Search Results - "van der Schans, G P"

Standard Operating Procedure for Immunuslotblot Assay for Analysis of DNA/Sulfur Mustard Adducts in Human Blood and Skin by van der Schans, G.P., Mars-Groenendijk, R., de Jong, L.P.A., Benschop, H.P., Noort, D.

“…A standard operating procedure has been developed for an immunoslotblot assay of sulfur mustard adducts to DNA in human blood and skin for use in a field…”
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(Pheo)Melanin Photosensitizes UVA-Induced DNA Damage in Cultured Human Melanocytes by WENCZL, E, VAN DER SCHANS, G. P, ROZA, L, KOLB, R. M, TIMMERMAN, A. J, SMIT, N. P. M, PAVEL, S, SCHOTHORST, A. A

“…The question of whether melanins are photoprotecting and/or photosensitizing in human skin cells continues to be debated. To evaluate the role of melanin upon…”
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Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines by EIJDEMS, E. W. H. M, DE HAAS, M, TIMMERMAN, A. J, VAN DER SCHANS, G. P, KAMST, E, DE NOOIJ, J, ASTALDI RICOTTI, G. C. B, BORST, P, BAAS, F

“…Multidrug-resistant (MDR) cell lines often have a compound phenotype, combining reduced drug accumulation with a decrease in topoisomerase II. We have analysed…”
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Immunochemical detection of DNA damage induction and repair at different cellular stages of spermatogenesis of the hamster after in vitro or in vivo exposure to ionizing radiation by Van Loon, A A, Den Boer, P J, Van der Schans, G P, Mackenbach, P, Grootegoed, J A, Baan, R A, Lohman, P H

“…An immunochemical method has been used to detect quantitatively DNA damage caused by ionizing radiation in germ cells. With this method, DNA strand breaks as…”
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Verification of Exposure to Sulfur Mustard in Two Casualties of the Iran-Iraq Conflict by Benschop, Hendrik P., van der Schans, Govert P., Noort, Daan, Fidder, Alex, Mars-Groenendijk, Roos H., de Jong, Leo P.A.

“…The exposure of two Iranian victims of the Iran-Iraq conflict (1980–1988) to sulfur mustard was established by immunochemical and mass spectrometric analysis…”
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Synthesis, Characterization, and Quantitation of the Major Adducts Formed between Sulfur Mustard and DNA of Calf Thymus and Human Blood by Fidder, Alex, Moes, Gerrit W. H, Scheffer, Annehieke G, van der Schans, Govert P, Baan, Robert A, de Jong, Leo P. A, Benschop, Hendrik P

“…As part of a program to develop methods for verification of alleged exposure to sulfur mustard, we synthesized and characterized the adducts most likely formed…”
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Effect of glutathione depletion on the cytotoxicity of xenobiotics and induction of single-strand DNA breaks by ionizing radiation in isolated hamster round spermatids by Den Boer, P J, van Loon, A A, Mackenbach, P, van der Schans, G P, Grootegoed, J A

“…The role of glutathione (GSH) in cellular protection mechanisms in round spermatids from hamsters was studied. Isolated spermatids were largely depleted of GSH…”
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A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges by Zdzienicka, M Z, van der Schans, G P, Natarajan, A T, Thompson, L H, Neuteboom, I, Simons, J W

“…We have isolated a Chinese hamster ovary cell mutant hypersensitive to monofunctional alkylating agents. The mutant, designed as EM-C11, showed…”
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Detection of base damage in DNA in human blood exposed to ionizing radiation at biologically relevant doses by van Loon, A A, Groenendijk, R H, van der Schans, G P, Lohman, P H, Baan, R A

“…The alkaline elution technique for the detection of DNA damage has been adapted to allow application on unlabelled blood cells. Both the induction and…”
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A Fourth Complementation Group among Ionizing Radiation-Sensitive Chinese Hamster Cell Mutants Defective in DNA Double-Strand Break Repair by Zdzienicka, M. Z., van Wessel, N., van der Schans, G. P.

“…The XR-V9B mutant of Chinese hamster V79 cells which exhibits hypersensitivity to ionizing radiation was isolated by the replica plating technique. The…”
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An immunochemical assay to detect DNA damage in bovine sperm by van der Schans, G. P, Haring, R, van Dijk-Knijnenburg, H. C, Bruijnzeel, P. L, den Daas, N. H

“…An immunochemical assay has been developedto detect oxidative damage in bovine sperm DNA. Sperm DNA contains a large amount of oxidative damage as a result of…”
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Ataxia-telangiectasia-like chinese hamster V79 cell mutants with radioresistant DNA synthesis, chromosomal instability, and normal DNA strand break repair by ZDZIENICKA, M. Z, JASPERS, N. G. J, VAN DER SCHANS, G. P, NATARAJAN, A. T, SIMONS, J. W. I. M

“…We have isolated three radiosensitive mutants (V-C4, V-E5, and V-G8) of the Chinese hamster V79 cell line which also show increased sensitivities to killing by…”
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Induction and repair of DNA single-strand breaks and DNA base damage at different cellular stages of spermatogenesis of the hamster upon in vitro exposure to ionizing radiation by van Loon, A A, Sonneveld, E, Hoogerbrugge, J, van der Schans, G P, Grootegoed, J A, Lohman, P H, Baan, R A

“…Alkaline elution has been used for quantitative detection of DNA damage caused by ionizing radiation in unlabeled somatic and germ cells. Both the induction…”
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Different repair kinetics of radiation-induced DNA lesions in human and murine white blood cells by van Loon, A A, Timmerman, A J, van der Schans, G P, Lohman, P H, Baan, R A

“…Exposure of cells to ionizing radiation gives rise to DNA damage, comprising strand breaks and base modifications. All these lesions may contribute to cell…”
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Detection of DNA damage in cells exposed to ionizing radiation by use of anti-single-stranded DNA monoclonal antibody by van der Schans, G P, van Loon, A A, Groenendijk, R H, Baan, R A

“…An immunochemical method has been developed for quantitative detection of DNA damage in mammalian cells. The method is based on the binding of a monoclonal…”
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DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays by Van der Schans, G P, Paterson, M C, Cross, W G

“…The production and rejoining of DNA single-strand and double-strand breaks have been monitored in monolayer cultures of proliferating human skin fibroblasts by…”
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Mutagenic response and repair of cis-DDP-induced DNA cross-links in the Chinese hamster V79 cell mutant V-H4 which is homologous to Fanconi anemia (group A) by Studzian, K, Telleman, P, van der Schans, G P, Zdzienicka, M Z

“…Previously, it has been shown that the V-H4 mutant of Chinese hamster V79 cells is homologous to Fanconi anemia (FA) group A cells. This hamster cell mutant…”
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Detection of single-strand breaks and base damage in DNA of blood cells from leukaemia patients receiving chemo- and radiotherapy by van Loon, A A, Raadsheer, F C, Timmerman, A J, Haanen, C, Wessels, J, van der Schans, G P, Lohmans, P H, Baan, R A

“…Chemotherapy combined with total-body irradiation (TBI), a conditioning regimen for bone-marrow transplantation (BMT), causes lesions in the cellular DNA of…”
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Reduction of intracellular glutathione content and radiosensitivity by Vos, O, van der Schans, G P, Roos-Verheij, W S

“…The intracellular glutathione (GSH) content of HeLa, CHO and V79 cells was reduced by incubating the cells in growth medium containing buthionine sulphoximine…”
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Quantitative detection of DNA damage in cells after exposure to ionizing radiation by means of an improved immunochemical assay by van Loon, A A, Groenendijk, R H, Timmerman, A J, van der Schans, G P, Lohman, P H, Baan, R A

“…A simple, sensitive and fast immunochemical method has been developed to quantify the amount of DNA damage in cells of human blood after in vitro exposure to…”
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