Search Results - Alzheimer's & Dementia

[18 F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease by Xia, Chun-Fang, Arteaga, Janna, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F, Kasi, Dhanalakshmi, Lam, Chung, Liang, Qianwa, Liu, Changhui, Mocharla, Vani P, Mu, Fanrong, Sinha, Anjana, Su, Helen, Szardenings, A. Katrin, Walsh, Joseph C, Wang, Eric, Yu, Chul, Zhang, Wei, Zhao, Tieming, Kolb, Hartmuth C

“…Abstract Objective We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD)…”
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AD dementia risk in late MCI, in early MCI, and in subjective memory impairment by Jessen, Frank, Wolfsgruber, Steffen, Wiese, Birgitt, Bickel, Horst, Mösch, Edelgard, Kaduszkiewicz, Hanna, Pentzek, Michael, Riedel-Heller, Steffi G, Luck, Tobias, Fuchs, Angela, Weyerer, Siegfried, Werle, Jochen, van den Bussche, Hendrik, Scherer, Martin, Maier, Wolfgang, Wagner, Michael

“…Abstract Objective To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and…”
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The prevalence of dementia in urban and rural areas of China by Jia, Jianping, Wang, Fen, Wei, Cuibai, Zhou, Aihong, Jia, Xiangfei, Li, Fang, Tang, Muni, Chu, Lan, Zhou, Youlong, Zhou, Chunkui, Cui, Yong, Wang, Qi, Wang, Weishan, Yin, Peng, Hu, Nan, Zuo, Xiumei, Song, Haiqing, Qin, Wei, Wu, Liyong, Li, Dan, Jia, Longfei, Song, Juexian, Han, Ying, Xing, Yi, Yang, Peijie, Li, Yuemei, Qiao, Yuchen, Tang, Yi, Lv, Jihui, Dong, Xiumin

“…Abstract Objective The Chinese population has been aging rapidly and the country's economy has experienced exponential growth during the past three decades…”
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The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress by Kivipelto, Miia, Solomon, Alina, Ahtiluoto, Satu, Ngandu, Tiia, Lehtisalo, Jenni, Antikainen, Riitta, Bäckman, Lars, Hänninen, Tuomo, Jula, Antti, Laatikainen, Tiina, Lindström, Jaana, Mangialasche, Francesca, Nissinen, Aulikki, Paajanen, Teemu, Pajala, Satu, Peltonen, Markku, Rauramaa, Rainer, Stigsdotter-Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka

“…Abstract Background Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled…”
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The future of blood-based biomarkers for Alzheimer's disease by Henriksen, Kim, O’Bryant, Sid E, Hampel, Harald, Trojanowski, John Q, Montine, Thomas J, Jeromin, Andreas, Blennow, Kaj, Lönneborg, Anders, Wyss-Coray, Tony, Soares, Holly, Bazenet, Chantal, Sjögren, Magnus, Hu, William, Lovestone, Simon, Karsdal, Morten A, Weiner, Michael W

“…Abstract Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and…”
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Midlife risk score for the prediction of dementia four decades later by Exalto, Lieza G, Quesenberry, Charles P, Barnes, Deborah, Kivipelto, Miia, Biessels, Geert Jan, Whitmer, Rachel A

“…Abstract Objective The objective of this study was to obtain external validation of the only available midlife dementia risk score cardiovascular risk factors…”
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A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease by Rafii, Michael S, Baumann, Tiffany L, Bakay, Roy A.E, Ostrove, Jeffrey M, Siffert, Joao, Fleisher, Adam S, Herzog, Christopher D, Barba, David, Pay, Mary, Salmon, David P, Chu, Yaping, Kordower, Jeffrey H, Bishop, Kathie, Keator, David, Potkin, Steven, Bartus, Raymond T

“…Abstract Background Nerve growth factor (NGF) is an endogenous neurotrophic-factor protein with the potential to restore function and to protect degenerating…”
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Association of diabetes with amnestic and nonamnestic mild cognitive impairment by Roberts, Rosebud O, Knopman, David S, Geda, Yonas E, Cha, Ruth H, Pankratz, V. Shane, Baertlein, Luke, Boeve, Bradley F, Tangalos, Eric G, Ivnik, Robert J, Mielke, Michelle M, Petersen, Ronald C

“…Abstract Background Type 2 diabetes may increase the risk of amnestic mild cognitive impairment (aMCI) through Alzheimer's disease (AD)-related and vascular…”
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Developing novel blood-based biomarkers for Alzheimer's disease by Snyder, Heather M, Carrillo, Maria C, Grodstein, Francine, Henriksen, Kim, Jeromin, Andreas, Lovestone, Simon, Mielke, Michelle M, O'Bryant, Sid, Sarasa, Manual, Sjøgren, Magnus, Soares, Holly, Teeling, Jessica, Trushina, Eugenia, Ward, Malcolm, West, Tim, Bain, Lisa J, Shineman, Diana W, Weiner, Michael, Fillit, Howard M

“…Abstract Alzheimer's disease is the public health crisis of the 21st century. There is a clear need for a widely available, inexpensive and reliable method to…”
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Genome-wide association study of the rate of cognitive decline in Alzheimer's disease by Sherva, Richard, Tripodis, Yorghos, Bennett, David A, Chibnik, Lori B, Crane, Paul K, de Jager, Philip L, Farrer, Lindsay A, Saykin, Andrew J, Shulman, Joshua M, Naj, Adam, Green, Robert C

“…Abstract Background Substantial interindividual variability exists in the disease trajectories of Alzheimer's disease (AD) patients. Some decline rapidly…”
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Gray matter atrophy pattern in elderly with subjective memory impairment by Peter, Jessica, Scheef, Lukas, Abdulkadir, Ahmed, Boecker, Henning, Heneka, Michael, Wagner, Michael, Koppara, Alexander, Klöppel, Stefan, Jessen, Frank

“…Abstract Background Individuals with subjective memory impairment (SMI) report worsening of memory without impairment in cognitive tests. Despite normal…”
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Unobtrusive measurement of daily computer use to detect mild cognitive impairment by Kaye, Jeffrey, Mattek, Nora, Dodge, Hiroko H, Campbell, Ian, Hayes, Tamara, Austin, Daniel, Hatt, William, Wild, Katherine, Jimison, Holly, Pavel, Michael

“…Abstract Background Mild disturbances of higher order activities of daily living are present in people diagnosed with mild cognitive impairment (MCI). These…”
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Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease by Rembach, Alan, Faux, Noel G, Watt, Andrew D, Pertile, Kelly K, Rumble, Rebecca L, Trounson, Brett O, Fowler, Christopher J, Roberts, Blaine R, Perez, Keyla A, Li, Qiao-Xin, Laws, Simon M, Taddei, Kevin, Rainey-Smith, Stephanie, Robertson, Joanne S, Vandijck, Manu, Vanderstichele, Hugo, Barnham, Kevin J, Ellis, Kathryn A, Szoeke, Cassandra, Macaulay, Lance, Rowe, Christopher C, Villemagne, Victor L, Ames, David, Martins, Ralph N, Bush, Ashley I, Masters, Colin L

“…Abstract Background A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer's disease (AD). Methods Plasma amyloid beta (Aβ)1–40…”
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Biological heterogeneity in ADNI amnestic mild cognitive impairment by Nettiksimmons, Jasmine, DeCarli, Charles, Landau, Susan, Beckett, Laurel

“…Abstract Background Previous work examining normal controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) identified substantial biological…”
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Subjective cognitive decline: Self and informant comparisons by Caselli, Richard J, Chen, Kewei, Locke, Dona E.C, Lee, Wendy, Roontiva, Auttawut, Bandy, Dan, Fleisher, Adam S, Reiman, Eric M

“…Abstract Background It is unclear whether self- or informant-based subjective cognition better distinguishes emotional factors from early-stage Alzheimer's…”
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Glutathione relates to neuropsychological functioning in mild cognitive impairment by Duffy, Shantel L, Lagopoulos, Jim, Hickie, Ian B, Diamond, Keri, Graeber, Manuel B, Lewis, Simon J.G, Naismith, Sharon L

“…Abstract Background Mild cognitive impairment (MCI) represents an at-risk state for Alzheimer's disease in which underlying pathophysiological mechanisms could…”
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Results of a follow-up study to the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) by Anon., Anon

“…Abstract Objectives The Alzheimer's Disease Anti-inflammatory Prevention Trial Follow-up Study (ADAPT-FS) was designed to evaluate the efficacy of naproxen and…”
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Risk factors for mild cognitive impairment among Mexican Americans by O'Bryant, Sid E, Johnson, Leigh, Reisch, Joan, Edwards, Melissa, Hall, James, Barber, Robert, Devous, Michael D, Royall, Donald, Singh, Meharvan

“…Abstract Background Although a great deal of literature has focused on risk factors for mild cognitive impairment (MCI), little published work examines risk…”
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The cis -regulatory effect of an Alzheimer’s disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes by Linnertz, Colton, Anderson, Lauren, Gottschalk, William, Crenshaw, Donna, Lutz, Michael W, Allen, Jawara, Saith, Sunita, Mihovilovic, Mirta, Burke, James R, Welsh-Bohmer, Kathleen A, Roses, Allen D, Chiba-Falek, Ornit

“…Abstract Background We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD ( TOMM40 ) and Apolipoprotein E (…”
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Long-term associations between cholinesterase inhibitors and memantine use and health outcomes among patients with Alzheimer's disease by Zhu, Carolyn W, Livote, Elayne E, Scarmeas, Nikolaos, Albert, Marilyn, Brandt, Jason, Blacker, Deborah, Sano, Mary, Stern, Yaakov

“…Abstract Objectives To examine in an observational study (1) relationships between cholinesterase inhibitors (ChEI) and memantine use, and functional and…”
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