Search Results - "van der Poel, Marlijn"

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes by van der Poel, Marlijn, Ulas, Thomas, Mizee, Mark R., Hsiao, Cheng-Chih, Miedema, Suzanne S. M., Adelia, Schuurman, Karianne G., Helder, Boy, Tas, Sander W., Schultze, Joachim L., Hamann, Jörg, Huitinga, Inge

“…Here we report the transcriptional profile of human microglia, isolated from normal-appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS)…”
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Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions by Hendrickx, Debbie A E, van Scheppingen, Jackelien, van der Poel, Marlijn, Bossers, Koen, Schuurman, Karianne G, van Eden, Corbert G, Hol, Elly M, Hamann, Jörg, Huitinga, Inge

“…In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites…”
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Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation by van den Bosch, Aletta M. R., van der Poel, Marlijn, Fransen, Nina L., Vincenten, Maria C. J., Bobeldijk, Anneleen M., Jongejan, Aldo, Engelenburg, Hendrik J., Moerland, Perry D., Smolders, Joost, Huitinga, Inge, Hamann, Jörg

“…Microglia nodules (HLA-DR + cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first…”
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Coordinated changes in the expression of Wnt pathway genes following human and rat peripheral nerve injury by van Vliet, Arie C, Lee, Jinhui, van der Poel, Marlijn, Mason, Matthew R J, Noordermeer, Jasprina N, Fradkin, Lee G, Tannemaat, Martijn R, Malessy, Martijn J A, Verhaagen, Joost, De Winter, Fred

“…A human neuroma-in continuity (NIC), formed following a peripheral nerve lesion, impedes functional recovery. The molecular mechanisms that underlie the…”
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Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables by Mizee, Mark R, Miedema, Suzanne S M, van der Poel, Marlijn, Adelia, Schuurman, Karianne G, van Strien, Miriam E, Melief, Jeroen, Smolders, Joost, Hendrickx, Debbie A, Heutinck, Kirstin M, Hamann, Jörg, Huitinga, Inge

“…Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with…”
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Macrophages Do Not Express the Phagocytic Receptor BAI1/ ADGRB1 by Hsiao, Cheng-Chih, van der Poel, Marlijn, van Ham, Tjakko J, Hamann, Jörg

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Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis by Böttcher, Chotima, van der Poel, Marlijn, Fernández-Zapata, Camila, Schlickeiser, Stephan, Leman, Julia K H, Hsiao, Cheng-Chih, Mizee, Mark R, Adelia, Vincenten, Maria C J, Kunkel, Desiree, Huitinga, Inge, Hamann, Jörg, Priller, Josef

“…Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells…”
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Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions by Fransen, Nina L, Hsiao, Cheng-Chih, van der Poel, Marlijn, Engelenburg, Hendrik J, Verdaasdonk, Kim, Vincenten, Maria C J, Remmerswaal, Ester B M, Kuhlmann, Tanja, Mason, Matthew R J, Hamann, Jörg, Smolders, Joost, Huitinga, Inge

“…Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been suggested that in the progressive late phase, inflammatory lesion…”
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IgG Immune Complexes Break Immune Tolerance of Human Microglia by van der Poel, Marlijn, Hoepel, Willianne, Hamann, Jörg, Huitinga, Inge, Dunnen, Jeroen den

“…Microglia are phagocytic cells involved in homeostasis of the brain and are key players in the pathogenesis of multiple sclerosis (MS). A hallmark of MS…”
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