Search Results - "von Witzleben, Adrian"

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy by von Witzleben, Adrian, Wang, Chuan, Laban, Simon, Savelyeva, Natalia, Ottensmeier, Christian H

“…Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of malignant tumours typically caused by alcohol and tobacco consumption, although an…”
Get full text

Immune checkpoint expression in HNSCC patients before and after definitive chemoradiotherapy by Doescher, Johannes, Minkenberg, Peter, Laban, Simon, Kostezka, Ulrike, Witzleben, Adrian, Hoffmann, Thomas Karl, Schuler, Patrick Johannes, Weissinger, Stephanie Ellen

“…Background Primary platinum‐based chemoradiotherapy (CRT) remains the treatment of choice for nonresectable squamous cell carcinoma of the head and neck…”
Get full text

Prospective longitudinal study of immune checkpoint molecule (ICM) expression in immune cell subsets during curative conventional therapy of head and neck squamous cell carcinoma (HNSCC) by Witzleben, Adrian, Fehn, Adrian, Grages, Ayla, Ezić, Jasmin, Jeske, Sandra S., Puntigam, Lisa K., Brunner, Cornelia, Kraus, Johann M., Kestler, Hans A., Doescher, Johannes, Brand, Matthias, Theodoraki, Marie‐Nicole, Ottensmeier, Christian H., Hoffmann, Thomas K., Schuler, Patrick J., Laban, Simon

“…Programmed‐death‐1 (PD1) antibodies are approved for recurrent and metastatic head and neck squamous cell carcinoma. Multiple drugs targeting costimulatory and…”
Get full text

JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells by Eschweiler, Simon, Wang, Alice, Ramírez-Suástegui, Ciro, von Witzleben, Adrian, Li, Yingcong, Chee, Serena J., Simon, Hayley, Mondal, Monalisa, Ellis, Matthew, Thomas, Gareth J., Chandra, Vivek, Ottensmeier, Christian H., Vijayanand, Pandurangan

“…Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer…”
Get full text

Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions by von Witzleben, Adrian, Müller-Richter, Urs, Maurus, Katja, Brändlein, Stephanie, Theodoraki, Marie-Nicole, Brunner, Cornelia, Laban, Simon, Lennerz, Jochen, Möller, Peter, Hoffmann, Thomas K, Doescher, Johannes, Schuler, Patrick J

“…Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers and patients have limited therapy options if primary treatment fails…”
Get full text

Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma by Mytilineos, Daphne, Ezić, Jasmin, von Witzleben, Adrian, Mytilineos, Joannis, Lotfi, Ramin, Fürst, Daniel, Tsamadou, Chrysanthi, Theodoraki, Marie-Nicole, Oster, Angelika, Völkel, Gunnar, Kestler, Hans A, Brunner, Cornelia, Schuler, Patrick J, Doescher, Johannes, Hoffmann, Thomas K, Laban, Simon

“…Cytokines and immune mediators play an important role in the communication between immune cells guiding their response to infectious diseases or cancer. In…”
Get full text

Increasing Mean Age of Head and Neck Cancer Patients at a German Tertiary Referral Center by Vahl, Julius M, Wigand, Marlene C, Denkinger, Michael, Dallmeier, Dhayana, Steiger, Chiara, Welke, Claudia, Kuhn, Peter, Idel, Christian, Doescher, Johannes, von Witzleben, Adrian, Brand, Matthias, Marienfeld, Ralf, Möller, Peter, Theodoraki, Marie-Nicole, Greve, Jens, Schuler, Patrick J, Brunner, Cornelia, Hoffmann, Thomas K, Laban, Simon

“…The impact of demographic change on the age at diagnosis in German head and neck cancer (HNC) patients is unclear. Here we present an evaluation of aging…”
Get full text

Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens by Abou Kors, Tsima, Meier, Matthias, Mühlenbruch, Lena, Betzler, Annika C, Oliveri, Franziska, Bens, Martin, Thomas, Jaya, Kraus, Johann M, Doescher, Johannes, von Witzleben, Adrian, Hofmann, Linda, Ezic, Jasmin, Huber, Diana, Benckendorff, Julian, Barth, Thomas F E, Greve, Jens, Schuler, Patrick J, Brunner, Cornelia, Blackburn, Jonathan M, Hoffmann, Thomas K, Ottensmeier, Christian, Kestler, Hans A, Rammensee, Hans-Georg, Walz, Juliane S, Laban, Simon

“…The human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T…”
Get full text

HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas by Jäger, Daniela, Barth, Thomas F. E., Brüderlein, Silke, Scheuerle, Angelika, Rinner, Beate, von Witzleben, Adrian, Lechel, André, Meyer, Patrick, Mayer-Steinacker, Regine, Baer, Alexandra von, Schultheiss, Markus, Wirtz, Christian R., Möller, Peter, Mellert, Kevin

“…Chordomas are rare tumours of the bone arising along the spine from clivus to sacrum. We compared three chordoma cell lines of the clivus region including the…”
Get full text

Changes in Gene Expression Patterns in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Under Chemoradiotherapy Depend on Response by Doescher, Johannes, von Witzleben, Adrian, Boukas, Konstantinos, Weissinger, Stephanie E, Thomas, Gareth J, Laban, Simon, Thomas, Jaya, Hoffmann, Thomas K, Ottensmeier, Christian H

“…Chemoradiotherapy (CRT) is a standard treatment for advanced head and neck squamous cell carcinoma (HNSCC). Unfortunately, not all patients respond to this…”
Get full text

Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer by McCann, Katy, von Witzleben, Adrian, Thomas, Jaya, Wang, Chuan, Wood, Oliver, Singh, Divya, Boukas, Konstantinos, Bendjama, Kaidre, Silvestre, Nathalie, Nielsen, Finn Cilius, Thomas, Gareth, Sanchez-Elsner, Tilman, Greenbaum, Jason, Schoenberger, Stephen, Peters, Bjoern, Vijayanand, Pandurangan, Savelyeva, Natalia, Ottensmeier, Christian

“…BackgroundCancer is characterized by an accumulation of somatic mutations, of which a significant subset can generate cancer-specific neoepitopes that are…”
Get full text

Demographics and access to head and neck cancer care in rural areas compared to urban areas in Germany by Vahl, Julius M., Nagel, Gabriele, Grages, Ayla, Brand, Matthias, Witzleben, Adrian, Sonntag, Michael, Theodoraki, Marie‐Nicole, Greve, Jens, Aboukors, Tsima, Denkinger, Michael, Dallmeier, Dhayana, Idel, Christian, Hoffmann, Thomas K., Laban, Simon

“…Background Demographic development in rural and urban areas differs substantially. Demographics and access to specialized head and neck cancer centers may…”
Get full text

Regional outcome disparities in German head and neck cancer patients: Shorter survival in Eastern Germany by Vahl, Julius M., Nagel, Gabriele, Abou Kors, Tsima, Brand, Matthias, Witzleben, Adrian, Sonntag, Michael, Grages, Ayla, Theodoraki, Marie N., Greve, Jens, Denkinger, Michael, Dallmeier, Dhayana, Idel, Christian, Stilgenbauer, Stephan, Hoffmann, Thomas K., Laban, Simon

“…Introduction Demographics are important prognostic factors in malignant diseases. A nationwide analysis concerning the prognostic impact of demographics in…”
Get full text

Correlation of HPV16 Gene Status and Gene Expression With Antibody Seropositivity and TIL Status in OPSCC by von Witzleben, Adrian, Currall, Eve, Wood, Oliver, Chudley, Lindsey, Akinyegun, Oluyemisi, Thomas, Jaya, Bendjama, Kaïdre, Thomas, Gareth J, Friedmann, Peter S, King, Emma V, Laban, Simon, Ottensmeier, Christian H

“…Human papillomavirus 16 (HPV16) is the main cause of oropharyngeal squamous cell carcinoma (OPSCC). To date, the links between HPV16 gene expression and…”
Get full text

Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib by Schultheiss, Markus, Rücker, Frank G., Möller, Peter, Bullinger, Lars, Barth, Thomas F. E., von Baer, Alexandra, Wittau, Mathias, Brüderlein, Silke, von Witzleben, Adrian, Mellert, Kevin, Jäger, Daniela, Marienfeld, Ralf, Böhm, Michael J., Mayer-Steinacker, Regine

“…Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we…”
Get full text

Tumor-Infiltrating CD103+ Tissue-Resident Memory T Cells and CD103-CD8+ T Cells in HNSCC Are Linked to Outcome in Primary but not Metastatic Disease by von Witzleben, Adrian, Ellis, Matthew, Thomas, Gareth J, Hoffmann, Thomas K, Jackson, Richard, Laban, Simon, Ottensmeier, Christian H

“…High numbers of tumor-infiltrating lymphocytes (TIL) are linked to better survival in patients with cancer. Tissue-resident memory T cells (TRM; CD8+CD103+)…”
Get full text

Contrast‐Enhanced Computed Tomography ( CT ) With Concordant Sonography as Sufficient Early Detection Tools for Recurrent and Persistent Cervical Metastases After (Chemo)radiotherapy ( CRT ) by Stöcker, Carl, Greve, Jens, Beer, Meinrad, Hosch, Beate, Barth, Thomas F. E., Hoffmann, Thomas K., von Witzleben, Adrian

“…ABSTRACT Background Most challenging treatment needs are in recurrent or persisting head and neck squamous cell carcinoma (HNSCC) patients after…”
Get full text

Immunotherapy for head and neck tumors : Updates from the 2024 ASCO Annual Meeting by von Witzleben, Adrian, Doescher, Johannes, Hoffmann, Thomas K, Laban, Simon

“…Immunotherapeutic approaches are now established in the treatment of various tumor entities, including head and neck squamous cell carcinoma (HNSCC). PD‑1…”
Get full text

Bending the rules: A novel approach to laryngeal surgery in a body donor study by Kienle, Linus L, Schild, Leon R, Boehm, Felix, Hahn, Viola D, Greve, Jens, von Witzleben, Adrian, Hoffmann, Thomas K, Schuler, Patrick J

“…Transoral laser microsurgery, the standard surgical approach for early-stage laryngeal cancer, necessitates an unobstructed line of sight to the operating…”
Get full text

Immunotherapy in the context of other head and neck cancer treatment modalities-highlights of the ASCO and ESMO annual meeting 2022 by von Witzleben, Adrian, Hoffmann, Thomas K, Laban, Simon

“…Immunotherapeutic agents are nowadays established for treatment of a wide variety of tumor entities, including squamous cell carcinoma of the head and neck…”
Get full text