Search Results - "von Lubitz, D K"

Adenosine and cerebral ischemia: therapeutic future or death of a brave concept? by Von Lubitz, Dag K.J.E.

“…Numerous studies have consistently shown that agonist stimulation of adenosine A 1 receptors results in a significant reduction of morbidity and mortality…”
Get full text

Adenosine and cerebral ischemia: therapeutic future or death of a brave concept? by von Lubitz, Dag K.J.E

“…Numerous studies have consistently shown that agonist stimulation of adenosine A 1 receptors results in a significant reduction of morbidity and mortality…”
Get full text

Adenosine A3 receptor stimulation and cerebral ischemia by Von Lubitz, D K, Lin, R C, Popik, P, Carter, M F, Jacobson, K A

“…Chronic treatment with the selective adenosine A3 receptor agonist N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (IB-MECA) administered prior to either 10…”
Get more information

G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain by Abbracchio, M P, Brambilla, R, Ceruti, S, Kim, H O, von Lubitz, D K, Jacobson, K A, Cattabeni, F

“…The recently cloned G protein-coupled adenosine A3 receptor has been proposed to play a role in the pathophysiology of cerebral ischemia. Because phospholipase…”
Get more information

Cerebral ischemia in gerbils : effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist by VON LUBITZ, D. K. J. E, LIN, R. C. S, JACOBSON, K. A

“…Despite significant progress in understanding of the potential of adenosine A1 receptor-based therapies in treatment of cerebral ischemia and stroke, very…”
Get full text

Adenosine receptor ligands: differences with acute versus chronic treatment by Jacobson, Kenneth A., von Lubitz, Dag K.J.E., Daly, John W., Fredholm, Bertil B.

“…Adenosine receptors have been the target of intense research with respect to potential use of selective ligands in a variety of therapeutic areas. Caffeine and…”
Get full text

Chronic administration of adenosine A3 receptor agonist and cerebral ischemia : neuronal and glial effects by VON LUBITZ, D. K. J. E, LIN, R. C.-S, BOYD, M, BISCHOFBERGER, N, JACOBSON, K. A

“…We have previously shown that chronic administration of the selective A3 receptor agonist N6-(3-iodobenzyl)-5'-N-methylcarboxoamidoadenosine (IB-MECA) leads to…”
Get full text

Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist by VON LUBITZ, D. K. J. E, LIN, R. C.-S, BISCHOFBERGER, N, BEENHAKKER, M, BOYD, M, LIPARTOWSKA, R, JACOBSON, K. A

“…Although the selectivity and potency of adenosine amine congener (ADAC) at adenosine A1 receptors are similar to other highly selective agonists at this…”
Get full text

The effects of adenosine A3 receptor stimulation on seizures in mice by VON LUBITZ, D. K. J. E, CARTER, M. F, DEUTSCH, S. I, LIN, R. C.-S, MASTROPAOLO, J, MESHULAM, Y, JACOBSON, K. A

“…We have previously shown that acute preischemic adenosine A3 receptor stimulation results in an increased postischemic damage, while chronic stimulation of…”
Get full text

Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia by Von Lubitz, D K, Lin, R C, Melman, N, Ji, X D, Carter, M F, Jacobson, K A

“…The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown…”
Get more information

Adenosine in the treatment of stroke: yes, maybe, or absolutely not? by von Lubitz, D K

“…Agonist stimulation of adenosine A(1) receptors has been consistently shown to result in reduction of brain damage following experimentally induced global and…”
Get more information

Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory by Von Lubitz, D K, Paul, I A, Bartus, R T, Jacobson, K A

“…Spatial memory acquisition in Morris water maze was tested in C57BL/6 mice. Animals were injected once daily with different doses of either…”
Get more information

Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist by VON LUBITZ, D. K. J. E, BEENHAKKER, M, LIN, R. C.-S, CARTER, M. F, PAUL, I. A, BISCHOFBERGER, N, JACOBSON, K. A

“…Agonists of adenosine A1 receptors have been frequently proposed as candidates for clinical development in treatment of cerebral ischemia and stroke. Numerous…”
Get full text

Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice by Von Lubitz, D K, Paul, I A, Ji, X D, Carter, M, Jacobson, K A

“…The effect of chronic administration of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and the adenosine A1 antagonist…”
Get more information

Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils by Von Lubitz, Dag K.J.E., Lin, Rick C.-S., Paul, Ian A., Beenhakker, Mark, Boyd, Mellonie, Bischofberger, Norbert, Jacobson, Kenneth A.

“…Although adenosine receptor-based treatment of cerebral ischemia and other neurodegenerative disorders has been frequently advocated, cardiovascular side…”
Get full text

A novel treatment of global cerebral ischaemia with a glycine partial agonist by Von Lubitz, D K, Lin, R C, McKenzie, R J, Devlin, T M, McCabe, R T, Skolnick, P

“…Chronic treatment of gerbils with 1-aminocyclopropanecarboxylic acid (a high affinity, partial agonist at strychnine-insensitive glycine receptors) resulted in…”
Get more information

Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A 1 receptor agonist by Von Lubitz, Dag K.J.E, Lin, Rick C.-S, Bischofberger, Norbert, Beenhakker, Mark, Boyd, Mellonie, Lipartowska, Renata, Jacobson, Kenneth A

“…Although the selectivity and potency of adenosine amine congener (ADAC) at adenosine A 1 receptors are similar to other highly selective agonists at this…”
Get full text

Cyclohexyl adenosine protects against neuronal death following ischemia in the CA1 region of gerbil hippocampus by VON LUBITZ, K. J. E, DAMBROSIA, J. M, KEMPSKI, O, REDMOND, D. J

“…Sixty-five male gerbils were exposed to 30 minutes of cerebral ischemia induced by a bilateral carotid artery occlusion. One group of 15 gerbils received a…”
Get full text

Protective effect of cyclohexyl adenosine in treatment of cerebral ischemia in gerbils by Januszewicz von Lubitz, D K, Dambrosia, J M, Redmond, D J

“…The effect of postischemically injected cyclohexyl adenosine has been studied in gerbils. The animals were subjected to 30 min of bilateral carotid occlusion…”
Get more information

Cerebral ischaemia in the rat: increased permeability of post-synaptic membranes to horseradish peroxidase in the early post-ischaemic period by Diemer, N H, Ekström von Lubitz, D K

“…An earlier study of the rat hippocampal stratum radiatum after transient cerebral ischaemia has shown cell membrane breaks, mainly post-synaptically, occurring…”
Get more information