Search Results - "von Lieres, Eric"

Can enzyme proximity accelerate cascade reactions? by Kuzmak, Andrij, Carmali, Sheiliza, von Lieres, Eric, Russell, Alan J., Kondrat, Svyatoslav

“…The last decade has seen an exponential expansion of interest in conjugating multiple enzymes of cascades in close proximity to each other, with the…”
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Does metabolite channeling accelerate enzyme-catalyzed cascade reactions? by Poshyvailo, Liubov, von Lieres, Eric, Kondrat, Svyatoslav

“…Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next enzyme in a cascade. Among many potential advantages of…”
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Development and application of a cultivation platform for mammalian suspension cell lines with single‐cell resolution by Schmitz, Julian, Täuber, Sarah, Westerwalbesloh, Christoph, Lieres, Eric, Noll, Thomas, Grünberger, Alexander

“…In bioproduction processes, cellular heterogeneity can cause unpredictable process outcomes or even provoke process failure. Still, cellular heterogeneity is…”
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Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials by Sehl, Torsten, Hailes, Helen C., Ward, John M., Wardenga, Rainer, von Lieres, Eric, Offermann, Heike, Westphal, Robert, Pohl, Martina, Rother, Dörte

“…Two steps in one pot: An enzyme cascade consisting of a lyase and an (R)‐ or (S)‐selective ω‐transaminase (TA) provides (1R,2R)‐norpseudoephedrine and…”
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Analysis of the local well‐posedness of optimization‐constrained differential equations by local optimality conditions by Zhao, Xiao, Ploch, Tobias, Noack, Stephan, Wiechert, Wolfgang, Mitsos, Alexander, von Lieres, Eric

“…Optimization‐constrained differential equations (OCDE) are a class of mathematical problems where differential equations are constrained by an embedded…”
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Bayesian calibration, process modeling and uncertainty quantification in biotechnology by Helleckes, Laura Marie, Osthege, Michael, Wiechert, Wolfgang, von Lieres, Eric, Oldiges, Marco

“…High-throughput experimentation has revolutionized data-driven experimental sciences and opened the door to the application of machine learning techniques…”
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Multiscale dynamic modeling and simulation of a biorefinery by Ploch, Tobias, Zhao, Xiao, Hüser, Jonathan, Lieres, Eric, Hannemann‐Tamás, Ralf, Naumann, Uwe, Wiechert, Wolfgang, Mitsos, Alexander, Noack, Stephan

“…A biorefinery comprises a variety of process steps to synthesize products from sustainable natural resources. Dynamic plant‐wide simulation enhances the…”
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Laboratory-scale photobiotechnology-current trends and future perspectives by Morschett, Holger, Loomba, Varun, Huber, Gregor, Wiechert, Wolfgang, von Lieres, Eric, Oldiges, Marco

“…Phototrophic bioprocesses are a promising puzzle piece in future bioeconomy concepts but yet mostly fail for economic reasons. Besides other aspects, this is…”
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Effects of uncertainties in experimental conditions on the estimation of adsorption model parameters in preparative chromatography by Borg, Niklas, Westerberg, Karin, Andersson, Niklas, von Lieres, Eric, Nilsson, Bernt

“…•Two cases of chromatography are modeled and analyzed, ion exchange and reversed phase.•Uncertainties in concentrations are sampled and used in…”
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Influence of Organic Solvents on Enzymatic Asymmetric Carboligations by Gerhards, Tina, Mackfeld, Ursula, Bocola, Marco, von Lieres, Eric, Wiechert, Wolfgang, Pohl, Martina, Rother, Dörte

“…The asymmetric mixed carboligation of aldehydes with thiamine diphosphate (ThDP)‐dependent enzymes is an excellent example where activity as well as changes in…”
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Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips by Ho, Phuong, Westerwalbesloh, Christoph, Kaganovitch, Eugen, Grünberger, Alexander, Neubauer, Peter, Kohlheyer, Dietrich, Lieres, Eric von

“…Microbial cells in industrial large-scale bioreactors are exposed to fluctuating conditions, e.g., nutrient concentration, dissolved oxygen, temperature, and…”
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Chromatography Analysis and Design Toolkit (CADET) by Leweke, Samuel, von Lieres, Eric

“…•Open source public domain software freely available to academia and industry.•Wide range of transport and binding models for column liquid…”
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Machine learning in bioprocess development: from promise to practice by Helleckes, Laura M., Hemmerich, Johannes, Wiechert, Wolfgang, von Lieres, Eric, Grünberger, Alexander

“…Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess development provides large amounts of heterogeneous experimental…”
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Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications by Täuber, Sarah, Lieres, Eric, Grünberger, Alexander

“…Microfluidic single‐cell cultivation (MSCC) is an emerging field within fundamental as well as applied biology. During the last years, most MSCCs were…”
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Competitive adsorption of labeled and native protein in confocal laser scanning microscopy by Teske, Christopher A., Lieres, Eric von, Schröder, Magnus, Ladiwala, Asif, Cramer, Steven M., Hubbuch, Jürgen J.

“…Confocal laser scanning microscopy has been previously applied to the study of protein uptake in porous chromatography resins. This method requires labeling…”
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Patterns of protein adsorption in ion-exchange particles and columns: Evolution of protein concentration profiles during load, hold, and wash steps predicted for pore and solid diffusion mechanisms by Beck, Jürgen, von Lieres, Eric, Zaghi, Negar, Leweke, Samuel, Carta, Giorgio, Hahn, Rainer

“…•Artificial CSLM images to study intraparticle mass transfer effects.•Solid diffusion continues unhindered during hold and wash steps.•Different transport type…”
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Simulation of differential-algebraic equation systems with optimization criteria embedded in Modelica by Ploch, Tobias, Lieres, Eric von, Wiechert, Wolfgang, Mitsos, Alexander, Hannemann-Tamás, Ralf

“…Differential-algebraic equations with embedded optimization criteria (DAEO) are a class of mathematical models for underdetermined differential-algebraic…”
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Consecutive Three‐Component Synthesis of Phenothiazine‐Based Merocyanines – Bayesian Optimization, Electronic properties, and DSSC Characteristics by Stephan, Marvin, Stute, Birgit, Lieres, Eric, Müller, Thomas J. J.

“…A consecutive three‐component Heck‐Knoevenagel synthesis of phenothiazinyl merocyanines was developed by statistical design of experiments (DoE) and Bayesian…”
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Dynamic flux balance analysis with nonlinear objective function by Zhao, Xiao, Noack, Stephan, Wiechert, Wolfgang, Lieres, Eric von

“…Dynamic flux balance analysis (DFBA) extends flux balance analysis and enables the combined simulation of both intracellular and extracellular environments of…”
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Reliable cell retention of mammalian suspension cells in microfluidic cultivation chambers by Schmitz, Julian, Stute, Birgit, Täuber, Sarah, Kohlheyer, Dietrich, von Lieres, Eric, Grünberger, Alexander

“…Microfluidic cultivation, with its high level of environmental control and spatio-temporal resolution of cellular behavior, is a well-established tool in…”
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