Search Results - "woo, Juhyung"

ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis by Chung, Seung J., Nagaraju, Ganji Purnachandra, Nagalingam, Arumugam, Muniraj, Nethaji, Kuppusamy, Panjamurthy, Walker, Alyssa, Woo, Juhyung, Győrffy, Balázs, Gabrielson, Ed, Saxena, Neeraj K., Sharma, Dipali

“…ADIPOQ/adiponectin, an adipocytokine secreted by adipocytes in the breast tumor microenvironment, negatively regulates cancer cell growth hence increased…”
Get full text

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors by Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H, Zhang, Ya-Qin, Rohde, Jason M, Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R, Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A, Xia, Menghang, Woo, Juhyung, Mensah, George A, Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B, Biswal, Shyam

“…Loss of function mutations in Kelch-like ECH Associated Protein 1 (KEAP1), or gain-of-function mutations in nuclear factor erythroid 2-related factor 2 (NRF2),…”
Get full text

An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss by Asrani, Kaushal, Woo, Juhyung, Mendes, Adrianna A., Schaffer, Ethan, Vidotto, Thiago, Villanueva, Clarence Rachel, Feng, Kewen, Oliveira, Lia, Murali, Sanjana, Liu, Hans B., Salles, Daniela C., Lam, Brandon, Argani, Pedram, Lotan, Tamara L.

“…The mechanistic target of rapamycin complex 1 (mTORC1) integrates inputs from growth factors and nutrients, but how mTORC1 autoregulates its activity remains…”
Get full text

Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer by Asrani, Kaushal, Torres, Alba FC, Woo, Juhyung, Vidotto, Thiago, Tsai, Harrison K, Luo, Jun, Corey, Eva, Hanratty, Brian, Coleman, Ilsa, Yegnasubramanian, Srinivasan, De Marzo, Angelo M, Nelson, Peter S, Haffner, Michael C, Lotan, Tamara L

“…Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy…”
Get full text

AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer by Jhaveri, Teraneh Z, Woo, Juhyung, Shang, Xiaobin, Park, Ben Ho, Gabrielson, Edward

“…AMP-activated Protein Kinase (AMPK) activity retards growth of many types of cancers. Investigating effects of AMPK activation on breast cancer cell signaling…”
Get full text

Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment by Muniraj, Nethaji, Siddharth, Sumit, Shriver, Marey, Nagalingam, Arumugam, Parida, Sheetal, Woo, Juhyung, Elsey, Justin, Gabrielson, Kathleen, Gabrielson, Edward, Arbiser, Jack L., Saxena, Neeraj K., Sharma, Dipali

“…Cancer cells hijack autophagy pathway to evade anti-cancer therapeutics. Many molecular signaling pathways associated with drug-resistance converge on…”
Get full text

Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells by Tully, Ellen, Bharti, Santosh, Woo, Juhyung, Bhujwalla, Zaver, Gabrielson, Edward

“…Biguanide drugs (metformin and phenformin) have drawn interest for potential cancer treatments, and laboratory studies show that some cancer cells are…”
Get full text

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation by Walker, Alyssa, Singh, Anju, Tully, Ellen, Woo, Juhyung, Le, Anne, Nguyen, Tu, Biswal, Shyam, Sharma, Dipali, Gabrielson, Edward

“…Autophagy can serve as a mechanism for survival of cells during nutrient deprivation by recycling cellular macromolecules and organelles transiently to provide…”
Get full text

GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms by Salles, Daniela C, Asrani, Kaushal, Woo, Juhyung, Vidotto, Thiago, Liu, Hans B, Vidal, Igor, Matoso, Andres, Netto, George J, Argani, Pedram, Lotan, Tamara L

“…GPNMB (glycoprotein nonmetastatic B) and other TFE3/TFEB transcriptional targets have been proposed as markers for microphthalmia (MiT) translocation renal…”
Get full text

Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells by Muniraj, Nethaji, Siddharth, Sumit, Nagalingam, Arumugam, Walker, Alyssa, Woo, Juhyung, Győrffy, Balázs, Gabrielson, Ed, Saxena, Neeraj K, Sharma, Dipali

“…Withaferin A (WFA), a steroidal lactone, negatively regulates breast cancer growth however, its mechanisms of action remain largely elusive. We found that WFA…”
Get full text

Abstract 2431: mTORC1 paradoxically drives MiT/TFE activity and lysosomal biogenesis in tuberous sclerosis complex by Asrani, Kaushal V., Salles, Daniela, Woo, Juhyung, Mendes, Adrianna, Murali, Sanjana, Vidotto, Thiago, Argani, Pedram, Gabrielson, Edward, Lotan, Tamara

“…Abstract Background: Tuberous Sclerosis Complex (TSC) is characterized by TSC1/2 loss, dysregulated mTORC1 signaling & renal tumors (angiomyolipomas (AML) &…”
Get full text

Prognostic Impact of Phosphorylated Discoidin Domain Receptor-1 in Esophageal Cancer by Sugimoto, Kiichi, Ito, Tomoaki, Woo, Juhyung, Tully, Ellen, Sato, Koichi, Orita, Hajime, Brock, Malcolm V., Gabrielson, Edward

“…Esophageal squamous cell carcinoma (ESCC) is common in East Asia and also is often deadly. We sought to determine whether measuring the discoidin domain…”
Get full text

Abstract A019: Development and characterization of novel pre-clinical models of SFPQ-TFE3-driven renal cell carcinoma by de Aragao Mendes, Adrianna Amaral, Liu, Hans, Woo, Juhyung, Asrani, Kaushal, Rosenberg, Avi, Argani, Pedram, Lotan, Tamara

“…Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR001) of…”
Get full text

Abstract PR001: Development and characterization of novel pre-clinical models of SFPQ-TFE3-driven renal cell carcinoma by de Aragao Mendes, Adrianna Amaral, Liu, Hans, Woo, Juhyung, Asrani, Kaushal, Rosenberg, Avi, Argani, Pedram, Lotan, Tamara

“…Abstract Translocation Renal Cell Carcinomas (tRCC) are characterized by gene fusions that drive expression of chimeric TFE3 (Xp11.2) or TFEB (6p21.2). We…”
Get full text

Abstract 5928: Discoidin domain receptor-1 (DDR1) is an independent prognostic marker of poor prognosis in esophageal squamous cell carcinoma by Sugimoto, Kiichi, Ito, Tomoaki, Orita, Hajime, Sato, Koichi, Sakamoto, Kazuhiro, Sakurada, Mutsumi, Kushida, Tomoyuki, Maekawa, Hiroshi, Tully, Ellen, Woo, Juhyung, Gabrielson, Edward

“…Abstract Introduction: Esophageal squamous cell carcinoma (ESCC), which is the most common type of esophageal cancer, is one of the most common cancers in…”
Get full text

Abstract 3319: Elevating adipokine adiponectin level can induce cytotoxic autophagy in breast cancer cells and potentiate the efficacy of chemotherapeutic regimens: preclinical studies by Chung, Seung J, Nagaraju, Ganji Purnachandra, Nagalingam, Arumugam, Muniraj, Nethaji, Kuppusamy, Panjamurthy, Walker, Alyssa, woo, Juhyung, Győrffy, Balázs, Gabrielson, Edward, Saxena, Neeraj K., Sharma, Dipali

“…Abstract Adiponectin, an adipocytokine secreted by adipocytes in the breast tumor microenvironment, negatively regulates cancer cell growth hence increased…”
Get full text