Search Results - "von Zezschwitz, Paultheo"

Improved Synthesis of Cyclic Tertiary Allylic Alcohols by Asymmetric 1,2-Addition of AlMe3 to Enones by Kolb, Andreas, Zuo, Wei, Siewert, Jürgen, Harms, Klaus, von Zezschwitz, Paultheo

“…The development of an improved protocol for the enantioselective RhI/binap‐catalysed 1,2‐addition of AlMe3 to cyclic enones is reported. 31P NMR analysis of…”
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Kinetic Resolution of Chiral Cyclohex-2-enones by Rhodium(I)/binap-Catalyzed 1,2- and 1,4-Additions by Kolb, Andreas, Hirner, Sebastian, Harms, Klaus, Zezschwitz, Paultheo von

“…The feasibility of kinetic resolutions of racemic monosubstituted cyclohex-2-enones by Rh/binap-catalyzed reactions was investigated. 1,2-Addition of AlMe3 to…”
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First Tandem Asymmetric Conjugate Addition of Alkenyl Nucleophiles and Silyl Trapping of the Intermediate Enolates by Westmeier, Johannes, Pfaff, Christopher, Siewert, Jürgen, von Zezschwitz, Paultheo

“…The tandem asymmetric conjugate addition of alkyl or aryl groups to enones and subsequent silyl trapping has already been achieved and yields valuable silyl…”
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Rhodium-Catalyzed Enantioselective 1,2-Addition of Aluminum Organyl Compounds to Cyclic Enones by Siewert, Jürgen, Sandmann, René, von Zezschwitz, Paultheo

“…A question of the ligand: The chemoselectivity of the rhodium‐catalyzed addition of AlMe3 to cyclohex‐2‐enone is guided by the type of ligand used. Whereas use…”
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Spirodionic Acid, a Novel Metabolite from Streptomyces sp., Part 2: Total Synthesis through a Twofold Michael Addition as a Selective Spiroannelation Strategy by Siewert, Jürgen, Textor, Adriana, Grond, Stephanie, von Zezschwitz, Paultheo

“…To elucidate the structure of the new natural product spirodionic acid, which has three stereogenic centers of hitherto unknown configuration, two…”
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The Virtue of Palladium-Catalyzed Domino Reactions − Diverse Oligocyclizations of Acyclic 2-Bromoenynes and 2-Bromoenediynes by de Meijere, Armin, von Zezschwitz, Paultheo, Bräse, Stefan

“…The domino-type combination of consecutive palladium-catalyzed cross-coupling reactions with subsequent pericyclic transformations offers a very fast access to…”
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Rhodium-Catalyzed Enantioselective Addition of Organoaluminum Reagents to N‑Tosyl Ketimines by Hirner, Sebastian, Kolb, Andreas, Westmeier, Johannes, Gebhardt, Sandra, Middel, Stephen, Harms, Klaus, von Zezschwitz, Paultheo

“…Rhodium(I)/Binap complexes catalyze highly enantioselective additions of methyl- and arylaluminum reagents to cyclic α,β-unsaturated N-tosyl ketimines…”
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Enantioselective Preparation of 3-Arylcycloalkylamines by Rhodium-Catalyzed 1,4-Addition and Subsequent Stereodivergent Reduction by Gebhardt, Sandra, Müller, Christian H., Westmeier, Johannes, Harms, Klaus, von Zezschwitz, Paultheo

“…N‐Sulfonylimines of cycloalk‐2‐enones are well‐suited for the enantioselective rhodium(I)/binap‐catalyzed 1,4‐additions of arylzinc halides. The cyclic…”
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Archazolid A Binds to the Equatorial Region of the c-Ring of the Vacuolar H+-ATPase by Bockelmann, Svenja, Menche, Dirk, Rudolph, Sven, Bender, Tobias, Grond, Stephanie, von Zezschwitz, Paultheo, Muench, Stephen P., Wieczorek, Helmut, Huss, Markus

“…The macrolactone archazolid is a novel, highly specific V-ATPase inhibitor with an IC50 value in the low nanomolar range. The binding site of archazolid is…”
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Enantioselective Synthesis of 3,4-Disubstituted cis- and trans-1,2,5-Thiadiazolidine-1,1-dioxides as Precursors for Chiral 1,2-Diamines by Schüttler, Christian, Li-Böhmer, Zhen, Harms, Klaus, von Zezschwitz, Paultheo

“…Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared…”
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The Binding Site of the V-ATPase Inhibitor Apicularen Is in the Vicinity of Those for Bafilomycin and Archazolid by Osteresch, Christin, Bender, Tobias, Grond, Stephanie, von Zezschwitz, Paultheo, Kunze, Brigitte, Jansen, Rolf, Huss, Markus, Wieczorek, Helmut

“…The investigation of V-ATPases as potential therapeutic drug targets and hence of their specific inhibitors is a promising approach in osteoporosis and cancer…”
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Iromycins:  A New Family of Pyridone Metabolites from Streptomyces sp. II. Convergent Total Synthesis by Shojaei, Heydar, Li-Böhmer, Zhen, von Zezschwitz, Paultheo

“…The total synthesis of iromycin A (1a), a microbial metabolite combining a novel structure with an interesting biological activity as a NO synthase inhibitor,…”
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The New Metabolite (S)-Cinnamoylphosphoramide from Streptomyces sp. and Its Total Synthesis by Quitschau, Melanie, Schuhmann, Tim, Piel, Jörn, von Zezschwitz, Paultheo, Grond, Stephanie

“…The tunicate‐associated strain Streptomyces sp. JP90 produces the unprecedented metabolite cinnamoylphosphoramide (1) among several other compounds. Structure…”
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Convenient Synthesis of a [1-14C]Diazirinylbenzoic Acid as a Photoaffinity Label for Binding Studies of V-ATPase Inhibitors by Bender, Tobias, Huss, Markus, Wieczorek, Helmut, Grond, Stephanie, von Zezschwitz, Paultheo

“…Diazirine‐tagged systems are considered reliable compounds for photoaffinity labeling (PAL) in biochemical studies as they enable investigation and…”
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Spirodionic Acid, a Novel Metabolite from Streptomyces sp., Part 1: Structure Elucidation and Diels-Alder-Type Biosynthesis by Textor, Adriana, Papastavrou, Ina, Siewert, Jürgen, Magull, Jörg, Kulik, Andreas, Fiedler, Hans-Peter, von Zezschwitz, Paultheo, Grond, Stephanie

“…Spirodionic acid (1), a novel microbial metabolite with a spiro[4.5]decene skeleton, the 6‐ethyl‐2H‐pyrone 5, dihydrosarkomycin (6), and other metabolites were…”
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A New Phototransformation of Methoxycarbonyl-Substituted (E,Z,E)-1,3,5-Hexatrienes: Easy Access to Ring-Annelated 8-Oxabicyclo[3.2.1]octa-2,6-diene Derivatives by von Essen, Regina, von Zezschwitz, Paultheo, Vidović, Denis, de Meijere, Armin

“…On attempting photochemically induced electrocyclizations of the previously reported 1,6‐bismethoxycarbonyl‐ or 1,6‐bistrimethylsilyl‐substituted ring‐attached…”
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Versatile Synthesis of 11-Oxabicyclo[4.4.1]undeca-1,5-dienes by Selective Epoxidation of 1,6-Disubstituted (E,Z , E)-1,3,5-Hexatrienes and Subsequent Cope Rearrangement by von Zezschwitz, Paultheo, Voigt, Katharina, Lansky, Annegret, Noltemeyer, Mathias, de Meijere, Armin

“…1,6-Disubstituted (E,Z,E)-1,3,5-hexatrienes (1a − c, 2a − e), obtained in good yields (43−81%) by 2-fold Heck couplings of 1,2-dibromocyclopentene and…”
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Total Synthesis of (R)‑Sarkomycin via Asymmetric Rhodium-Catalyzed Conjugate Addition by Westmeier, Johannes, Kress, Steffen, Pfaff, Christopher, von Zezschwitz, Paultheo

“…(R)-Sarkomycin was prepared using a five-step total synthesis. Key steps in the enantioselective construction of the targeted scaffold were a rhodium-catalyzed…”
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Rhodiumkatalysierte enantioselektive 1,2‐Addition von Organoaluminiumverbindungen an cyclische Enone by Siewert, Jürgen, Sandmann, René, von Zezschwitz, Paultheo

“…Eine Frage des Liganden: Die Chemoselektivität der rhodiumkatalysierten Addition von AlMe3 an Cyclohex‐2‐enon wird durch die Art des Liganden gesteuert. So…”
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Improved Synthesis of Cyclic Tertiary Allylic Alcohols by Asymmetric 1,2‐Addition of AlMe 3 to Enones by Kolb, Andreas, Zuo, Wei, Siewert, Jürgen, Harms, Klaus, von Zezschwitz, Paultheo

“…The development of an improved protocol for the enantioselective Rh I /binap‐catalysed 1,2‐addition of AlMe 3 to cyclic enones is reported. 31 P NMR analysis…”
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