The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

This paper describes and discusses the methodology of the Nordic long-term OCD-treatment study (NordLOTS). The purpose of this effectiveness study was to study treatment outcome of CBT, to identify CBT non- or partial responders and to investigate whether an increased number of CBT-sessions or sertr...

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Bibliographic Details
Published in:	Child and adolescent psychiatry and mental health Vol. 7; no. 1; p. 41
Main Authors:	Thomsen, Per Hove, Torp, Nor C, Dahl, Kitty, Christensen, Karin, Englyst, Inger, Melin, Karin H, Nissen, Judith B, Hybel, Katja A, Valderhaug, Robert, Weidle, Bernhard, Skarphedinsson, Gudmundur, von Bahr, Petra Lindheim, Ivarsson, Tord
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 19-12-2013 BioMed Central
Subjects:	Adolescence Behavior therapy Care and treatment Child & adolescent psychiatry Child psychopathology Children & youth Cognition disorders Cognitive therapy Dosage and administration Drug therapy Medical research Medicine, Experimental Meetings Methods Neuroses Obsessive-compulsive disorder Outcome and process assessment (Health Care) Patient outcomes Sertraline Studies Denmark Norway Sweden
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Summary:	This paper describes and discusses the methodology of the Nordic long-term OCD-treatment study (NordLOTS). The purpose of this effectiveness study was to study treatment outcome of CBT, to identify CBT non- or partial responders and to investigate whether an increased number of CBT-sessions or sertraline treatment gives the best outcome; to identify treatment refractory patients and to investigate the outcome of aripiprazole augmentation; to study the outcome over a three year period for each responder including the risk of relapse, and finally to study predictors, moderators and mediators of treatment response. Step 1 was an open and uncontrolled clinical trial with CBT, step 2 was a controlled, randomised non-blinded study of CBT non-responders from step 1. Patients were randomized to receive either sertraline plus CBT-support or continued and modified CBT. In step 3 patients who did not respond to either CBT or sertraline were treated with aripiprazole augmentation to sertraline. This multicenter trial covering three Scandinavian countries is going to be the largest CBT-study for paediatric OCD to date. It is not funded by industry and tries in the short and long-term to answer the question whether further CBT or SSRI is better in CBT non-responders.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1753-2000 1753-2000
DOI:	10.1186/1753-2000-7-41