Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene

Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene

Dendritic cells (DCs) play an importnt role in the induction of antigen-specific immune responses. Immature DCs capture antigens in peripheral tissues and subsequently migrate to the T-cell areas of secondary lymphoid organs to present these antigens to naive T and B cells. The DC-specific transmemb...

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Bibliographic Details
Published in:Immunogenetics (New York) Vol. 53; no. 2; pp. 145 - 149
Main Authors: Hartgers, F C, Looman, M W, van der Woning, B, Merkx, G F, Figdor, C G, Adema, G J
Format: Journal Article
Language:English
Published: United States 01-03-2001
Subjects:
Alternative Splicing
Amino Acid Sequence
Animals
Base Sequence
Cell Differentiation
Chromosome Mapping
Chromosomes, Human, Pair 8 - genetics
DC-STAMP gene
Dendritic Cells - cytology
Dendritic Cells - immunology
Dendritic Cells - metabolism
DNA, Complementary - genetics
Exons
Genome, Human
Humans
Introns
Membrane Proteins - genetics
Molecular Sequence Data
Promoter Regions, Genetic
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Summary:Dendritic cells (DCs) play an importnt role in the induction of antigen-specific immune responses. Immature DCs capture antigens in peripheral tissues and subsequently migrate to the T-cell areas of secondary lymphoid organs to present these antigens to naive T and B cells. The DC-specific transmembrane (TM) protein (DC-STAMP) is a novel TM molecule preferentially expressed by DCs that was identified by random sequencing of DC cDNA libraries. DC-STAMP is expressed by both immature and mature DCs, and its expression is downregulated by ligation of the CD40 molecule. The protein contains several putative TM regions, and has an intracellular C-terminus. Surprisingly, no sequence homology was found with any other protein or multimembrane-spanning receptor, indicating that DC-STAMP represents a new group of TM proteins. In this study, we cloned the DC-STAMP gene and characterized its genomic structure and chromosomal location.
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ISSN:0093-7711
1432-1211
DOI:10.1007/s002510100302