Search Results - "von Smitten, K."

The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1 BRCA2-deficient and ER PR ERBB2-triple-negative breast cancer by Tommiska, J, Bartkova, J, Heinonen, M, Hautala, L, Kilpivaara, O, Eerola, H, Aittomäki, K, Hofstetter, B, Lukas, J, von Smitten, K, Blomqvist, C, Ristimäki, A, Heikkilä, P, Bartek, J, Nevanlinna, H

“…The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose…”
Get full text

Late results of skin-sparing mastectomy followed by immediate breast reconstruction by Meretoja, T. J., Rasia, S., von Smitten, K. A. J., Asko-Seljavaara, S. L., Kuokkanen, H. O. M., Jahkola, T. A.

“…Background: Skin‐sparing mastectomy (SSM) facilitates optimal immediate breast reconstruction (IBR) by preserving the inframammary fold and most of the breast…”
Get full text

Pain and other symptoms during the first year after radical and conservative surgery for breast cancer by TASMUTH, T, VON SMITTEN, K, KALSO, E

“…This study assessed pain, neurological symptoms, oedema of the ipsilateral arm, anxiety and depression occurring in women treated surgically for breast cancer,…”
Get full text

Skin-Sparing Mastectomy and Immediate Breast Reconstruction in the Management of Locally Recurrent Breast Cancer by Lindford, A. J., Meretoja, T. J., von Smitten, K. A. J., Jahkola, T. A.

“…Aim To investigate whether skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) is a possible treatment option in selected cases of locally…”
Get full text

Breast cancer outcome prediction with tumour tissue images and machine learning by Turkki, Riku, Byckhov, Dmitrii, Lundin, Mikael, Isola, Jorma, Nordling, Stig, Kovanen, Panu E., Verrill, Clare, von Smitten, Karl, Joensuu, Heikki, Lundin, Johan, Linder, Nina

“…Purpose Recent advances in machine learning have enabled better understanding of large and complex visual data. Here, we aim to investigate patient outcome…”
Get full text

Local recurrence of stage 1 and 2 breast cancer after skin-sparing mastectomy and immediate breast reconstruction in a 15-year series by Meretoja, T.J, von Smitten, K.A.J, Leidenius, M.H.K, Svarvar, C, Heikkilä, P.S, Jahkola, T.A

“…Abstract Aims Since the introduction of skin-sparing mastectomy (SSM) in 1991 concerns on local control and recurrence rates have been discussed in the…”
Get full text

Pain and other symptoms after different treatment modalities of breast cancer by Tasmuth, T, von Smitten, K, Hietanen, P, Kataja, M, Kalso, E

“…The aim of this study was to analyse the risk factors that predispose women to chronic symptoms related to the treatment of breast cancer. A questionnaire was…”
Get more information

Tenascin-C expression in invasion border of early breast cancer: a predictor of local and distant recurrence by JAHKOLA, T, TOIVONEN, T, VIRTANEN, I, VON SMITTEN, K, NORDLING, S, VON BOGUSLAWSKI, K, HAGLUND, C, NEVANLINNA, H, BLOMQVIST, C

“…We have recently demonstrated an association between distant metastasis and the expression of the extracellular matrix glycoprotein tenascin-C (Tn-C) in the…”
Get full text

Expression of Tenascin-C in intraductal carcinoma of human breast: relationship to invasion by Jahkola, T, Toivonen, T, Nordling, S, von Smitten, K, Virtanen, I

“…Tenascin-C (Tn-C) is an extracellular matrix glycoprotein that appears in areas of epithelial–mesenchymal interaction during fetal development and in…”
Get full text

A second radioisotope injection enhances intraoperative sentinel node identification in breast cancer patients without visualized nodes on preoperative lymphoscintigraphy by Leikola, J P, Leppänen, E A, von Smitten, K A J, Leidenius, M H K

“…To evaluate the influence of a second radioisotope injection on the intraoperative success rate in patients with non-visualized axillary sentinel nodes (SN)…”
Get more information

The consequences of long-time arm morbidity in node-negative breast cancer patients with sentinel node biopsy or axillary clearance by Leidenius, M., Leivonen, M., Vironen, J., von Smitten, K.

“…Background The aim was to evaluate long‐time morbidity in breast cancer patients 3 years after sentinel node biopsy (SNB) or axillary clearance (AC)…”
Get full text

Sentinel node biopsy with intraoperative diagnosis in patients undergoing skin-sparing mastectomy and immediate breast reconstruction by Meretoja, T.J, Jahkola, T.A, Toivonen, T.S, Krogerus, L.A, Heikkilä, P.S, von Smitten, K.A.J, Leidenius, M.H.K

“…Abstract Aims False negative cases in the intraoperative assessment of sentinel node (SN) metastases in breast cancer prompt for a secondary axillary lymph…”
Get full text

Adjusting the radioisotope tracer dose according to the body mass index does not enhance the visualization of axillary sentinel lymph nodes by Leikola, J P, Leppänen, E A, von Smitten, K A J, Leidenius, M H K

“…To investigate whether the visualization of axillary sentinel nodes (SN) in the lymphoscintigraphy (LS) can be enhanced by adjusting the amount of…”
Get more information

Towards reasonable workload in diagnosis of sentinel lymph nodes: comparison of two frozen section methods by Krogerus, L A, Leidenius, M H K, Toivonen, T S, Von Smitten, K J A

“…Aims : To compare two methods of histological assessment with intraoperative diagnosis of sentinel node metastases in breast cancer. Methods and results : A…”
Get full text

Prognostic value of Ki-67 immunolabelling in primary operable breast cancer by RAILO, M, NORDLING, S, VON BOGUSLAWSKY, K, LEIVONEN, M, KYLLÖNEN, L, VON SMITTEN, K

“…The prognostic value of Ki-67 immunohistochemical labelling was evaluated in 327 operable primary carcinomas of the breast. The follow-up time was up to 4…”
Get full text

Tumour-positive sentinel node findings in patients with ductal carcinoma in situ by Leidenius, M., Salmenkivi, K., von Smitten, K., Heikkilä, P.

“…Background Our aim was to evaluate the prevalence of and risk factors for tumour‐positive sentinel node (SN) findings in patients with ductal carcinoma in situ…”
Get full text

Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors by JAHKOLA, T, TOLVONEN, T, VON SMITTEN, K, VIRTANEN, I, WASENIUS, V.-M, BLOMQVIST, C

“…Cytosolic determinations of cathepsin-D (cath-D), urokinase plasminogen activator (uPA) and its specific inhibitor PAI-1 have shown an association with adverse…”
Get full text

One-year morbidity after sentinel node biopsy and breast surgery by Rönkä, R., von Smitten, K., Tasmuth, T., Leidenius, M.

“…Posttreatment morbidity within 1 year after sentinel node biopsy was evaluated objectively by physical examination and also by evaluating patients self-reports…”
Get full text

The role of Tc99m-sestamibi scintimammography in combination with the triple assessment of primary breast cancer by Leidenius, M.H.K., Leppänen, E.A., Tykkä, H.T., von Smitten, K.A.J.

“…Aim: The aim of this study was to evaluate if Tc99m-sestamibi scintimammography in addition to the triple assessment consisting of clinical examination,…”
Get full text

USAXS and SAXS from cancer-bearing breast tissue samples by Fernández, M, Suhonen, H, Keyriläinen, J, Bravin, A, Fiedler, S, Karjalainen-Lindsberg, M.-L, Leidenius, M, von Smitten, K, Suortti, P

“…Abstract USAXS and SAXS patterns from cancer-bearing human breast tissue samples were recorded at beamline ID02 of the ESRF using a Bonse–Hart camera and a…”
Get full text