Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions
Objective: To evaluate the changes in the number of Langerhans Cells (LC) observed in the epithelium of smokeless tobacco (SLT-induced) lesions. Methods: Microscopic sections from biopsies carried out in the buccal mucosa of twenty patients, who were chronic users of smokeless tobacco (SLT), were ut...
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| Published in: | Archives of Clinical and Experimental Surgery Vol. 1; no. 2; pp. 85 - 93 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
GESDAV
01-04-2012
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objective: To evaluate the changes in the number of Langerhans Cells (LC) observed in the epithelium of smokeless tobacco (SLT-induced) lesions. Methods: Microscopic sections from biopsies carried out in the buccal mucosa of twenty patients, who were chronic users of smokeless tobacco (SLT), were utilized. For the control group, twenty non-SLT users of SLT with normal mucosa were selected. The sections were studied with routine coloring and were immunostained for S-100, CD1a, Ki-67 and p63. These data were statistically analyzed by the Student's t-test to investigate the differences in the expression of immune markers in normal mucosa and in SLT-induced leukoplakia lesions. Results: There was a significant difference in the immunolabeling of all markers between normal mucosa and SLT-induced lesions (p<0.001). The leukoplakia lesions in chronic SLT users demonstrated a significant increase in the number of Langerhans cells and in the absence of epithelial dysplasia. Conclusion: The increase in the number of these cells represents the initial stage of leukoplakia. [Arch Clin Exp Surg 2012; 1(2.000): 85-93] |
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| ISSN: | 2146-8133 2146-8133 |
| DOI: | 10.5455/aces.20120229052919 |