Search Results - "van der Valk, E J M"

Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation by Hessel, M. H. M., Atsma, D. E., van der Valk, E. J. M., Bax, W. H., Schalij, M. J., van der Laarse, A.

“…Elevated cardiac troponin-I (cTnI) levels have been demonstrated in serum of patients without acute coronary syndromes, potentially via a stretch-related…”
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Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent by Umar, S, van der Valk, E. J. M, Schalij, M. J, van der Wall, E. E, Atsma, D. E, van der Laarse, A

“…Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin…”
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Release kinetics of intact and degraded troponin I and T after irreversible cell damage by Hessel, M.H.M., Michielsen, E.C.H.J., Atsma, D.E., Schalij, M.J., van der Valk, E.J.M., Bax, W.H., Hermens, W.T., van Dieijen-Visser, M.P., van der Laarse, A.

“…We characterized the release kinetics of cardiac troponin I and T in relation to lactate dehydrogenase (LDH) from cardiomyocytes before and after the…”
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Integrin stimulation induces calcium signalling in rat cardiomyocytes by a NO-dependent mechanism by van der Wees, C G C, Bax, W H, van der Valk, E J M, van der Laarse, A

“…The myocardial stretch-induced increase in intracellular [Ca(2+)] ([Ca(2+)](i)) is considered to be caused by integrin stimulation. Myocardial stretch is also…”
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Protection of myocytes against free radical-induced damage by accelerated turnover of the glutathione redox cycle by Le, C T, Hollaar, L, Van der Valk, E J, Franken, N A, Van Ravels, F J, Wondergem, J, Van der Laarse, A

“…The primary defence mechanism of myocytes against peroxides and peroxide-derived peroxyl and alkoxyl radicals is the glutathione redox cycle. The purpose of…”
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Effects of glucose, Trolox-C, and glutathione disulphide on lipid peroxidation and cell death induced by oxidant stress in rat heart by Le, C T, Hollaar, L, van der Valk, E J, van der Laarse, A

“…The aim was to find effective protection of myocytes against peroxide induced damage in terms of preservation of contractile activity, protection against lipid…”
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Oxidative stress-induced perturbations of calcium homeostasis and cell death in cultured myocytes: role of extracellular calcium by Persoon-Rothert, M, Egas-Kenniphaas, J M, van der Valk-Kokshoorn, E J, Buys, J P, van der Laarse, A

“…The role of extracellular calcium in the process of oxidative stress-induced calcium overload and cell death was investigated in cultured neonatal rat…”
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A method to quantitate cell numbers of muscle cells and non-muscle cells in homogenised heart cell cultures by van der Laarse, A, Hollaar, L, van der Valk, E J, Hamers, S

“…Neonatal rat heart cell cultures are popular research models in cardiovascular investigations. A major disadvantage is the variable contribution of non-muscle…”
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Cumene hydroperoxide induced changes in calcium homeostasis in cultured neonatal rat heart cells by Persoon-Rothert, M, Egas-Kenniphaas, J M, van der Valk-Kokshoorn, E J, van der Laarse, A

“…The relationship between oxidative stress induced cell necrosis and perturbation of intracellular calcium homeostasis was investigated in cultured myocytes…”
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Buthionine sulfoximine reduces the protective capacity of myocytes to withstand peroxide-derived free radical attack by Le, C T, Hollaar, L, van der Valk, E J, van der Laarse, A

“…Mammalian heart myocytes have a limited capacity to withstand the deleterious effects of free radical generating compounds. To assess the role of the…”
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Isoproterenol-induced cytotoxicity in neonatal rat heart cell cultures is mediated by free radical formation by Persoon-Rothert, M, van der Valk-Kokshoorn, E J, Egas-Kenniphaas, J M, Mauve, I, van der Laarse, A

“…The cardiotoxic effect of the beta-adrenergic agonist isoproterenol was studied in cultured neonatal rat myocytes. A progressive increase in irreversible cell…”
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Prevention of cumene hydroperoxide induced oxidative stress in cultured neonatal rat myocytes by scavengers and enzyme inhibitors by Persoon-Rothert, M, Egas-Kenniphaas, J M, van der Valk-Kokshoorn, E J, Mauve, I, van der Laarse, A

“…Oxidative stress induced by cumene hydroperoxide was studied in cultured neonatal rat myocytes. A progressive increase of irreversible cell injury as…”
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