outcome in breast cancer by Mahmoud, S M A, Lee, A H S, Paish, E C, Macmillan, R D, Ellis, I O, Green, A R

“…Macrophages constitute a major component of the leucocytic infiltrate of tumours. Human studies show an association between tumour-associated macrophages and…”
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Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma by Ye, Qiqi, Chen, Hui, Han, Cody, Peng, Yan, Huang, Xiao, Sun, Hongxia, Wu, Yun, Albarracin, Constance T, Middleton, Lavinia P, Sahin, Aysegul A, Huo, Lei, Ding, Qingqing

“…Secretory carcinoma of breast (SCB) typically harbours gene fusion. Pan-Trk immunohistochemistry analysis (IHC) has been shown to be sensitive for SCB…”
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Molecular characterisation of pancreatic ductal adenocarcinoma with NTRK fusions and review of the literature by Allen, Michael J, Zhang, Amy, Bavi, Prashant, Kim, Jaeseung C, Jang, Gun Ho, Kelly, Deirdre, Perera, Sheron, Denroche, Rob E, Notta, Faiyaz, Wilson, Julie M, Dodd, Anna, Ramotar, Stephanie, Hutchinson, Shawn, Fischer, Sandra E, Grant, Robert C, Gallinger, Steven, Knox, Jennifer J, O'Kane, Grainne M

“…The majority of pancreatic ductal adenocarcinomas (PDACs) harbour oncogenic mutations in with variants in , and also prevalent. The presence of oncogenic…”
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Best practice for LDL-cholesterol: when and how to calculate by Martins, Janine, Steyn, Nicolene, Rossouw, H Muller, Pillay, Tahir S

“…The lipid profile is important in the risk assessment for cardiovascular disease. The lipid profile includes total cholesterol, high-density lipoprotein…”
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Industry payments to pathologists in the USA between 2013 and 2021 by Murayama, Anju, Hirota, Shuto

“…Although proper physician-industry financial relationships are essential for improving patient care, they can also cause potential conflicts of interest…”
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Expression, assessment and significance of Ki67 expression in breast cancer: an update by Lashen, Ayat Gamal, Toss, Michael S, Ghannam, Suzan Fathy, Makhlouf, Shorouk, Green, Andrew, Mongan, Nigel P, Rakha, Emad

“…Ki67 expression is one of the most important and cost-effective surrogate markers to assess for tumour cell proliferation in breast cancer (BC). The Ki67…”
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Integration of rapid PCR testing as an adjunct to NGS in diagnostic pathology services within the UK: evidence from a case series of non-squamous, non-small cell lung cancer (NSCLC) patients with follow-up by Finall, Alison, Davies, Gareth, Jones, Trevor, Emlyn, Gwion, Huey, Pearl, Mullard, Anna

“…Somatic genetic testing in non-squamous, non-small cell lung carcinoma (NSCLC) patients is required to highlight subgroups eligible for a number of novel…”
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Common variable immunodeficiency disorder (CVID)-related liver disease: assessment of the main histological aspects using novel semiquantitative scoring systems, image analysis and correlation with clinical parameters of liver stiffness and portal hypertension by Silva, Hiroshi, Brito, Camila Gabriela Xavier de, Hall, Andrew, Eden, Nadia, Somers, Henry, Burke, Niall, Burns, Siobhan O, Lowe, David, Thorburn, Douglas, Halliday, Neil, Quaglia, Alberto

“…We aimed to investigate the relationship between T-cell-mediated sinusoidal injury, nodular regenerative hyperplasia like changes (NRH-LC) and fibrosis,…”
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Mutations in ZP4 are associated with abnormal zona pellucida and female infertility by Wei, Xiaoli, Li, Youzhu, Liu, Qicai, Liu, Wensheng, Yan, Xiaohong, Zhu, Xingshen, Zhou, Dekun, Tian, Yingpu, Zhang, Fuxing, Li, Na, Lu, Zhongxian

“…The zona pellucida (ZP) of human oocytes plays essential protective roles in sperm-egg interactions during fertilisation and embryo development. -null female…”
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Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins by Tan, Puay Hoon, Thike, Aye Aye, Tan, Wai Jin, Thu, Minn Minn Myint, Busmanis, Inny, Li, Huihua, Chay, Wen Yee, Tan, Min-Han

“…To define a predictive model for clinical behaviour of breast phyllodes tumours (PT) using histological parameters and surgical margin status. Cases of breast…”
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Learning at a distance: results of an international survey on the adoption of virtual conferences and whole slide imaging by pathologists by Laohawetwanit, Thiyaphat, Gonzalez, Raul S, Bychkov, Andrey

“…This study presents the findings of a global survey of pathologists' views of online conferences and digital pathology. An online anonymous survey consisting…”
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Drug-induced hyperammonaemia by Shakerdi, Loai, Ryan, Aidan

“…Hyperammonaemia (HA) as a consequence of numerous primary or secondary causes, gives rise to clinical manifestations due to its toxic effects on the brain. The…”
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