Search Results - Anatomical Society - Wiley

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction by Palmer, Allyson K., Xu, Ming, Zhu, Yi, Pirtskhalava, Tamar, Weivoda, Megan M., Hachfeld, Christine M., Prata, Larissa G., Dijk, Theo H., Verkade, Esther, Casaclang‐Verzosa, Grace, Johnson, Kurt O., Cubro, Hajrunisa, Doornebal, Ewald J., Ogrodnik, Mikolaj, Jurk, Diana, Jensen, Michael D., Chini, Eduardo N., Miller, Jordan D., Matveyenko, Aleksey, Stout, Michael B., Schafer, Marissa J., White, Thomas A., Hickson, LaTonya J., Demaria, Marco, Garovic, Vesna, Grande, Joseph, Arriaga, Edgar A., Kuipers, Folkert, Zglinicki, Thomas, LeBrasseur, Nathan K., Campisi, Judith, Tchkonia, Tamar, Kirkland, James L.

“…Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin resistance and diabetes, but mechanisms underlying this relationship…”
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Lifelong cytomegalovirus and early-LIFE irradiation synergistically potentiate age-related defects in response to vaccination and infection by Pugh, Jason L., Coplen, Christopher P., Sukhina, Alona S., Uhrlaub, Jennifer L., Padilla‐Torres, Jose, Hayashi, Tomonori, Nikolich‐Žugich, Janko

“…Not provided…”
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Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence by Wiley, Christopher D., Flynn, James M., Morrissey, Christapher, Lebofsky, Ronald, Shuga, Joe, Dong, Xiao, Unger, Marc A., Vijg, Jan, Melov, Simon, Campisi, Judith

“…Summary Senescent cells play important roles in both physiological and pathological processes, including cancer and aging. In all cases, however, senescent…”
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Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression by Xu, Qixia, Long, Qilai, Zhu, Dexiang, Fu, Da, Zhang, Boyi, Han, Liu, Qian, Min, Guo, Jianming, Xu, Jianmin, Cao, Liu, Chin, Y. Eugene, Coppé, Jean‐Philippe, Lam, Eric W.‐F., Campisi, Judith, Sun, Yu

“…Aging is characterized by a progressive loss of physiological integrity, while cancer represents one of the primary pathological factors that severely threaten…”
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Oxidation resistance 1 is a novel senolytic target by Zhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G., Tackett, Alan J., He, Yonghan, Lv, Dongwen, Laberge, Remi‐Martin, Campisi, Judith, Wang, Jianrong, Zheng, Guangrong, Zhou, Daohong

“…Summary The selective depletion of senescent cells (SCs) by small molecules, termed senolytic agents, is a promising therapeutic approach for treating…”
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Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity by He, Yonghan, Li, Wen, Lv, Dongwen, Zhang, Xin, Zhang, Xuan, Ortiz, Yuma T., Budamagunta, Vivekananda, Campisi, Judith, Zheng, Guangrong, Zhou, Daohong

“…The accumulation of senescent cells (SnCs) is a causal factor of various age‐related diseases as well as some of the side effects of chemotherapy…”
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Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy by Liu, Hanxin, Xu, Qixia, Wufuer, Halidan, Li, Zi, Sun, Rong, Jiang, Zhirui, Dou, Xuefeng, Fu, Qiang, Campisi, Judith, Sun, Yu

“…Aging is a major risk factor for most chronic disorders, for which cellular senescence is one of the central hallmarks. Senescent cells develop the…”
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Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence by Mahoney, Sophia A., Venkatasubramanian, Ravinandan, Darrah, Mary A., Ludwig, Katelyn R., VanDongen, Nicholas S., Greenberg, Nathan T., Longtine, Abigail G., Hutton, David A., Brunt, Vienna E., Campisi, Judith, Melov, Simon, Seals, Douglas R., Rossman, Matthew J., Clayton, Zachary S.

“…Cellular senescence and the senescence‐associated secretory phenotype (SASP) contribute to age‐related arterial dysfunction, in part, by promoting oxidative…”
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Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin by Kim, Dong Eun, Dollé, Martijn E. T., Vermeij, Wilbert P., Gyenis, Akos, Vogel, Katharina, Hoeijmakers, Jan H. J., Wiley, Christopher D., Davalos, Albert R., Hasty, Paul, Desprez, Pierre‐Yves, Campisi, Judith

“…ERCC1 (excision repair cross complementing‐group 1) is a mammalian endonuclease that incises the damaged strand of DNA during nucleotide excision repair and…”
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High-throughput serum proteomics for the identification of protein biomarkers of mortality in older men by Orwoll, Eric S., Wiedrick, Jack, Jacobs, Jon, Baker, Erin S., Piehowski, Paul, Petyuk, Vladislav, Gao, Yuqian, Shi, Tujin, Smith, Richard D., Bauer, Douglas C., Cummings, Steven R., Nielson, Carrie M., Lapidus, Jodi

“…The biological perturbations associated with incident mortality are not well elucidated, and there are limited biomarkers for the prediction of mortality. In…”
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Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA) by Day, Nicholas J., Kelly, Shane S., Lui, Li‐Yung, Mansfield, Tyler A., Gaffrey, Matthew J., Trejo, Jesse B., Sagendorf, Tyler J., Attah, Isaac K., Moore, Ronald J., Douglas, Collin M., Newman, Anne B., Kritchevsky, Stephen B., Kramer, Philip A., Marcinek, David J., Coen, Paul M., Goodpaster, Bret H., Hepple, Russell T., Cawthon, Peggy M., Petyuk, Vladislav A., Esser, Karyn A., Qian, Wei‐Jun, Cummings, Steven R.

“…Oxidative stress is considered a contributor to declining muscle function and mobility during aging; however, the underlying molecular mechanisms remain poorly…”
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Age‐associated expression of p21and p53 during human wound healing by Chia, Chee W., Sherman‐Baust, Cheryl A., Larson, Sara A., Pandey, Ritu, Withers, Roxanne, Karikkineth, Ajoy C., Zukley, Linda M., Campisi, Judith, Egan, Josephine M., Sen, Ranjan, Ferrucci, Luigi

“…In mice, cellular senescence and senescence‐associated secretory phenotype (SASP) positively contribute to cutaneous wound healing. In this proof‐of‐concept…”
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Early-life atomic-bomb irradiation accelerates immunological aging and elevates immune-related intracellular reactive oxygen species by Hayashi, Tomonori, Kato, Naohiro, Furudoi, Keiko, Hayashi, Ikue, Kyoizumi, Seishi, Yoshida, Kengo, Kusunoki, Yoichiro, Furukawa, Kyoji, Imaizumi, Misa, Hida, Ayumi, Tanabe, Osamu, Ohishi, Waka

“…Reactive oxygen species (ROS) play an important role in immune responses; however, their excessive production and accumulation increases the risk of…”
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Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions by Dong, Xiao, Sun, Shixiang, Zhang, Lei, Kim, Seungsoo, Tu, Zhidong, Montagna, Cristina, Maslov, Alexander Y., Suh, Yousin, Wang, Tao, Campisi, Judith, Vijg, Jan

“…Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening…”
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Proteomic assessment of serum biomarkers of longevity in older men by Orwoll, Eric S., Wiedrick, Jack, Nielson, Carrie M., Jacobs, Jon, Baker, Erin S., Piehowski, Paul, Petyuk, Vladislav, Gao, Yuqian, Shi, Tujin, Smith, Richard D., Bauer, Douglas C., Cummings, Steven R., Lapidus, Jodi

“…The biological bases of longevity are not well understood, and there are limited biomarkers for the prediction of long life. We used a high‐throughput,…”
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FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase by Voisin, Jessica, Farina, Francesca, Naphade, Swati, Fontaine, Morgane, Tshilenge, Kizito‐Tshitoko, Galicia Aguirre, Carlos, Lopez‐Ramirez, Alejandro, Dancourt, Julia, Ginisty, Aurélie, Sasidharan Nair, Satish, Lakshika Madushani, Kuruwitage, Zhang, Ningzhe, Lejeune, François‐Xavier, Verny, Marc, Campisi, Judith, Ellerby, Lisa M., Neri, Christian

“…Neurodegenerative diseases (ND) have been linked to the critical process in aging—cellular senescence. However, the temporal dynamics of cellular senescence in…”
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Senescence chips for ultrahigh‐throughput isolation and removal of senescent cells by Chen, Yuchao, Mao, Pan, Snijders, Antoine M., Wang, Daojing

“…Summary Cellular senescence plays an important role in organismal aging and age‐related diseases. However, it is challenging to isolate low numbers of…”
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Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration by Patil, Prashanti, Dong, Qing, Wang, Dong, Chang, Jianhui, Wiley, Christopher, Demaria, Marco, Lee, Joon, Kang, James, Niedernhofer, Laura J., Robbins, Paul D., Sowa, Gwendolyn, Campisi, Judith, Zhou, Daohong, Vo, Nam

“…Rationale Age‐related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment…”
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Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging by Davis, Hannah M., Pacheco‐Costa, Rafael, Atkinson, Emily G., Brun, Lucas R., Gortazar, Arancha R., Harris, Julia, Hiasa, Masahiro, Bolarinwa, Surajudeen A., Yoneda, Toshiyuki, Ivan, Mircea, Bruzzaniti, Angela, Bellido, Teresita, Plotkin, Lilian I.

“…Summary Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the generation/function of bone forming and resorbing cells…”
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The acceleration of reproductive aging in Nrg1flox/flox;Cyp19‐Cre female mice by Umehara, Takashi, Kawai, Tomoko, Kawashima, Ikko, Tanaka, Katsuhiro, Okuda, Satoshi, Kitasaka, Hiroya, Richards, JoAnne S., Shimada, Masayuki

“…Summary Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed…”
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