Search Results - "van der Ven, Leo T. M"

Long-Term Exposure to Environmental Concentrations of the Pharmaceutical Ethynylestradiol Causes Reproductive Failure in Fish by Nash, Jon P., Kime, David E., Leo T. M. Van der Ven, Wester, Piet W., Brion, François, Maack, Gerd, Stahlschmidt-Allner, Petra, Tyler, Charles R.

“…Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations,…”
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Practical Application of Next Generation Risk Assessment of Chemicals for Human Health by Luijten, Mirjam, Rorije, Emiel, Sprong, R. Corinne, van der Ven, Leo T. M

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Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds by Staal, Yvonne C. M., Meijer, Jeroen, van der Kris, Remco J. C., de Bruijn, Annamaria C., Boersma, Anke Y., Gremmer, Eric R., Zwart, Edwin P., Beekhof, Piet K., Slob, Wout, van der Ven, Leo T. M.

“…The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals…”
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Effects of the Antithyroid Agent Propylthiouracil in a Partial Life Cycle Assay with Zebrafish by van der Ven, Leo T. M, van den Brandhof, Evert-Jan, Vos, José H, Power, Deborah M, Wester, Piet W

“…Some ubiquitous pollutants of the aquatic environment, such as PCBs or other polyhalogenated aromatic hydrocarbons, may disrupt the thyroid hormone system. In…”
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A 28-Day Oral Dose Toxicity Study Enhanced to Detect Endocrine Effects of Hexabromocyclododecane in Wistar Rats by van der Ven, Leo T. M., Verhoef, Aart, van de Kuil, Ton, Slob, Wout, Leonards, Pim E. G., Visser, Theo J., Hamers, Timo, Herlin, Maria, Håkansson, Helen, Olausson, Hanna, Piersma, Aldert H., Vos, Josephus G.

“…A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed…”
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Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study by Van der Ven, Leo T.M, Van de Kuil, Ton, Verhoef, Aart, Verwer, Cynthia M, Lilienthal, Hellmuth, Leonards, Pim E.G, Schauer, Ute M.D, Cantón, Rocío F, Litens, Sabina, De Jong, Frank H, Visser, Theo J, Dekant, Wolfgang, Stern, Natalia, Håkansson, Helen, Slob, Wout, Van den Berg, Martin, Vos, Josephus G, Piersma, Aldert H

“…Abstract Endocrine effects of the brominated flame retardant tetrabromobisphenol-A (TBBPA) were studied in a one-generation reproduction assay in Wistar rats…”
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Identification of Hydroxylated Metabolites of Hexabromocyclododecane in Wildlife and 28-days Exposed Wistar Rats by Brandsma, Sicco H, van der Ven, Leo T.M, de Boer, Jacob, Leonards, Pim E.G

“…We studied the presence of hydroxylated metabolites of hexabromocyclododecane (HBCD) in three wildlife species (tern egg, seal, and flounder) and in Wistar…”
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Exploring Neurobehaviour in Zebrafish Embryos as a Screening Model for Addictiveness of Substances by Havermans, Anne, Zwart, Edwin P., Cremers, Hans W. J. M., van Schijndel, Maarten D. M., Constant, Romy S., Mešković, Maja, Worutowicz, Laura X., Pennings, Jeroen L. A., Talhout, Reinskje, van der Ven, Leo T. M., Heusinkveld, Harm J.

“…Tobacco use is the leading cause of preventable death worldwide and is highly addictive. Nicotine is the main addictive compound in tobacco, but less is known…”
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Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals by Hermsen, Sanne A.B., Pronk, Tessa E., van den Brandhof, Evert-Jan, van der Ven, Leo T.M., Piersma, Aldert H.

“…The zebrafish embryotoxicity test (ZET) is an alternative test to predict embryotoxicity of substances based on morphological assessment. Implementing…”
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A Case Study with Triazole Fungicides to Explore Practical Application of Next-Generation Hazard Assessment Methods for Human Health by van der Ven, Leo T. M, Rorije, Emiel, Sprong, R. Corinne, Zink, Daniele, Derr, Remco, Hendriks, Giel, Loo, Lit-Hsin, Luijten, Mirjam

“…The ongoing developments in chemical risk assessment have led to new concepts building on integration of sophisticated nonanimal models for hazard…”
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Hepatic effects of a highly purified 2,2′,3,4,4′,5,5′-heptachlorbiphenyl (PCB 180) in male and female rats by Roos, Robert, Andersson, Patrik L, Halldin, Krister, Hǻkansson, Helen, Westerholm, Emma, Hamers, Timo, Hamscher, Gerd, Heikkinen, Päivi, Korkalainen, Merja, Leslie, Heather A, Niittynen, Marjo, Sankari, Satu, Schmitz, Hans-Joachim, van der Ven, Leo T.M, Viluksela, Matti, Schrenk, Dieter

“…Highlights ► A highly purified PCB 180 was applied to male and female rats by gavage over 28 days. ► Induction of hepatic CYP2B1/2 and 3A1 was measured on the…”
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OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing by Busquet, François, Strecker, Ruben, Rawlings, Jane M., Belanger, Scott E., Braunbeck, Thomas, Carr, Gregory J., Cenijn, Peter, Fochtman, Przemyslaw, Gourmelon, Anne, Hübler, Nicole, Kleensang, André, Knöbel, Melanie, Kussatz, Carola, Legler, Juliette, Lillicrap, Adam, Martínez-Jerónimo, Fernando, Polleichtner, Christian, Rzodeczko, Helena, Salinas, Edward, Schneider, Katharina E., Scholz, Stefan, van den Brandhof, Evert-Jan, van der Ven, Leo T.M., Walter-Rohde, Susanne, Weigt, Stefan, Witters, Hilda, Halder, Marlies

“…•Zebrafish embryo acute toxicity test (ZFET) validated for aquatic toxicity testing.•20 chemicals tested in 11 laboratories with standardised ZFET…”
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Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies by Hermsen, Sanne A.B., van den Brandhof, Evert-Jan, van der Ven, Leo T.M., Piersma, Aldert H.

“…The zebrafish embryotoxicity test (ZET) is a fast and simple method to study chemical toxicity after exposure of the complete vertebrate embryo during…”
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Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test by Atzei, Alessandro, Jense, Ingrid, Zwart, Edwin P., Legradi, Jessica, Venhuis, Bastiaan J., van der Ven, Leo T.M., Heusinkveld, Harm J., Hessel, Ellen V.S.

“…Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an…”
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Zebrafish embryos as a screen for DNA methylation modifications after compound exposure by Bouwmeester, Manon C., Ruiter, Sander, Lommelaars, Tobias, Sippel, Josefine, Hodemaekers, Hennie M., van den Brandhof, Evert-Jan, Pennings, Jeroen L.A., Kamstra, Jorke H., Jelinek, Jaroslav, Issa, Jean-Pierre J., Legler, Juliette, van der Ven, Leo T.M.

“…Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of…”
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Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling by Driessen, Marja, Kienhuis, Anne S., Pennings, Jeroen L. A., Pronk, Tessa E., van de Brandhof, Evert-Jan, Roodbergen, Marianne, Spaink, Herman P., van de Water, Bob, van der Ven, Leo T. M.

“…The whole zebrafish embryo model (ZFE) has proven its applicability in developmental toxicity testing. Since functional hepatocytes are already present from 36…”
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A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen by Driessen, Marja, Vitins, Alexa P., Pennings, Jeroen L.A., Kienhuis, Anne S., Water, Bob van de, van der Ven, Leo T.M.

“…The zebrafish embryo (ZFE) is a promising alternative, non-rodent model in toxicology, which has an advantage over the traditionally used models as it contains…”
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Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models by Vitins, Alexa P., Kienhuis, Anne S., Speksnijder, Ewoud N., Roodbergen, Marianne, Luijten, Mirjam, van der Ven, Leo T. M.

“…Liver injury is the leading cause of drug-induced toxicity. For the evaluation of a chemical compound to induce toxicity, in this case steatosis or fatty…”
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Prioritization of chemicals in food for risk assessment by integrating exposure estimates and new approach methodologies: A next generation risk assessment case study by Luijten, Mirjam, Sprong, R. Corinne, Rorije, Emiel, van der Ven, Leo T. M.

“…Next generation risk assessment is defined as a knowledge-driven system that allows for cost-efficient assessment of human health risk related to chemical…”
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Triazole-induced gene expression changes in the zebrafish embryo by Hermsen, Sanne A.B., Pronk, Tessa E., van den Brandhof, Evert-Jan, van der Ven, Leo T.M., Piersma, Aldert H.

“…► We used the zebrafish embryotoxicity test in combination with transcriptomics. ► We tested five triazole anti-fungals in a single concentration and one in a…”
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