Search Results - "van der Walle, C F"

Specific Ion and Buffer Effects on Protein–Protein Interactions of a Monoclonal Antibody by Roberts, D, Keeling, R, Tracka, M, van der Walle, C. F, Uddin, S, Warwicker, J, Curtis, R

“…Better predictive ability of salt and buffer effects on protein–protein interactions requires separating out contributions due to ionic screening, protein…”
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Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers by Madeira do O, J, Foralosso, R, Yilmaz, G, Mastrotto, F, King, P J S, Xerri, R M, He, Y, van der Walle, C F, Fernandez-Trillo, F, Laughton, C A, Styliari, I, Stolnik, S, Mantovani, G

“…Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that…”
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A freeze-dried formulation of bacteriophage encapsulated in biodegradable microspheres by Puapermpoonsiri, U., Spencer, J., van der Walle, C.F.

“…With the emergence of widespread antibiotic resistance, there has been renewed interest in the use of bacteriophages. While their potency, safety and…”
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The influence of surfactant on PLGA microsphere glass transition and water sorption : Remodeling the surface morphology to attenuate the burst release by BOUISSOU, C, ROUSE, J. J, PRICE, R, VAN DER WALLE, C. F

“…The stability of protein unloaded and loaded poly(lactic-co-glycolic acid) (PLGA) microspheres fabricated with surfactant was challenged through exposure to…”
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Stabilization of bacteriophage during freeze drying by Puapermpoonsiri, U., Ford, S.J., van der Walle, C.F.

“…With preliminary clinical trials completed for the treatment of antibiotic resistant infections using bacteriophages, there is a need to develop…”
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The Role of Electrostatics in Protein–Protein Interactions of a Monoclonal Antibody by Roberts, D, Keeling, R, Tracka, M, van der Walle, C. F, Uddin, S, Warwicker, J, Curtis, R

“…Understanding how protein–protein interactions depend on the choice of buffer, salt, ionic strength, and pH is needed to have better control over protein…”
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Engineering silica particles as oral drug delivery vehicles by Rigby, S P, Fairhead, M, van der Walle, C F

“…Porous silica particles are emerging as complementary systems to polyester microspheres for the encapsulation and controlled delivery of small-organic drugs…”
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Microemulsions for oral delivery of insulin: Design, development and evaluation in streptozotocin induced diabetic rats by Sharma, G., Wilson, K., van der Walle, C.F., Sattar, N., Petrie, J.R., Ravi Kumar, M.N.V.

“…Insulin-loaded microemulsions made by a reverse micellar approach improve the oral bioavailability of insulin with modest effects on blood glucose levels in…”
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Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host-guest chemistry by Gubeli, R J, Sonzini, S, Podmore, A, Ravn, P, Scherman, O A, van der Walle, C F

“…The combination of potent chemical moieties with biologically active proteins is key to some of today's most innovative therapeutic drugs. In order to obviate…”
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Physical ageing and thermal analysis of PLGA microspheres encapsulating protein or DNA by Rouse, J.J., Mohamed, F., van der Walle, C.F.

“…PLGA microspheres undergo physical ageing but their ageing kinetics have not been reported, nor the effect of encapsulated protein or plasmid DNA on any…”
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Tight junction modulation and biochemical characterisation of the zonula occludens toxin C-and N-termini by Schmidt, E., Kelly, S.M., van der Walle, C.F.

“…The ZOT N-terminal domain was expressed and refolded, yielding a soluble protein with defined secondary structure. Although distantly related to protein I of…”
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Micro- and macro-viscosity relations in high concentration antibody solutions by Shah, M., Corbett, D., Lanzaro, A., Roche, A., Sibanda, N., Davis, P., Uddin, S., van der Walle, C.F., Curtis, R., Pluen, A.

“…[Display omitted] Molecular crowding in highly concentrated monoclonal antibody (mAb) solutions results in significant increases in viscosity, which…”
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Solution formulation and lyophilisation of a recombinant fibronectin fragment by Pereira, P., Kelly, S.M., Cooper, A., Mardon, H.J., Gellert, P.R., van der Walle, C.F.

“…The 9th–10th type III fibronectin domain pair shows promise in tissue engineering and tumour vasculature targeting. Calorimetry and structure–function analysis…”
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Interdomain mobility and conformational stability of type III fibronectin domain pairs control surface adsorption, desorption and unfolding by Pereira, P., Kelly, S.M., Gellert, P.R., van der Walle, C.F.

“…The 9th–10th type III fibronectin domain pair ( 9–10FNIII) has found widespread use as a biomimetic surface for cell adhesion. However, the effect of mutations…”
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Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: Development, pharmacokinetics, biodistribution and pharmacodynamics by Sharma, G., van der Walle, C.F., Ravi Kumar, M.N.V.

“…The in vitro/in vivo characterization of antacid-insulin co-encapsulated poly(lactide-co-glycolide) (PLGA) nanoparticles is presented here. The optimized…”
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Investigations of structural requirements for endothelin antagonism by van der Walle, C F, Barlow, D J

“…Following the isolation of the vasoactive peptide, endothelin (ET), considerable effort has been expended in the development of ET antagonists, some of which…”
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Solution-structure of a Peptide Designed to Mimic the C-terminal Hexapeptide of Endothelin by VAN DER WALLE, C. F., BANSAL, S., BARLOW, D. J.

“…The peptide: Ac‐cyclo(Cys‐His‐Leu‐Asp‐Cys)‐Ile‐Trp‐OH, has been designed by computer‐aided molecular‐modelling techniques to mimic the proposed α‐helical…”
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A tetravalent RGD ligand for integrin-mediated cell adhesion by Watson, N., Duncan, G., Annan, W. S., van der Walle, C. F.

“…Monovalent RGD (arginine‐glycine‐aspartic acid) peptides or polymers furnished with RGD in random distributions are employed as cell‐scaffolds and gene…”
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Self-assembling multimeric integrin alpha 5 beta 1 ligands for cell attachment and spreading by Kreiner, M, Li, Z, Beattie, J, Kelly, S M, Mardon, HJ, van der Walle, CF

“…Substrates utilising clustered arginine-glycine-aspartic acid (RGD) ligand displays support greater cell adhesion over random displays. However, cell adhesion…”
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Determining drug spatial distribution within controlled delivery tablets using MFX imaging by Rigby, Sean P., Van der Walle, Christopher F., Raistrick, James H.

“…In this study, the potential of micro-focus X-ray (MFX) imaging as a tool in the design and quality control of drug delivery systems has been demonstrated. MFX…”
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