Search Results - "van der Nagel, R."

Micro-CT and Histological Evaluation of an Neural Interface Implanted Within a Blood Vessel by Opie, Nicholas Lachlan, Oxley, Thomas J., van der Nagel, Nicole R., John, Sam E., Vessey, Kirstan, Rind, Gil S., Ronayne, Stephen M., Fletcher, Erica L., May, Clive N., O'Brien, Terence J.

“…Objective: Recently, we reported the development of a stent-mounted electrode array (Stentrode) capable of chronically recording neural signals from within a…”
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Comparison of the IKr blockers moxifloxacin, dofetilide and E‐4031 in five screening models of pro‐arrhythmia reveals lack of specificity of isolated cardiomyocytes by Nalos, L, Varkevisser, R, Jonsson, MKB, Houtman, MJC, Beekman, JD, van der Nagel, R, Thomsen, MB, Duker, G, Sartipy, P, de Boer, TP, Peschar, M, Rook, MB, van Veen, TAB, van der Heyden, MAG, Vos, MA

“…BACKGROUND AND PURPOSE Drug development requires the testing of new chemical entities for adverse effects. For cardiac safety screening, improved assays are…”
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Comparison of the I Kr blockers moxifloxacin, dofetilide and E‐4031 in five screening models of pro‐arrhythmia reveals lack of specificity of isolated cardiomyocytes by Nalos, L, Varkevisser, R, Jonsson, MKB, Houtman, MJC, Beekman, JD, van der Nagel, R, Thomsen, MB, Duker, G, Sartipy, P, de Boer, TP, Peschar, M, Rook, MB, van Veen, TAB, van der Heyden, MAG, Vos, MA

“…BACKGROUND AND PURPOSE Drug development requires the testing of new chemical entities for adverse effects. For cardiac safety screening, improved assays are…”
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Criss-cross by van der Nagel, R., van Dijk, V. F.

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Criss-cross by van der Nagel, R., van Dijk, V. F.

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The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs by Stams, T R G, Bourgonje, V J A, Beekman, H D M, Schoenmakers, M, Nagel, R, Oosterhoff, P, Opstal, J M, Vos, M A

“…Background and Purpose The electromechanical window (EMW), the interval between the end of the T‐wave and the end of the left ventricular pressure (LVP) curve,…”
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Deleterious acute and chronic effects of bradycardic right ventricular apex pacing: consequences for arrhythmic outcome by Stams, T. R. G., Dunnink, A., van Everdingen, W. M., Beekman, H. D. M., van der Nagel, R., Kok, B., Bierhuizen, M. F. A., Cramer, M. J., Meine, M., Vos, M. A.

“…In the chronic complete atrioventricular (AV) block dog (CAVB) model, both bradycardia and altered ventricular activation due to the uncontrolled…”
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Novel Parameters to Improve Quantification of Repolarization Reserve and Arrhythmogenesis Using a Dofetilide Challenge by Stams, T.R.G, Winckels, S.K.G, Oros, A, Varkevisser, R, Oosterhoff, P, van der Nagel, R, Beekman, H.D.M, Vos, M.A

“…Background In the canine complete AV block (AVB) model with bradycardia, inducibility of drug-induced torsades de pointes (TdP) is usually the primary outcome…”
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NF- B activation is required for adaptive cardiac hypertrophy by Zelarayan, L., Renger, A., Noack, C., Zafiriou, M.-P., Gehrke, C., van der Nagel, R., Dietz, R., de Windt, L., Bergmann, M. W.

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Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity by Oxley, Thomas J, Opie, Nicholas L, John, Sam E, Rind, Gil S, Ronayne, Stephen M, Wheeler, Tracey L, Judy, Jack W, McDonald, Alan J, Dornom, Anthony, Lovell, Timothy J H, Steward, Christopher, Garrett, David J, Moffat, Bradford A, Lui, Elaine H, Yassi, Nawaf, Campbell, Bruce C V, Wong, Yan T, Fox, Kate E, Nurse, Ewan S, Bennett, Iwan E, Bauquier, Sébastien H, Liyanage, Kishan A, van der Nagel, Nicole R, Perucca, Piero, Ahnood, Arman, Gill, Katherine P, Yan, Bernard, Churilov, Leonid, French, Christopher R, Desmond, Patricia M, Horne, Malcolm K, Kiers, Lynette, Prawer, Steven, Davis, Stephen M, Burkitt, Anthony N, Mitchell, Peter J, Grayden, David B, May, Clive N, O'Brien, Terence J

“…Cortical activity can be monitored for 6 months or longer from within the brain vasculature using an endovascular stent-electrode array. High-fidelity…”
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P632Beat-to-beat variability in preload unmasks reduced repolarization reserve in anesthetized dogs with chronic atrio-ventricular block: a role for mechano-electrical feedback by Oosterhoff, P, Stams, TRG, Heijdel, A, Dunnink, A, Beekman, HDM, Van Der Nagel, R, Van Rijen, HVM, Van Der Heyden, MAG, Vos, MA

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Enhancing Calstabin Binding to Ryanodine Receptors Improves Cardiac and Skeletal Muscle Function in Heart Failure by Xander H. T. Wehrens, Lehnart, Stephan E., Reiken, Steven, van der Nagel, Roel, Morales, Raymond, Sun, Jie, Cheng, Zhenzhuang, Deng, Shi-Xiang, de Windt, Leon J., Landry, Donald W., Marks, Andrew R., Olson, Eric N.

“…Abnormalities in intracellular calcium release and reuptake are responsible for decreased contractility in heart failure (HF). We have previously shown that…”
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The electromechanical window is no better than QT prolongation to assess risk of T orsade de P ointes in the complete atrioventricular block model in dogs by Stams, T R G, Bourgonje, V J A, Beekman, H D M, Schoenmakers, M, van der Nagel, R, Oosterhoff, P, van Opstal, J M, Vos, M A

“…Background and Purpose The electromechanical window (EMW), the interval between the end of the T‐wave and the end of the left ventricular pressure (LVP) curve,…”
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Anchored cAMP signalling in progression from hypertrophy to heart failure in a rat model of pressure overload by Soni, S., Corradini, E., Van Der Nagel, R., Boulaksil, M., Heck, A. J. R., Scholten, A. J. R., Vos, M. A., Van Veen, T. A. B.

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Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction by Stein, Mèra, van Veen, Toon A.B., Remme, Carol Ann, Boulaksil, Mohamed, Noorman, Maartje, van Stuijvenberg, Leonie, van der Nagel, Roel, Bezzina, Connie R., Hauer, Richard N.W., de Bakker, Jacques M.T., van Rijen, Harold V.M.

“…Aims Reduced excitability and gap junction expression are commonly found in electrically remodelled diseased hearts, but their contribution to slow conduction…”
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Downregulation of Apoptosis-Inducing Factor in Harlequin Mutant Mice Sensitizes the Myocardium to Oxidative Stress–Related Cell Death and Pressure Overload–Induced Decompensation by van Empel, Vanessa P.M, Bertrand, Anne T, van der Nagel, Roel, Kostin, Sawa, Doevendans, Pieter A, Crijns, Harry J, de Wit, Elly, Sluiter, Wim, Ackerman, Susan L, De Windt, Leon J

“…Apoptosis-inducing factor (AIF), or programmed cell death 8 (Pdcd8), is a highly conserved, ubiquitous flavoprotein localized in the mitochondrial…”
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Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog by Dunnink, Albert, van Opstal, Jurren M., Oosterhoff, Peter, Winckels, Stephan K.G., Beekman, Jet D.M., van der Nagel, Roel, Cora Verduyn, S., Vos, Marc A.

“…Introduction A number of predisposing factors have been suggested to be contributing to drug-induced torsade de pointes (TdP) arrhythmias: short-long-short…”
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Testing IKr blockers in five screening models of pro-arrhythmia shows insufficient specificity of isolated cardiomyocytes by Peschar, Maaike, Nalos, L., Varkevisser, R., van Veen, T.A.B., Houtman, M.J.C., Beekman, J.D., van der Nagel, R., Thomsen, M.B., Duker, G., Sartipy, P., de Boer, T.P., van der Heyden, M.A.G., Vos, M.A.

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