Search Results - "van der Saag, Paul"

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β by Kuiper, George G. J. M, Lemmen, Josephine G, Carlsson, Bo, Corton, J. Christopher, Safe, Stephen H, van der Saag, Paul T, van der Burg, Bart, Gustafsson, Jan-Åke

“…The rat, mouse and human estrogen receptor (ER) exists as two subtypes, ERα and ERβ, which differ in the C-terminal ligand-binding domain and in the N-terminal…”
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Ataxia with loss of Purkinje cells in a mouse model for Refsum disease by Ferdinandusse, Sacha, Zomer, Anna W.M, Komen, Jasper C, van den Brink, Christina E, Thanos, Melissa, Hamers, Frank P.T, Wanders, Ronald J.A, van der Saag, Paul T, Poll-The, Bwee Tien, Brites, Pedro

“…Refsum disease is caused by a deficiency of phytanoyl-CoA hydroxylase (PHYH), the first enzyme of the peroxisomal α-oxidation system, resulting in the…”
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The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor by van der Woude, Hester, ter Veld, Marcel G. R., Jacobs, Natasja, van der Saag, Paul T., Murk, Albertinka J., Rietjens, Ivonne M. C. M.

“…Quercetin causes biphasic modulation of the proliferation of specific colon and mammary cancer cells. In this study, the possible involvement of the estrogen…”
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Toward More Useful In Vitro Toxicity Data with Measured Free Concentrations by Heringa, Minne B, Schreurs, Richard H. M. M, Busser, Frans, Van Der Saag, Paul T, Van Der Burg, Bart, Hermens, Joop L. M

“…In vitro assays and computer models are promising alternatives for in vivo animal testing, but the power of these alternative methods to predict in vivo risk…”
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Specific Recognition of Apoptotic Cells Reveals a Ubiquitous and Unconventional Innate Immunity by Cvetanovic, Marija, Mitchell, Justin E., Patel, Vimal, Avner, Benjamin S., Su, Yan, van der Saag, Paul T., Witte, Pamela L., Fiore, Stefano, Levine, Jerrold S., Ucker, David S.

“…The purpose of physiological cell death is the noninflammatory clearance of cells that have become inappropriate or nonfunctional. Consistent with this…”
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Expression profiles and functional implications of p53‐like transcription factors in thymic epithelial cell subtypes by Kikuchi, Tomoki, Ichimiya, Shingo, Kojima, Takashi, Crisa, Laura, Koshiba, Shigeru, Tonooka, Akiko, Kondo, Nobuhiko, van der Saag, Paul T., Yokoyama, Shigeaki, Sato, Noriyuki

“…In this study, we investigated the localization and functional significance of p53 tumor suppressor‐like molecules, p63 and p73, in human thymic epithelial…”
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In Vivo Imaging of Activated Estrogen Receptors in Utero by Estrogens and Bisphenol A by Lemmen, Josephine G., Arends, Roel J., van der Saag, Paul T., van der Burg, Bart

“…Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic…”
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In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue by Engdahl, Cecilia, Jochems, Caroline, Gustafsson, Jan-Åke, van der Saag, Paul T, Carlsten, Hans, Lagerquist, Marie K

“…Raloxifene is a selective oestrogen receptor modulator with tissue-specific effects. The mechanisms behind the effects of raloxifene are partly unclear, and…”
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Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice by ter Veld, Marcel G.R., Zawadzka, E., van den Berg, J.H.J., van der Saag, Paul T., Rietjens, Ivonne M.C.M., Murk, Albertinka J.

“…The present paper aims at clarifying to what extent seven food-associated compounds, shown before to be estrogenic in vitro, can induce estrogenic effects in…”
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Diet-Derived Polyphenol Metabolite Enterolactone Is a Tissue-Specific Estrogen Receptor Activator by Penttinen, Pauliina, Jaehrling, Jan, Damdimopoulos, Anastasios E, Inzunza, José, Lemmen, Josephine G, van der Saag, Paul, Pettersson, Katarina, Gauglitz, Günter, Mäkelä, Sari, Pongratz, Ingemar

“…Numerous dietary compounds can modify gene expression by binding to the members of the nuclear receptor superfamily of transcription factors. For example,…”
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Estrogenic Potency of Food-Packaging-Associated Plasticizers and Antioxidants As Detected in ERα and ERβ Reporter Gene Cell Lines by ter Veld, Marcel G. R, Schouten, Bastiaan, Louisse, Jochem, van Es, Daan S, van der Saag, Paul T, Rietjens, Ivonne M. C. M, Murk, Albertinka J

“…This study presents the estrogenic potency of 21 food-packaging-associated compounds determined for the first time, using two transfected U2-OS (human…”
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Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice by Penttinen-Damdimopoulou, Pauliina E, Power, Krista A, Hurmerinta, Teija T, Nurmi, Tarja, van der Saag, Paul T, Mäkelä, Sari I

“…Dietary phytoestrogens, such as the lignan metabolite enterolactone (ENL) and the isoflavone genistein (GEN), are suggested to modulate the risk of…”
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Cell scattering of SK-N-MC neuroepithelioma cells in response to ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation by VAN PUIJENBROEK, A. A, VAN WEERING, D. H. J, VAN DEN BRINK, C. E, BOS, J. L, VAN DER SAAG, P. T, DE LAAT, S. W, DEN HERTOG, J

“…The c-ret proto-oncogene encodes a receptor tyrosine kinase which plays an important role in kidney and enteric nervous system development. Germline mutations…”
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Expression of a mutant retinoic acid receptor beta alters lineage differentiation in mouse embryonic stem cells by Chatzi, Christina, van den Brink, Christina E, van der Saag, Paul T, McCaig, Colin D, Shen, Sanbing

“…We have introduced 1 to 2 copies of a deletion mutant (betaDeltaC) of the human retinoic acid receptor beta into mouse embryonic stem (ES) cells. The…”
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Estrogen Receptor (ER)-Mediated Transcriptional Regulation of the Human Corticotropin-Releasing Hormone-Binding Protein Promoter: Differential Effects of ERα and ERβ by van de Stolpe, Anja, Slycke, Annika J, Reinders, Marjolein O, Zomer, Anna W. M, Goodenough, Sharon, Behl, Christian, Seasholtz, Audrey F, van der Saag, Paul T

“…CRH-binding protein (CRH-BP) regulates activation of the hypothalamic-pituitary-adrenal (HPA) axis by binding and inhibiting CRH. We investigated for the first…”
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The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms by Maden, M, Sonneveld, E, van der Saag, P T, Gale, E

“…The aim of these experiments was to determine the endogenous distribution of retinoic acid (RA) across a wide range of embryonic stages in the chick embryo. By…”
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A Novel in Vivo Bioassay for (Xeno-)estrogens Using Transgenic Zebrafish by Legler, Juliette, Broekhof, José L. M, Brouwer, Abraham, Lanser, Peter H, Murk, Albertinka J, van der Saag, Paul T, Vethaak, A. Dick, Wester, Piet, Zivkovic, Danica, van der Burg, Bart

“…Adverse trends in the reproductive health of male fish, including testis abnormalities and intersex gonads, have been increasingly reported over recent years…”
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Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha by Zomer, A W, van Der Burg, B, Jansen, G A, Wanders, R J, Poll-The, B T, van Der Saag, P T

“…Phytanic acid and pristanic acid are branched-chain fatty acids, present at micromolar concentrations in the plasma of healthy individuals. Here we show that…”
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Examination of the in vitro (anti)estrogenic, (anti)androgenic and (anti)dioxin-like activities of tetralin, indane and isochroman derivatives using receptor-specific bioassays by Schreurs, Richard H.M.M., Sonneveld, Edwin, van der Saag, Paul T., van der Burg, Bart, Seinen, Willem

“…Molecules derived from tetralin, indane and isochroman are often used in the synthesis of fragrance materials. The two polycyclic musk fragrances AHTN…”
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Regulation of the Rat Serotonin-1A Receptor Gene by Corticosteroids by Wissink, Sacha, Meijer, Onno, Pearce, David, van der Burg, Bart, van der Saag, Paul T.

“…Dysregulation of the serotonergic system and abnormalities of the hypothalamic-pituitary-adrenal axis function have been implicated to be involved in…”
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