Search Results - "van der Zon, Gerard C.M."

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38 by Ouwens, D.Margriet, de Ruiter, Nancy D., van der Zon, Gerard C.M., Carter, Andrew P., Schouten, Jan, van der Burgt, Corina, Kooistra, Klaas, Bos, Johannes L., Maassen, J.Antonie, van Dam, Hans

“…Transcription factor ATF2 regulates gene expression in response to environmental changes. Upon exposure to cellular stresses, the mitogen‐activated…”
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Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats by NASCIMENTO, Emmani B. M, FODOR, Mariann, DIAMANT, Michaela, MARGRIET OUWENS, D, VAN DER ZON, Gerard C. M, JAZET, Ingrid M, EDO MEINDERS, A, VOSHOL, Peter J, VLASBLOM, Ronald, BAAN, Bart, ECKEL, Jurgen, ANTONIE MAASSEN, J

“…Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats Emmani B.M…”
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A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men by Bakker, Leontine E H, van Schinkel, Linda D, Guigas, Bruno, Streefland, Trea C M, Jonker, Jacqueline T, van Klinken, Jan B, van der Zon, Gerard C M, Lamb, Hildo J, Smit, Johannes W A, Pijl, Hanno, Meinders, A Edo, Jazet, Ingrid M

“…South Asians (SAs) develop type 2 diabetes at a younger age and lower BMI compared with Caucasians (Cs). The underlying cause is still poorly understood but…”
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Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes by Bazuine, Merlijn, van der Zon, Gerard C.M, van de Ven, Rob, van den Broek, Peter J.A, Antonie Maassen, J

“…Recently, it was shown that rottlerin inhibits insulin-stimulated glucose uptake and reduces intracellular adenosine triphosphate (ATP) levels in 3T3-L1…”
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Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish by Hoeksma, Jelmer, van der Zon, Gerard C M, Ten Dijke, Peter, den Hertog, Jeroen

“…Zebrafish models are well-established tools for investigating the underlying mechanisms of diseases. Here, we identified cercosporamide, a metabolite from the…”
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An Insulin Receptor Mutant (Asp707→ Ala), Involved in Leprechaunism, Is Processed and Transported to the Cell Surface but Unable to Bind Insulin by Hart, Leen M.'t, Lindhout, Dick, Van der Zon, Gerard C.M., Kayserilli, Hülya, Apak, Memnune Y., Kleijer, Wim J., Van der Vorm, Eric R., Maassen, J. Antonie

“…We have identified a homozygous mutation near the carboxyl terminus of the insulin receptor (IR) α subunit from a leprechaun patient, changing Asp707 into Ala…”
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Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1 by Nascimento, Emmani B.M., Snel, Marieke, Guigas, Bruno, van der Zon, Gerard C.M., Kriek, Jan, Maassen, J. Antonie, Jazet, Ingrid M., Diamant, Michaela, Ouwens, D. Margriet

“…Type 2 diabetes is associated with alterations in protein kinase B (PKB/Akt) and mammalian target of rapamycin complex 1 (mTORC1) signalling. The proline-rich…”
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Middle-aged overweight South Asian men exhibit a different metabolic adaptation to short-term energy restriction compared with Europeans by Bakker, Leontine E. H., Guigas, Bruno, van Schinkel, Linda D., van der Zon, Gerard C. M., Streefland, Trea C. M., van Klinken, Jan B., Jonker, Jacqueline T., Lamb, Hildo J., Smit, Johannes W. A., Pijl, Hanno, Meinders, A. Edo, Jazet, Ingrid M.

“…Aims/hypothesis South Asians have a higher risk of developing type 2 diabetes than Europeans. The underlying cause of this excess risk is still poorly…”
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Proline-rich Akt substrate of 40-kDa contains a nuclear export signal by Wiza, Claudia, Nascimento, Emmani B.M., Linssen, Margot M.L., Carlotti, Françoise, Herzfeld de Wiza, Daniella, van der Zon, Gerard C.M., Maassen, J. Antonie, Diamant, Michaela, Guigas, Bruno, Ouwens, D. Margriet

“…The proline-rich Akt substrate of 40-kDa (PRAS40) has been linked to the regulation of the activity of the mammalian target of rapamycin complex 1 as well as…”
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The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells by Baan, Bart, van der Zon, Gerard C.M., Maassen, J. Antonie, Ouwens, D. Margriet

“…Growth factors activate ATF2 via sequential phosphorylation of Thr69 and Thr71, where the ATF2-Thr71-phosphorylation precedes the induction of ATF2-Thr69 +…”
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Permissive action of protein kinase C-ζ in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes by Luiken, Joost J F P, Ouwens, D Margriet, Habets, Daphna D J, van der Zon, Gerard C M, Coumans, Will A, Schwenk, Robert W, Bonen, Arend, Glatz, Jan F C

“…Insulin stimulates cardiac long-chain fatty acid (LCFA) and glucose uptake via translocation of human homolog of rat fatty acid translocase (CD36) and GLUT4…”
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Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes by Fleuren, Wilco W. M., Linssen, Margot M. L., Toonen, Erik J. M., van der Zon, Gerard C. M., Guigas, Bruno, de Vlieg, Jacob, Dokter, Wim H. A., Ouwens, D. Margriet, Alkema, Wynand

“…Abstract Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin…”
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The Role of c-Jun N-Terminal Kinase, p38, and Extracellular Signal-Regulated Kinase in Insulin-Induced Thr69 and Thr71 Phosphorylation of Activating Transcription Factor 2 by Baan, Bart, van Dam, Hans, van der Zon, Gerard C. M, Maassen, J. Antonie, Ouwens, D. Margriet

“…The stimulation of cells with physiological concentrations of insulin induces a variety of responses, e.g. an increase in glucose uptake, induction of glycogen…”
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Identification and Functional Assessment of Novel and Known Insulin Receptor Mutations in Five Patients with Syndromes of Severe Insulin Resistance by Maassen, J. Antonie, Tobias, Edward S., Kayserilli, Hülya, Tukel, Turgut, Yuksel-Apak, Memnune, d’Haens, Esther, Kleijer, Wim J., Féry, Francoise, van der Zon, Gerard C. M.

“…We analyzed the insulin receptor gene in four patients with leprechaunism and one with type A insulin resistance. We detected novel and previously reported…”
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Expression, Enzyme Activity, and Subcellular Localization of Mammalian Target of Rapamycin in Insulin-Responsive Cells by Withers, Dominic J., Ouwens, D.Margriet, Nave, Barbara T., van der Zon, Gerard C.M., Alarcon, Clara M., Cardenas, Maria E., Heitman, Joseph, Maassen, J.Antonie, Shepherd, Peter R.

“…The role of the mammalian target of rapamycin (mTOR) was investigated in insulin responsive cell lines. mTOR was expressed at high levels in insulin responsive…”
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Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2 by Ouwens, D.Margriet, van der Zon, Gerard C.M., Maassen, J.Antonie

“…We have examined the requirement of the protein tyrosine phosphatase Src Homology Phosphatase 2 (SHP2) for insulin-stimulated glycogen synthesis. To this end,…”
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Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D by Ouwens, D M, Mikkers, H M, van der Zon, G C, Stein-Gerlach, M, Ullrich, A, Maassen, J A

“…Insulin stimulation of fibroblasts rapidly induces the tyrosine dephosphorylation of proteins of 68 kDa and 125 kDa, in addition to the tyrosine…”
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Replacement of the Conserved Tyrosine 1210 by Phenylalanine in the Insulin Receptor Affects Insulin-Induced Dephosphorylation of Focal Adhesion Kinase but Leaves Other Responses Intact by Van der Zon, Gerard C. M, Ouwens, D. Margriet, Dorrestijn, Jannette, Maassen, J. Antonie

“…The families of tyrosine and serine/threonine kinases exhibit shared clusters of conserved amino acid residues. Some conserved residues are confined to the…”
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An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport by van der Vorm, E R, van der Zon, G C, MɆller, W, Krans, H M, Lindhout, D, Maassen, J A

“…In a patient with Leprechaunism, we have characterized a new mutation in the insulin receptor substituting Arg for Gly at position 31. The proband, the mother,…”
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A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface by Maassen, J. Antonie, Van der Vorm, Eric R, Van der Zon, Gerard C. M, Klinkhamer, Marc P, Krans, H. Michiel J, Moller, W

“…We have previously shown that a homozygous mutation encoding a substitution of proline for leucine at position 233 in the insulin receptor is linked with the…”
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