Search Results - "von Kügelgen, I"

Interaction of the active metabolite of prasugrel, R‐138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor by ALGAIER, I., JAKUBOWSKI, J. A., ASAI, F., VON KÜGELGEN, I.

“…Background: The P2Y12 receptor plays a crucial role in platelet aggregation and is the target of platelet aggregation inhibitors, including the thienopyridine…”
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A study of the mechanism of the release of ATP from rat cortical astroglial cells evoked by activation of glutamate receptors by Queiroz, G., Meyer, D.K., Meyer, A., Starke, K., von Kügelgen, I.

“…Glutamate and the selective agonists at ionotropic glutamate receptors N-methyl- d-aspartate, α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) and…”
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Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12‐receptor by Hoffmann, K., Lutz, D. A., Straßburger, J., Baqi, Y., Müller, C. E., Kügelgen, I.

“…Summary Background The G‐protein‐coupled P2Y12‐receptor plays a crucial role in platelet aggregation. Recently, ticagrelor was licensed as the first perorally…”
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Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation by Queiroz, G, Gebicke-Haerter, P.J, Schobert, A, Starke, K, von Kügelgen, I

“…The release of ATP was studied in cultures of astrocytes derived from the brain hemispheres of newborn rats. There was a basal efflux of ATP, which was…”
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Molecular pharmacology of P2Y-receptors by von Kügelgen, I, Wetter, A

“…Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-cell signalling. P2X-receptors are ligand-gated ion channels, whereas…”
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Adenosine A3 receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes by Hinze, A.V, Mayer, P, Harst, A, von Kügelgen, I

“…Abstract In human coronary smooth muscle cells adenosine A2B receptors mediate the inhibition of platelet-derived growth factor (PDGF)-induced proliferation…”
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Dual regulation of β2-adrenoceptor messenger RNA expression in human lung fibroblasts by β2–cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression by Kämpfer, N., Lamyel, F., Schütz, I., Warnken, M., Hoffmann, K., von Kügelgen, I., Racké, Kurt

“…Based on their bronchodilatory effect, β 2 -adrenoceptor agonists constitute essential elements in the treatment of bronchial asthma and COPD. As treatment…”
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M‐type K+ currents in rat cultured thoracolumbar sympathetic neurones and their role in uracil nucleotide‐evoked noradrenaline release by Nörenberg, W, Von Kügelgen, I, Meyer, A, Illes, P, Starke, K

“…Cultured sympathetic neurones are depolarized and release noradrenaline in response to extracellular ATP, UDP and UTP. We examined the possibility that, in…”
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Co-release of noradrenaline and ATP from cultured sympathetic neurons by von Kügelgen, I, Allgaier, C, Schobert, A, Starke, K

“…The vesicles of postganglionic sympathetic axons store both noradrenaline and ATP. The theory of noradrenaline-ATP co-transmission implies that both compounds…”
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P2-receptor-mediated inhibition of noradrenaline release in the rat hippocampus by Koch, H, von Kügelgen, I, Starke, K

“…Experiments on hippocampal slices were carried out in order to find out whether the release of noradrenaline in the hippocampus can be modulated through…”
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Molecular basis for the antiproliferative effect of agmatine in tumor cells of colonic, hepatic, and neuronal origin by Wolf, C, Brüss, M, Hänisch, B, Göthert, M, von Kügelgen, I, Molderings, G J

“…The aim of the present study was to challenge potential mechanisms of action underlying the inhibition of tumor cell proliferation by agmatine. Agmatine…”
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Noradrenaline and adenosine triphosphate as co-transmitters of neurogenic vasoconstriction in rabbit mesenteric artery by von Kügelgen, I, Starke, K

“…The largest rami caecales of the ileocolic artery, which is a branch of the mesenteric artery, were perfused at a constant rate of flow. Either…”
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P2-receptor-mediated inhibition of noradrenaline release in the rat pancreas by Koch, H, von Kügelgen, I, Starke, K

“…The aim of the study was to find out whether, and if so through which receptors, nucleotides modulate the release of noradrenaline in the rat pancreas…”
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Presynaptic modulation of the release of the co-transmitters noradrenaline and ATP by von Kügelgen, I, Kurz, K, Bültmann, R, Driessen, B, Starke, K

“…The release of both sympathetic co-transmitters, noradrenaline and ATP, is modulated via presynaptic receptors. However, the degree of the modulation may…”
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Axon terminal P2-purinoceptors in feedback control of sympathetic transmitter release by von Kügelgen, I, Kurz, K, Starke, K

“…Extracellular ATP acts on P2-purinoceptors of peripheral effector cells, and this is the basis for its function as a (co-)transmitter in peripheral efferent…”
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Role of action potentials and calcium influx in ATP- and UDP-induced noradrenaline release from rat cultured sympathetic neurones by von Kügelgen, I, Nörenberg, W, Meyer, A, Illes, P, Starke, K

“…Adenine and uracil nucleotides release noradrenaline from rat postganglionic sympathetic neurones by activation of P2X-receptors and distinct receptors for…”
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Nucleotides as cotransmitters in vascular sympathetic neuroeffector transmission by Starke, K, von Kügelgen, I, Bulloch, J M, Illes, P

“…Postganglionic sympathetic cotransmission by noradrenaline (NA) and adenosine 5'-triphosphate (ATP) was studied in isolated arteries from rabbits using as…”
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Differences in the mode of stimulation of cultured rat sympathetic neurons between ATP and UDP by VON KÜGELGEN, I, NÖRENBERG, W, ILLES, P, SCHOBERT, A, STARKE, K

“…Postganglionic sympathetic neurons possess at least two excitatory receptors for nucleotides: P2X-purinoceptors and separate receptors for uracil nucleotides…”
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P2‐purinoceptor‐mediated inhibition of noradrenaline release in rat atria by Kügelgen, Ivar, Stoffel, Daniel, Starke, Klaus

“…1 We looked for P2‐purinoceptors modulating noradrenaline release in rat heart atria. Segments of the atria were preincubated with [3H]‐noradrenaline and then…”
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Electrophysiological analysis of P2-receptor mechanisms in rat sympathetic neurones by Nörenberg, W, von Kügelgen, I, Meyer, A, Illes, P

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