Search Results - "van der Poll, T"

The impact of diabetes on the pathogenesis of sepsis by Koh, G. C. K. W., Peacock, S. J., van der Poll, T., Wiersinga, W. J.

“…Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is…”
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Endothelial barrier dysfunction in septic shock by Opal, S. M., Poll, T.

“…The endothelium provides an essential and selective membrane barrier that regulates the movement of water, solutes, gases, macromolecules and the cellular…”
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Thrombin contributes to protective immunity in pneumonia‐derived sepsis via fibrin polymerization and platelet–neutrophil interactions by Claushuis, T. A. M., Stoppelaar, S. F., Stroo, I., Roelofs, J. J. T. H., Ottenhoff, R., Poll, T., Veer, C.

“…Essentials Immunity and coagulation are linked during sepsis but the role of thrombin is not fully elucidated. We investigated the effect of thrombin…”
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New insights into pathways that determine the link between infection and thrombosis by LEVI, M, DER POLL, T. Van, SCHULTZ, M

“…Severe infection is often linked to prothrombotic events. Indeed, haemostatic abnormalities are encountered in most cases of infection, ranging from an…”
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The Vagus Nerve and Nicotinic Receptors Modulate Experimental Pancreatitis Severity in Mice by van Westerloo, David J., Giebelen, Ilona A., Florquin, Sandrine, Bruno, Marco J., LaRosa, Gregory J., Ulloa, Luis, Tracey, Kevin J., van der Poll, T.

“…Background & Aims: The nervous system, through the vagus nerve, controls inflammation by decreasing the release of tumor necrosis factor-α from endotoxin…”
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The influence of corticosteroids on hemostasis in healthy subjects by Majoor, C. J., Sneeboer, M. M. S., Kievit, A., Meijers, J. C. M., Poll, T., Lutter, R., Bel, E. H., Kamphuisen, P. W.

“…Essentials Corticosteroids are associated with venous thromboembolism in patients with inflammatory diseases. Healthy subjects received 0.5 mg kg−1 of…”
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mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin by Ramirez-Moral, I., Yu, X., Butler, J. M., van Weeghel, M., Otto, N. A., Ferreira, B. Lima, Maele, L. Van, Sirard, J. C., de Vos, A. F., de Jong, M. D., Houtkooper, R. H., van der Poll, T.

“…Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective…”
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Rage signalling promotes intestinal tumourigenesis by Heijmans, J, Büller, N V J A, Hoff, E, Dihal, A A, van der Poll, T, van Zoelen, M A D, Bierhaus, A, Biemond, I, Hardwick, J C H, Hommes, D W, Muncan, V, van den Brink, G R

“…Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns…”
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Rapid outer-surface protein C DNA tattoo vaccination protects against Borrelia afzelii infection by Wagemakers, A, Mason, L M K, Oei, A, de Wever, B, van der Poll, T, Bins, A D, Hovius, J W R

“…Borrelia afzelii is the predominant Borrelia species causing Lyme borreliosis in Europe. Currently there is no human vaccine against Lyme borreliosis, and most…”
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Coagulation and inflammation in scrub typhus and murine typhus—a prospective comparative study from Laos by Paris, D.H., Chansamouth, V., Nawtaisong, P., Löwenberg, E.C., Phetsouvanh, R., Blacksell, S.D., Lee, S.J., Dondorp, A.M., Newton, P.N., van der Poll, T., Levi, M., Day, N. P.J.

“…Scrub typhus (caused by Orientia tsutsugamushi) and murine typhus (caused by Rickettsia typhi) cause up to 28% of febrile episodes in Thailand and Laos. The…”
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Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans by Stegenga, M. E., Crabben, S. N. van der, Dessing, M. C., Pater, J. M., Van Den Pangaart, P. S., De Vos, A. F., Tanck, M. W., Roos, D., Sauerwein, H. P., Van Der Poll, T.

“…Aims  Type 2 diabetes is frequently associated with infectious complications. Swift activation of leucocytes is important for an adequate immune response. We…”
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Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats by VAN WESTERLOO, D. J., GIEBELEN, I. A. J., MEIJERS, J. C. M., DAALHUISEN, J., DE VOS, A. F., LEVI, M., VAN DER POLL, T.

“…Background: Sepsis and endotoxemia are associated with concurrent activation of inflammation and the hemostatic mechanism, which both contribute to organ…”
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Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis by Bos, L D, Schouten, L R, van Vught, L A, Wiewel, M A, Ong, D S Y, Cremer, O, Artigas, A, Martin-Loeches, I, Hoogendijk, A J, van der Poll, T, Horn, J, Juffermans, N, Calfee, C S, Schultz, M J

“…We hypothesised that patients with acute respiratory distress syndrome (ARDS) can be clustered based on concentrations of plasma biomarkers and that the…”
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Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients by Dickson, Robert P, Schultz, Marcus J, van der Poll, Tom, Schouten, Laura R, Falkowski, Nicole R, Luth, Jenna E, Sjoding, Michael W, Brown, Christopher A, Chanderraj, Rishi, Huffnagle, Gary B, Bos, Lieuwe D J

“…Recent studies have revealed that, in critically ill patients, lung microbiota are altered and correlate with alveolar inflammation. The clinical significance…”
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Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia by Pajkrt, D, Doran, J E, Koster, F, Lerch, P G, Arnet, B, van der Poll, T, ten Cate, J W, van Deventer, S J

“…High-density lipoprotein (HDL) has been found to neutralize LPS activity in vitro and in animals in vivo. We sought to determine the effects of reconstituted…”
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Characteristics of AIDS patients in Dutch intensive care units by Huson, M.A.M, Bakhshi-Raiez, F, Grobusch, M.P, de Jonge, E, de Keizer, N.F, van der Poll, T

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The influence of HIV infection on coagulation activation during sepsis by Huson, M.A.M, Kalkman, R, Alabi, A.S, Beyeme, J.O, Grobusch, M.P, Meijers, J.C.M, van der Poll, T

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The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury by RENCKENS, R., ROELOFS, J. J. T. H., DE WAARD, V., FLORQUIN, S., LIJNEN, H. R., CARMELIET, P., VAN DER POLL, T.

“…Background: The plasma levels of the plasminogen activator‐inhibitor type 1 (PAI‐1) are consistently elevated in patients with sterile tissue injury, often…”
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The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia by LEVI, M., VAN DER POLL, T., TEN CATE, H., VAN DEVENTER, S. J. H.

“…Disseminated intravascular coagulation (DIC) is a frequently occurring complication of sepsis and may contribute to multiple organ failure. More insight into…”
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Non-conventional immunomodulation in the management of sepsis by Slim, M.A., Turgman, O., van Vught, L.A., van der Poll, T., Wiersinga, W.J.

“…Sepsis remains a critical global health issue, demanding novel therapeutic strategies. Traditional immunomodulation treatments such as corticosteroids,…”
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