Search Results - "van der Schans, Edwin J. C."

The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein by Prahl, Jordan D, Pierce, Steven E, van der Schans, Edwin J C, Coetzee, Gerhard A, Tyson, Trevor

“…One of the most significant risk variants for Parkinson's disease (PD), rs356182, is located at the PD-associated locus near the alpha-synuclein (α-syn)…”
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Post-GWAS knowledge gap: the how, where, and when by Pierce, Steven E., Booms, Alix, Prahl, Jordan, van der Schans, Edwin J. C., Tyson, Trevor, Coetzee, Gerhard A.

“…Genetic risk for complex diseases very rarely reflects only Mendelian-inherited phenotypes where single-gene mutations can be followed in families by linkage…”
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Dimerization of the Klenow Fragment of Escherichia coli DNA Polymerase I Is Linked to Its Mode of DNA Binding by Bailey, Michael F, Van der Schans, Edwin J. C, Millar, David P

“…Upon associating with a proofreading polymerase, the nascent 3‘ end of a DNA primer/template has two possible fates. Depending upon its suitability as a…”
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Parkinson’s disease risk enhancers in microglia by Booms, Alix, Pierce, Steven E., van der Schans, Edwin J.C., Coetzee, Gerhard A.

“…Genome-wide association studies have identified thousands of single nucleotide polymorphisms that associate with increased risk for Parkinson’s disease (PD),…”
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Determinants of DNA Mismatch Recognition within the Polymerase Domain of the Klenow Fragment by Thompson, Elizabeth H. Z, Bailey, Michael F, van der Schans, Edwin J. C, Joyce, Catherine M, Millar, David P

“…The Klenow fragment of Escherichia coli DNA polymerase I catalyzes template-directed synthesis of DNA and uses a separate 3‘−5‘ exonuclease activity to edit…”
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Interaction of DNA Polymerase I (Klenow Fragment) with DNA Substrates Containing Extrahelical Bases:  Implications for Proofreading of Frameshift Errors during DNA Synthesis by Lam, Wai-Chung, Van der Schans, Edwin J. C, Sowers, Lawrence C, Millar, David P

“…Frameshift mutagenesis occurs through the misalignment of primer and template strands during DNA synthesis and involves DNA intermediates that contain one or…”
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Effects of Mutations on the Partitioning of DNA Substrates between the Polymerase and 3‘−5‘ Exonuclease Sites of DNA Polymerase I (Klenow Fragment) by Lam, Wai-Chung, Van der Schans, Edwin J. C, Joyce, Catherine M, Millar, David P

“…Site-directed mutagenesis and time-resolved fluorescence spectroscopy were used to evaluate the contributions of individual amino acid side chains to the…”
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Thermodynamic Dissection of the Polymerizing and Editing Modes of a DNA Polymerase by Bailey, Michael F., van der Schans, Edwin J.C., Millar, David P.

“…DNA polymerases with intrinsic proofreading activity interact with DNA primer/templates in two distinct modes, corresponding to the complexes formed during the…”
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