Search Results - "van der Poll, Derek"

Design, Synthesis, and Biological Evaluation of a Robust, Biodegradable Dendrimer by van der Poll, Derek G, Kieler-Ferguson, Heidi M, Floyd, William C, Guillaudeu, Steven J, Jerger, Katherine, Szoka, Francis C, Fréchet, Jean M

“…PEGylated dendrimers are attractive for biological applications due to their tunable pharmacokinetics and ability to carry multiple copies of bioactive…”
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Synthesis and Properties of Star-Comb Polymers and Their Doxorubicin Conjugates by Chen, Bo, van der Poll, Derek G, Jerger, Katherine, Floyd, William C, Fréchet, Jean M. J, Szoka, Francis C

“…We describe a six-step synthesis to water-soluble doxorubicin (DOX)-loaded biodegradable PEGylated star-comb polymers with favorable pharmaceutical properties…”
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Smaller Building Blocks Form Larger Assemblies:  Aggregation Behavior of Biaryl-Based Dendritic Facial Amphiphiles by Ambade, Ashootosh V, Aathimanikandan, Sivakumar V, van der Poll, Derek, Thayumanavan, S

“…Synthesis and micellar behavior of biaryl-based benzyl ether dendritic molecules prepared from a new biaryl building block are described. The key objective of…”
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Discovery of a Novel Cabazitaxel Nanoparticle–Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β‑Cyclodextrin–PEG Copolymer Based Delivery Platform by Metcalf, Chester A, Svenson, Sonke, Hwang, Jungyeon, Tripathi, Snehlata, Gangal, Geeti, Kabir, Sujan, Lazarus, Douglas, Cole, Roderic, Sweryda-Krawiec, Beata, Shum, Pochi, Brown, Donna, Case, Roy I, van der Poll, Derek, Rohde, Ellen, Harlfinger, Stephanie, Teng, Chi-Hse, Eliasof, Scott

“…Novel nanoparticle–drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were…”
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Abstract 5135: Sustained and controlled in vivo therapeutic levels of drug payloads in tumors using two separate drug combination platforms: Antibody nanoparticle-drug conjugates and multi-drug nanoparticle-drug conjugates, with the potential for improved drug combinability and anticancer effects by Metcalf, Chester A., Poll, Derek van der, Zhao, Liang, Case, Roy I., Lazarus, Doug, Brown, Donna, Halo, Tiffany, Jayaraman, Lata, Peters, Christian, Rohde, Ellen, Eliasof, Scott

“…Abstract Our nanoparticle-drug conjugates (NDCs), created at Cerulean Pharma Inc. by conjugating drug payloads to our novel β-cyclodextrin-PEG (CDP) copolymer,…”
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Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical by Svenson, Sonke, Case, Roy I, Cole, Roderick O, Hwang, Jungyeon, Kabir, Sujan R, Lazarus, Douglas, Lim Soo, Patrick, Ng, Pei-Sze, Peters, Christian, Shum, Pochi, Sweryda-Krawiec, Beata, Tripathi, Snehlata, van der Poll, Derek, Eliasof, Scott

“…Small interfering RNA (siRNA) therapeutics have potential advantages over traditional small molecule drugs such as high specificity and the ability to inhibit…”
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Abstract PR10: Significant improvements in therapeutic index for conjugated payloads using a nanoparticle-drug conjugate (NDC) platform to provide sustained drug release and potentially improved anticancer effects by Metcalf, Chester, Poll, Derek van der, Zhao, Liang, Halo, Tiffany, Lazarus, Doug, Stockmann, Adam, Peters, Christian, Brown, Donna, Case, Roy, Rohde, Ellen, Jayaraman, Lata, Wang, Hongwei, Crowell, Tiffany, Senderowicz, Adrian, Eliasof, Scott

“…Abstract Cerulean Pharma Inc.'s Dynamic Tumor Targeting™ Platform creates nanoparticle-drug conjugates (NDCs) designed to significantly mitigate a payload's…”
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Macromolecules for the Delivery of Cancer Chemotherapeutics by van der Poll, Derek Gregory

“…Chemotherapy is the practice of treating cancer with antineoplastic drugs. In general, these drugs are highly toxic, and in many patients the side effects from…”
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