Search Results - "van der Schoot, Ellen C"
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Predicting anti-RhD titers in donors: Boostering response and decline rates are personal
Published in PloS one (26-04-2018)“…Anti-RhD immunised donors provide anti-RhD immunoglobulins used for the prevention of rhesus disease. These donors are periodically hyper-immunised (boostered)…”
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Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
Published in Nature communications (05-10-2021)“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs)…”
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Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals
Published in Scientific reports (17-09-2021)“…Beta-hemoglobinopathies become prominent after birth due to a switch from γ-globin to the mutated β-globin. Haploinsufficiency for the erythroid specific…”
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Anti-glycoprotein Ibα autoantibodies do not impair circulating thrombopoietin levels in immune thrombocytopenia patients
Published in Haematologica (Roma) (01-04-2020)Get full text
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Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight
Published in Haematologica (Roma) (01-10-2020)“…Whole blood donors, especially frequently donating donors, have a risk of iron deficiency and low hemoglobin levels, which may affect their health and…”
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Patients with IgG1-anti-red blood cell autoantibodies show aberrant Fc-glycosylation
Published in Scientific reports (15-08-2017)“…Autoimmune hemolytic anemia (AIHA) is a potentially severe disease in which red blood cells (RBC) are destroyed by IgG anti-RBC autoantibodies which can lead…”
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Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
Published in Frontiers in immunology (28-02-2022)“…Many studies already reported on the association between patient characteristics on the severity of COVID-19 disease outcome, but the relation with SARS-CoV-2…”
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HIP (HPA-screening in pregnancy) study: protocol of a nationwide, prospective and observational study to assess incidence and natural history of fetal/neonatal alloimmune thrombocytopenia and identifying pregnancies at risk
Published in BMJ open (20-07-2020)“…IntroductionFetal and neonatal alloimmune thrombocytopenia (FNAIT) may lead to severe fetal or neonatal bleeding and/or perinatal death. Maternal…”
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A functional spleen contributes to afucosylated IgG in humans
Published in Scientific reports (15-12-2021)“…As a lymphoid organ, the spleen hosts a wide range of immune cell populations, which not only remove blood-borne antigens, but also generate and regulate…”
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Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study
Published in International journal of molecular sciences (01-07-2021)“…Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that causes thrombocytopenia and a risk of bleeding in the (unborn) child that result from…”
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IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice
Published in Frontiers in immunology (16-07-2020)“…It has long been appreciated that immunoglobulins are not just the effector endpoint of humoral immunity, but rather have a complex role in regulating antibody…”
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Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity
Published in Trends in immunology (01-10-2022)“…Healthy immune responses require efficient protection without excessive inflammation. Recent discoveries on the degree of fucosylation of a human N-linked…”
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Antibodies against Platelet Glycoproteins in Clinically Suspected VITT Patients
Published in Antibodies (Basel) (01-05-2024)“…Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but severe complication following COVID-19 vaccination, marked by thrombocytopenia and thrombosis…”
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Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region
Published in Proceedings of the National Academy of Sciences - PNAS (20-02-2018)“…A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually…”
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Molecular typing of human platelet and neutrophil antigens (HPA and HNA)
Published in Transfusion and apheresis science (01-04-2014)“…Abstract Genotyping is an important tool in the diagnosis of disorders involving allo-immunisation to antigens present on the membranes of platelets and…”
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Genotyping to prevent Rh disease: has the time come?
Published in Current opinion in hematology (01-11-2017)“…In this review, we analyzed the current literature on noninvasive fetal RHD typing to answer the question whether the administration of RhIg to prevent…”
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Monoclonal RhD prophylaxis: high time to evaluate efficacy
Published in The Lancet (British edition) (02-03-2024)“…If left untreated, HDFN can result in severe anaemia, jaundice, and even severe brain damage (ie, kernicterus) and death. Since the 1960s, screening for the…”
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A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy
Published in Blood (23-01-2014)“…Immunoglobulin G (IgG) formed during pregnancy against human platelet antigens (HPAs) of the fetus mediates fetal or neonatal alloimmune thrombocytopenia…”
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Sensitivity of fetal RHD screening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands
Published in BMJ (Online) (07-11-2016)“…Objective To determine the accuracy of non-invasive fetal testing for the RHD gene in week 27 of pregnancy as part of an antenatal screening programme to…”
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