Search Results - "von Hörsten, Stephan"

Proteolytic α-Synuclein Cleavage in Health and Disease by Bluhm, Alexandra, Schrempel, Sarah, von Hörsten, Stephan von, Schulze, Anja, Roßner, Steffen

“…In Parkinson’s disease, aggregates of α-synuclein within Lewy bodies and Lewy neurites represent neuropathological hallmarks. However, the cellular and…”
Get full text

A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter by Amato, Davide, Canneva, Fabio, Cumming, Paul, Maschauer, Simone, Groos, Dominik, Dahlmanns, Jana Katharina, Grömer, Teja W., Chiofalo, Lisa, Dahlmanns, Marc, Zheng, Fang, Kornhuber, Johannes, Prante, Olaf, Alzheimer, Christian, von Hörsten, Stephan, Müller, Christian P.

“…Antipsychotic drugs are effective interventions in schizophrenia. However, the efficacy of these agents often decreases over time, which leads to treatment…”
Get full text

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies by Hartlage-Rübsamen, Maike, Bluhm, Alexandra, Moceri, Sandra, Machner, Lisa, Köppen, Janett, Schenk, Mathias, Hilbrich, Isabel, Holzer, Max, Weidenfeller, Martin, Richter, Franziska, Coras, Roland, Serrano, Geidy E., Beach, Thomas G., Schilling, Stephan, von Hörsten, Stephan, Xiang, Wei, Schulze, Anja, Roßner, Steffen

“…Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is neuropathologically characterized by degeneration of dopaminergic neurons of the…”
Get full text

The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells by Le Cann, Kim, Foerster, Alec, Rösseler, Corinna, Erickson, Andelain, Hautvast, Petra, Giesselmann, Sebastian, Pensold, Daniel, Kurth, Ingo, Rothermel, Markus, Mattis, Virginia B., Zimmer-Bensch, Geraldine, von Hörsten, Stephan, Denecke, Bernd, Clarner, Tim, Meents, Jannis, Lampert, Angelika

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin gene. The…”
Get full text

Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats by Habermeyer, Johanna, Boyken, Janina, Harrer, Julia, Canneva, Fabio, Ratz, Veronika, Moceri, Sandra, Admard, Jakob, Casadei, Nicolas, Jost, Gregor, Bäuerle, Tobias, Frenzel, Thomas, Schmitz, Christoph, Schütz, Gunnar, Pietsch, Hubertus, von Hörsten, Stephan

“…Gadolinium based contrast agents (GBCAs) are widely used in clinical MRI since the mid-1980s. Recently, concerns have been raised that trace amounts of…”
Get full text

Suppression of Experimental Autoimmune Encephalomyelitis by Ghrelin by Theil, Michael-Mark, Miyake, Sachiko, Mizuno, Miho, Tomi, Chiharu, Croxford, J. Ludovic, Hosoda, Hiroshi, Theil, Julia, von Horsten, Stephan, Yokote, Hiroaki, Chiba, Asako, Lin, Youwei, Oki, Shinji, Akamizu, Takashi, Kangawa, Kenji, Yamamura, Takashi

“…Ghrelin is a recently identified gastric hormone that displays strong growth hormone-releasing activity mediated by the growth hormone secretagogue receptor…”
Get full text

Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5 by Plank, Anne-Christine, Frey, Stefan, Basedow, Lukas Andreas, Solati, Jalal, Canneva, Fabio, von Hörsten, Stephan, Kratz, Oliver, Moll, Gunther H., Golub, Yulia

“…In our previous study, we found that prenatal trauma exposure leads to an anxiety phenotype in mouse pups, characterized by increased corticosterone levels and…”
Get full text

Inhibition of CD26/Dipeptidyl Peptidase IV Enhances CCL11/Eotaxin-Mediated Recruitment of Eosinophils In Vivo by Forssmann, Ulf, Stoetzer, Carsten, Stephan, Michael, Kruschinski, Carsten, Skripuletz, Thomas, Schade, Jutta, Schmiedl, Andreas, Pabst, Reinhard, Wagner, Leona, Hoffmann, Torsten, Kehlen, Astrid, Escher, Sylvia E, Forssmann, Wolf-Georg, Elsner, Jorn, von Horsten, Stephan

“…Chemokines mediate the recruitment of leukocytes to the sites of inflammation. N-terminal truncation of chemokines by the protease dipeptidyl peptidase IV…”
Get full text

Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease by Nuber, Silke, Petrasch-Parwez, Elisabeth, Winner, Beate, Winkler, Jurgen, von Horsten, Stephan, Schmidt, Thorsten, Boy, Jana, Kuhn, Melanie, Nguyen, Huu P, Teismann, Peter, Schulz, Jorg B, Neumann, Manuela, Pichler, Bernd J, Reischl, Gerald, Holzmann, Carsten, Schmitt, Ina, Bornemann, Antje, Kuhn, Wilfried, Zimmermann, Frank, Servadio, Antonio, Riess, Olaf

“…Alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease. These disorders are…”
Get full text

Regulation of Expression and Function of Dipeptidyl Peptidase 4 (DP4), DP8/9, and DP10 in Allergic Responses of the Lung in Rats by Schade, Jutta, Stephan, Michael, Schmiedl, Andreas, Wagner, Leona, Niestroj, Andre J, Demuth, Hans-Ulrich, Frerker, Nadine, Klemann, Christian, Raber, Kerstin A, Pabst, Reinhard, von Horsten, Stephan

“…The expression of dipeptidyl peptidase 4 (DP4, CD26) affects T-cell recruitment to lungs in an experimental rat asthma model. Furthermore, the gene of the…”
Get full text

Early Postnatal Hyperalimentation Impairs Renal Function via SOCS-3 Mediated Renal Postreceptor Leptin Resistance by Alcazar, Miguel Angel Alejandre, Boehler, Eva, Rother, Eva, Amann, Kerstin, Vohlen, Christina, von Hörsten, Stephan, Plank, Christian, Dötsch, Jörg

“…Early postnatal hyperalimentation has long-term implications for obesity and developing renal disease. Suppressor of cytokine signaling (SOCS) 3 inhibits…”
Get full text

Postnatal Life Events Affect the Severity of Asthmatic Airway Inflammation in the Adult Rat by Kruschinski, Carsten, Skripuletz, Thomas, Bedoui, Sammy, Raber, Kerstin, Straub, Rainer H, Hoffmann, Torsten, Grote, Karsten, Jacobs, Roland, Stephan, Michael, Pabst, Reinhard, von Horsten, Stephan

“…Genetic and hygienic factors influence susceptibility to asthma. In autoimmune and inflammatory diseases, additional effects of the psychosocial environment…”
Get full text

Neuropeptide Y (NPY) Suppresses Experimental Autoimmune Encephalomyelitis: NPY1 Receptor-Specific Inhibition of Autoreactive Th1 Responses In Vivo by Bedoui, Sammy, Miyake, Sachiko, Lin, Youwei, Miyamoto, Katsuichi, Oki, Shinji, Kawamura, Noriyuki, Beck-Sickinger, Annette, von Horsten, Stephan, Yamamura, Takashi

“…Prior studies have revealed that the sympathetic nervous system regulates the clinical and pathological manifestations of experimental autoimmune…”
Get full text

Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis by Soare, Alina, Györfi, Hermina A., Matei, Alexandru E., Dees, Clara, Rauber, Simon, Wohlfahrt, Thomas, Chen, Chih‐Wei, Ludolph, Ingo, Horch, Raymund E., Bäuerle, Tobias, Hörsten, Stephan, Mihai, Carina, Distler, Oliver, Ramming, Andreas, Schett, Georg, Distler, Jörg H. W.

“…Objective Expression of dipeptidylpeptidase 4 (DPP‐4) identifies a dermal fibroblast lineage involved in scarring during wound healing. The role of DDP‐4 in…”
Get full text

Topical menthol, a pharmacological cold mimic, induces cold sensitivity, adaptive thermogenesis and brown adipose tissue activation in mice by Sankina, Polina, Lal, Roshan, Khare, Pragyanshu, Hörsten, Stephan, Fester, Lars, Aggarwal, Vaishali, Zimmermann, Katharina, Bishnoi, Mahendra

“…Aim Brown adipose tissue (BAT) thermogenesis has profound energy‐expanding potential, which makes it an attractive target tissue to combat ever‐increasing…”
Get full text

Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency by Schmiedl, Andreas, Wagener, Inga, Jungen, Meike, von Hörsten, Stephan, Stephan, Michael

“…Dipeptidyl-peptidase IV (CD26), a multifactorial integral type II protein, is expressed in the lungs during development and is involved in inflammation…”
Get full text

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro by Köppen, Janett, Schulze, Anja, Machner, Lisa, Wermann, Michael, Eichentopf, Rico, Guthardt, Max, Hähnel, Angelika, Klehm, Jessica, Kriegeskorte, Marie-Christin, Hartlage-Rübsamen, Maike, Morawski, Markus, von Hörsten, Stephan, Demuth, Hans-Ulrich, Roßner, Steffen, Schilling, Stephan

“…Alzheimer's disease (AD) and Parkinson's disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide…”
Get full text

Microvascular development in the rat arteriovenous loop model in vivo—A step by step intravital microscopy analysis by Vaghela, Ravikumar, Arkudas, Andreas, Gage, Daniel, Körner, Carolin, von Hörsten, Stephan, Salehi, Sahar, Horch, Raymund E., Hessenauer, Maximilian

“…The arteriovenous (AV) loop model is a key technique to solve one of the major problems of tissue engineering—providing adequate vascular support for a tissue…”
Get full text

Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease by Ratz-Wirsching, Veronika, Habermeyer, Johanna, Moceri, Sandra, Harrer, Julia, Schmitz, Christoph, von Hörsten, Stephan

“…In Huntington disease (HD) the prodromal phase has been increasingly investigated and is currently in focus for early interventional treatments. Also, the…”
Get full text

CatWalk XT gait parameters: a review of reported parameters in pre-clinical studies of multiple central nervous system and peripheral nervous system disease models by Timotius, Ivanna K, Roelofs, Reinko F, Richmond-Hacham, Bar, Noldus, Lucas P J J, von Hörsten, Stephan, Bikovski, Lior

“…Automated gait assessment tests are used in studies of disorders characterized by gait impairment. CatWalk XT is one of the first commercially available…”
Get full text