Search Results - "van der Westhuyzen, Aletta E."

New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells by Ingels, Aude, Scott, Robert, Hooper, Annie R., van der Westhuyzen, Aletta E., Wagh, Sachin B., de Meester, Joséphine, Maddau, Lucia, Marko, Doris, Aichinger, Georg, Berger, Walter, Vermeersch, Marjorie, Pérez-Morga, David, Maslivetc, Vladimir A., Evidente, Antonio, van Otterlo, Willem A. L., Kornienko, Alexander, Mathieu, Véronique

“…Sphaeropsidins are iso -pimarane diterpenes produced by phytopathogenic fungi that display promising anticancer activities. Sphaeropsidin A, in particular, has…”
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Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7‑Deazahypoxanthine C7/C8 Ring Systems by van der Westhuyzen, Aletta E., Ashraf, Naghmana, Conradie, Daleen, Loots, Leigh, Kaschula, Catherine H., Pelly, Stephen C., Frolova, Liliya V., Landfair, Taylor, Shuster, Charles B., Betancourt, Tania, Kornienko, Alexander, van Otterlo, Willem A. L.

“…To improve their aqueous solubility characteristics, water-solubilizing groups were added to some antiproliferative, rigidin-inspired 7-deazahypoxanthine…”
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Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury by Fritzemeier, Russell G., van der Westhuyzen, Aletta E., D’Erasmo, Michael, Sharma, Savita K., Bartsch, Perry, Hodson, Luke E., Liu, Ken, Wali, Bushra, Sayeed, Iqbal, Liotta, Dennis C.

“…The C-20 oxime of progesterone, EIDD-036 (2), demonstrates neuroprotection and improved outcomes in animal models of traumatic brain injury (TBI). However, 2…”
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The Rigidins: Isolation, Bioactivity, and Total Synthesis-Novel Pyrrolo[2,3-d]Pyrimidine Analogues Using Multicomponent Reactions by van der Westhuyzen, Aletta E, Frolova, Liliya V, Kornienko, Alexander, van Otterlo, Willem A L

“…Rigidins (2-6) are pyrrolopyrimidine alkaloids isolated from marine tunicates. Since their isolation, refinement of their total syntheses, and biochemical…”
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