Search Results - "van der Velden, Adrianus W M"

Inflammatory monocytes provide a niche for Salmonella expansion in the lumen of the inflamed intestine by McLaughlin, Patrick A, Bettke, Julie A, Tam, Jason W, Leeds, Jesse, Bliska, James B, Butler, Brian P, van der Velden, Adrianus W M

“…Salmonella exploit host-derived nitrate for growth in the lumen of the inflamed intestine. The generation of host-derived nitrate is dependent on Nos2, which…”
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Recruitment of Rab27a to Phagosomes Controls Microbial Antigen Cross-Presentation by Dendritic Cells by Kim, Seong Hyun, Visser, Annelies, Cruijsen, Carin, van der Velden, Adrianus W.M, Boes, Marianne

“…Polyreactive immunoglobulins (Ig) and complement components are present in tissues and blood of healthy individuals. They facilitate pathogen uptake and…”
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Phenotypic, Morphological, and Functional Heterogeneity of Splenic Immature Myeloid Cells in the Host Response to Tularemia by RASMUSSEN, John W, TAM, Jason W, OKAN, Nihal A, MENA, Patricio, FURIE, Martha B, THANASSI, David G, BENACH, Jorge L, DER VELDEN, Adrianus W. M. Van

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Salmonella Inhibit T Cell Proliferation by a Direct, Contact-Dependent Immunosuppressive Effect by Adrianus W. M. van der Velden, Michael K. Copass, Starnbach, Michael N.

“…Dendritic cells (DC) are of central importance in the initiation of T cell-mediated adaptive immunity because these professional phagocytes internalize,…”
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IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity by Gaudino, Stephen J., Beaupre, Michael, Lin, Xun, Joshi, Preet, Rathi, Sonika, McLaughlin, Patrick A., Kempen, Cody, Mehta, Neil, Eskiocak, Onur, Yueh, Brian, Blumberg, Richard S., van der Velden, Adrianus W. M., Shroyer, Kenneth R., Bialkowska, Agnieszka B., Beyaz, Semir, Kumar, Pawan

“…Interleukin-22 (IL-22) signaling in the intestines is critical for promoting tissue-protective functions. However, since a diverse array of cell types…”
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Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection by Bettke, Julie A, Tam, Jason W, Montoya, Valeria, Butler, Brian P, van der Velden, Adrianus W M

“…Persistent infections generally involve a complex balance between protective immunity and immunopathology. We used a murine model to investigate the role of…”
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CCR2 + Inflammatory Monocytes Are Recruited to Yersinia pseudotuberculosis Pyogranulomas and Dictate Adaptive Responses at the Expense of Innate Immunity during Oral Infection by Zhang, Yue, Khairallah, Camille, Sheridan, Brian S, van der Velden, Adrianus W M, Bliska, James B

“…Murine Ly6C inflammatory monocytes (IMs) require CCR2 to leave the bone marrow and enter mesenteric lymph nodes (MLNs) and other organs in response to…”
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Mechanism-Based Probe for the Analysis of Cathepsin Cysteine Proteases in Living Cells by Hang, Howard C, Loureiro, Joana, Spooner, Eric, van der Velden, Adrianus W. M, Kim, You-Me, Pollington, Annette M, Maehr, Rene, Starnbach, Michael N, Ploegh, Hidde L

“…Mechanism-based probes are providing new tools to evaluate the enzymatic activities of protein families in complex mixtures and to assign protein function. The…”
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Down-Modulation of TCR Expression by Salmonella enterica serovar Typhimurium by van der Velden, Adrianus W. M, Dougherty, Jeffrey T, Starnbach, Michael N

“…T cell-mediated adaptive immunity is required to help clear infection with the facultative intracellular bacterial pathogen Salmonella enterica serovar…”
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A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells by Khairallah, Camille, Bettke, Julie A., Gorbatsevych, Oleksandr, Qiu, Zhijuan, Zhang, Yue, Cho, Kyungjin, Kim, Kwang Soon, Chu, Timothy H., Imperato, Jessica N., Hatano, Shinya, Romanov, Galina, Yoshikai, Yasunobo, Puddington, Lynn, Surh, Charles D., Bliska, James B., van der Velden, Adrianus W. M., Sheridan, Brian S.

“…Although murine γδ T cells are largely considered innate immune cells, they have recently been reported to form long-lived memory populations. Much remains…”
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Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells by von Andrian, Ulrich H, Cavanagh, Lois L, Bonasio, Roberto, Mazo, Irina B, Halin, Cornelia, Cheng, Guiying, van der Velden, Adrianus W M, Cariappa, Annaiah, Chase, Catherine, Russell, Paul, Starnbach, Michael N, Koni, Pandelakis A, Pillai, Shiv, Weninger, Wolfgang

“…Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the…”
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Contribution of Asparagine Catabolism to Salmonella Virulence by McLaughlin, Patrick A, McClelland, Michael, Yang, Hee-Jeong, Porwollik, Steffen, Bogomolnaya, Lydia, Chen, Juei-Suei, Andrews-Polymenis, Helene, van der Velden, Adrianus W M

“…Salmonellae are pathogenic bacteria that cause significant morbidity and mortality in humans worldwide. Salmonellae establish infection and avoid clearance by…”
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Mutant p53 suppresses innate immune signaling to promote tumorigenesis by Ghosh, Monisankar, Saha, Suchandrima, Bettke, Julie, Nagar, Rachana, Parrales, Alejandro, Iwakuma, Tomoo, van der Velden, Adrianus W.M., Martinez, Luis A.

“…Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function activities. We report a mechanism by which mtp53 suppresses both cell-autonomous and…”
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CCR2+ Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8+ T Cell Response to the Protective YopE69-77 Epitope during Yersinia Infection by Zhang, Yue, Tam, Jason W, Mena, Patricio, van der Velden, Adrianus W M, Bliska, James B

“…During Yersinia pseudotuberculosis infection of C57BL/6 mice, an exceptionally large CD8+ T cell response to a protective epitope in the type III secretion…”
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Persistent salmonellosis causes pancreatitis in a murine model of infection by DelGiorno, Kathleen E, Tam, Jason W, Hall, Jason C, Thotakura, Gangadaar, Crawford, Howard C, van der Velden, Adrianus W M

“…Pancreatitis, a known risk factor for the development of pancreatic ductal adenocarcinoma, is a serious, widespread medical condition usually caused by alcohol…”
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Salmonella Rapidly Kill Dendritic Cells via a Caspase-1- Dependent Mechanism by van der Velden, Adrianus W. M, Velasquez, Marisela, Starnbach, Michael N

“…Dendritic cells provide a critical link between innate and acquired immunity. In this study, we demonstrate that the bacterial pathogen Salmonella enterica…”
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CD11b+ Ly6Chi Ly6G- immature myeloid cells recruited in response to Salmonella enterica serovar Typhimurium infection exhibit protective and immunosuppressive properties by Tam, Jason W, Kullas, Amy L, Mena, Patricio, Bliska, James B, van der Velden, Adrianus W M

“…Immature myeloid cells in bone marrow are a heterogeneous population of cells that, under normal conditions, provide tissues with protective cell types such as…”
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Visible Fluorescence Detection of Type III Protein Secretion from Bacterial Pathogens by Yount, Jacob S, Tsou, Lun K, Dossa, Paul D, Kullas, Amy L, van der Velden, Adrianus W. M, Hang, Howard C

“…Type III protein secretion is essential for many Gram-negative bacterial infections of host cells and an attractive target for new antibacterial drugs. Here,…”
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Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer by Sivaram, Nithya, McLaughlin, Patrick A, Han, Han V, Petrenko, Oleksi, Jiang, Ya-Ping, Ballou, Lisa M, Pham, Kien, Liu, Chen, van der Velden, Adrianus W.M, Lin, Richard Z

“…The presence of tumor-infiltrating T cells is associated with favorable patient outcomes, yet most pancreatic cancers are immunologically silent and resistant…”
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Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation‐induced T cell metabolic reprogramming by Torres, AnnMarie, Luke, Joanna D., Kullas, Amy L., Kapilashrami, Kanishk, Botbol, Yair, Koller, Antonius, Tonge, Peter J., Chen, Emily I., Macian, Fernando, Velden, Adrianus W. M.

“…Asparagine deprivation causes inhibition of T cell activation characterized by the suppression of mTOR signaling, autophagy, Myc expression, and lactate…”
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