Search Results - "van der Wouden, Petra"

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells by Xiao, Zhangping, Song, Shanshan, Chen, Deng, Merkerk, Ronald, Wouden, Petra E., Cool, Robbert H., Quax, Wim J., Poelarends, Gerrit J., Melgert, Barbro N., Dekker, Frank J.

“…Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that play key roles in inflammation and cancer. Current strategies to…”
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A next-generation sequencing method for gene doping detection that distinguishes low levels of plasmid DNA against a background of genomic DNA by de Boer, Eddy N., van der Wouden, Petra E., Johansson, Lennart F., van Diemen, Cleo C., Haisma, Hidde J.

“…Gene doping confers health risks for athletes and is a threat to fair competition in sports. Therefore the anti-doping community has given attention on its…”
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De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system by Bosveld, Floris, Rana, Anil, van der Wouden, Petra E., Lemstra, Willy, Ritsema, Martha, Kampinga, Harm H., Sibon, Ody C. M.

“…In a forward genetic screen in Drosophila melanogaster, aimed to identify genes required for normal locomotor function, we isolated dPPCS (the second enzyme of…”
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Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC) by Cao, Fangyuan, de Weerd, Sander, Chen, Deng, Zwinderman, Martijn R.H., van der Wouden, Petra E., Dekker, Frank J.

“…Histone deacetylases (HDACs) play important roles in inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD). Unravelling of and…”
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Histone Deacetylase 3‐Directed PROTACs Have Anti‐inflammatory Potential by Blocking Polarization of M0‐like into M1‐like Macrophages by Zhao, Chunlong, Chen, Shipeng, Chen, Deng, Río‐Bergé, Clàudia, Zhang, Jianqiu, Van Der Wouden, Petra E., Daemen, Toos, Dekker, Frank J.

“…Abstract Macrophage polarization plays a crucial role in inflammatory processes. The histone deacetylase 3 (HDAC3) has a deacetylase‐independent function that…”
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Identification of a Bromodomain‐like Region in 15‐Lipoxygenase‐1 Explains Its Nuclear Localization by Chen, Deng, Xiao, Zhangping, Guo, Hao, Gogishvili, Dea, Setroikromo, Rita, Wouden, Petra E., Dekker, Frank J.

“…Lipoxygenase (LOX) activity provides oxidative lipid metabolites, which are involved in inflammatory disorders and tumorigenesis. Activity‐based probes to…”
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Light-controlled inhibition of BRAFV600E kinase by Hoorens, Mark W.H., Ourailidou, Maria E., Rodat, Theo, van der Wouden, Petra E., Kobauri, Piermichele, Kriegs, Malte, Peifer, Christian, Feringa, Ben L., Dekker, Frank J., Szymanski, Wiktor

“…Metastatic melanoma is amongst the most difficult types of cancer to treat, with current therapies mainly relying on the inhibition of the BRAFV600E mutant…”
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HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice by Leus, Niek G. J., van den Bosch, Thea, van der Wouden, Petra E., Krist, Kim, Ourailidou, Maria E., Eleftheriadis, Nikolaos, Kistemaker, Loes E. M., Bos, Sophie, Gjaltema, Rutger A. F., Mekonnen, Solomon A., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.

“…Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets…”
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Thieno[2,3‑d]pyrimidine-2,4(1H,3H)‑dione Derivative Inhibits d‑Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells by Xiao, Zhangping, Osipyan, Angelina, Song, Shanshan, Chen, Deng, Schut, Reinder A, van Merkerk, Ronald, van der Wouden, Petra E, Cool, Robbert H, Quax, Wim J, Melgert, Barbro N, Poelarends, Gerrit J, Dekker, Frank J

“…The homologous cytokines macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding…”
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Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos by Chen, Deng, Osipyan, Angelina, Adriana, Jeaunice, Kader, Mohammed, Gureev, Maxim, Knol, Catharina W. J., Sigmund, Marie-Cathérine, Xiao, Zhangping, van der Wouden, Petra E., Cool, Robbert H., Poelarends, Gerrit J., Dekker, Frank J.

“…Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and essential signaling protein associated with inflammation and cancers. One of the…”
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HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity by Leus, Niek G.J., van der Wouden, Petra E., van den Bosch, Thea, Hooghiemstra, Wouter T.R., Ourailidou, Maria E., Kistemaker, Loes E.M., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.

“…[Display omitted] The increasing number of patients suffering from chronic obstructive pulmonary disease (COPD) represents a major and increasing health…”
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The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors by Osipyan, Angelina, Bulai, Radu-George, Wu, Zhengyang, de Witte, Jarno, van der Velde, Jesse J.H., Kader, Mohammed, van der Wouden, Petra E., Poelarends, Gerrit J., Dekker, Frank J.

“…Despite recent advances in the treatment of cancer, the issue of therapy resistance remains one of the most significant challenges in the field. In this…”
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7‑Hydroxycoumarins Are Affinity-Based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor by Xiao, Zhangping, Chen, Deng, Song, Shanshan, van der Vlag, Ramon, van der Wouden, Petra E, van Merkerk, Ronald, Cool, Robbert H, Hirsch, Anna K. H, Melgert, Barbro N, Quax, Wim J, Poelarends, Gerrit J, Dekker, Frank J

“…Macrophage migration inhibitory factor (MIF) is a cytokine with key roles in inflammation and cancer, which qualifies it as a potential drug target. Apart from…”
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Rational Development of a Potent 15-Lipoxygenase‑1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties by Eleftheriadis, Nikolaos, Neochoritis, Constantinos G., Leus, Niek G. J., van der Wouden, Petra E., Dömling, Alexander, Dekker, Frank J.

“…Human 15-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygenase and plays an important role in several inflammatory lung diseases such as asthma, COPD, and…”
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4‐Iodopyrimidine Labeling Reveals Nuclear Translocation and Nuclease Activity for Both MIF and MIF2 by Xiao, Zhangping, Chen, Deng, Mulder, Fabian, Song, Shanshan, Wouden, Petra E., Cool, Robbert H., Melgert, Barbro N., Poelarends, Gerrit J., Dekker, Frank J.

“…Macrophage migration inhibitory factor (MIF) and its homolog MIF2 (also known as D‐dopachrome tautomerase or DDT) play key roles in cell growth and immune…”
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Enzyme kinetics and inhibition of histone acetyltransferase KAT8 by Wapenaar, Hannah, van der Wouden, Petra E., Groves, Matthew R., Rotili, Dante, Mai, Antonello, Dekker, Frank J.

“…Lysine acetyltransferase 8 (KAT8) is a histone acetyltransferase (HAT) responsible for acetylating lysine 16 on histone H4 (H4K16) and plays a role in cell…”
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Novel 15-Lipoxygenase‑1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity by Guo, Hao, Verhoek, Iris C, Prins, Gerian G. H, van der Vlag, Ramon, van der Wouden, Petra E, van Merkerk, Ronald, Quax, Wim J, Olinga, Peter, Hirsch, Anna K. H, Dekker, Frank J

“…Various mechanisms for regulated cell death include the formation of oxidative mediators such as lipid peroxides and nitric oxide (NO). In this respect,…”
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Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions by Zwinderman, Martijn R. H, Lobo, Thamar Jessurun, van der Wouden, Petra E, Spierings, Diana C. J, van Vugt, Marcel A. T. M, Lansdorp, Peter M, Guryev, Victor, Dekker, Frank J

“…Following DNA replication, equal amounts of chromatin proteins are distributed over sister chromatids by re-deposition of parental chromatin proteins and…”
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Protocol of the Double-Click Seq Method to Evaluate the Deposition Bias of Chromatin Proteins by van der Wouden, Petra E, Zwinderman, Martijn R H, Chen, Deng, Borghesan, Michela, Dekker, Frank J

“…Symmetrical deposition of parental and newly synthesized chromatin proteins over both sister chromatids is important for the maintenance of epigenetic…”
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The relevance of K i calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor by Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G J, van der Wouden, Petra E, Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J, Dekker, Frank J

“…Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and…”
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