Search Results - "van der Meulen, Ida H"

Functional Screen for microRNAs Suppressing Anchorage-Independent Growth in Human Cervical Cancer Cells by Huseinovic, Angelina, Jaspers, Annelieke, van Splunter, Annina P, Sørgård, Hanne, Wilting, Saskia M, Swarts, Dorian R A, van der Meulen, Ida H, van Beusechem, Victor W, de Menezes, Renée X, Steenbergen, Renske D M

“…The progression of anchorage-dependent epithelial cells to anchorage-independent growth represents a critical hallmark of malignant transformation. Using an in…”
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Human Non-Small Cell Lung Cancer-Chicken Embryo Chorioallantoic Membrane Tumor Models for Experimental Cancer Treatments by Li, Jing, Brachtlova, Tereza, van der Meulen-Muileman, Ida H, Kleerebezem, Stijn, Liu, Chang, Li, Peiyu, van Beusechem, Victor W

“…To promote the preclinical development of new treatments for non-small cell lung cancer (NSCLC), we established NSCLC xenograft tumor assays on the…”
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Quantitative Virus-Associated RNA Detection to Monitor Oncolytic Adenovirus Replication by Brachtlova, Tereza, Li, Jing, van der Meulen-Muileman, Ida H, Sluiter, Femke, von Meijenfeldt, Willem, Witte, Isabella, Massaar, Sanne, van den Oever, Ruben, de Vrij, Jeroen, van Beusechem, Victor W

“…Oncolytic adenoviruses are in development as immunotherapeutic agents for solid tumors. Their efficacy is in part dependent on their ability to replicate in…”
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Evaluation of a Novel Oncolytic Adenovirus Silencing SYVN1 by Vermeulen, Christie, Brachtlova, Tereza, Tol, Nikki, van der Meulen-Muileman, Ida H, Hodzic, Jasmina, van de Vrugt, Henri J, van Beusechem, Victor W

“…Oncolytic adenoviruses are promising new anticancer agents. To realize their full anticancer potential, they are being engineered to express therapeutic…”
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Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer by MARTENS-DE KEMP, Sanne R, NAGEL, Remco, STIGTER-VAN WALSUM, Marijke, VAN DER MEULEN, Ida H, VAN BEUSECHEM, Victor W, BRAAKHUIS, Boudewijn J. M, BRAKENHOFF, Ruud H

“…Despite continuous improvement of treatment regimes, the mortality rates for non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma…”
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The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics by Martens-de Kemp, Sanne R, Brink, Arjen, van der Meulen, Ida H, de Menezes, Renée X, Te Beest, Dennis E, Leemans, C René, van Beusechem, Victor W, Braakhuis, Boudewijn J M, Brakenhoff, Ruud H

“…Patients with advanced stage head and neck squamous cell carcinoma (HNSCC) are often treated with cisplatin-containing chemoradiation protocols. Although…”
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High-throughput RNAi screening reveals cancer-selective lethal targets in the RNA spliceosome by Blijlevens, Maxime, van der Meulen-Muileman, Ida H., de Menezes, Renée X., Smit, Egbert F., van Beusechem, Victor W.

“…Novel therapeutic strategies for non-small-cell lung cancer (NSCLC) are urgently needed. RNA splicing, orchestrated by the spliceosome, is deregulated in many…”
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A genome‐wide siRNA screen for regulators of tumor suppressor p53 activity in human non‐small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment by Siebring‐van Olst, Ellen, Blijlevens, Maxime, Menezes, Renee X., Meulen‐Muileman, Ida H., Smit, Egbert F., Beusechem, Victor W.

“…Reinstating wild‐type tumor suppressor p53 activity could be a valuable option for the treatment of cancer. To contribute to development of new treatment…”
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Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress by Kotov, Ilya N., Siebring-van Olst, Ellen, Knobel, Philip A., van der Meulen-Muileman, Ida H., Felley-Bosco, Emanuela, van Beusechem, Victor W., Smit, Egbert F., Stahel, Rolf A., Marti, Thomas M.

“…REV3, the catalytic subunit of translesion polymerase zeta (polζ), is commonly associated with DNA damage bypass and repair. Despite sharing accessory subunits…”
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Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function by de Lange, Job, Faramarz, Atiq, Oostra, Anneke B., de Menezes, Renee X., van der Meulen, Ida H., Rooimans, Martin A., Rockx, Davy A., Brakenhoff, Ruud H., van Beusechem, Victor W., King, Randall W., de Winter, Johan P., Wolthuis, Rob M. F.

“…Warsaw breakage syndrome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion. Here, a paired genome-wide siRNA screen…”
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Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC by Nagel, Remco, Stigter-van Walsum, Marijke, Buijze, Marijke, van den Berg, Jaap, van der Meulen, Ida H, Hodzic, Jasmina, Piersma, Sander R, Pham, Thang V, Jiménez, Connie R, van Beusechem, Victor W, Brakenhoff, Ruud H

“…Lung cancer is the most common cancer worldwide and on top of that has a very poor prognosis, which is reflected by a 5-year survival rate of 5% to 15%…”
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Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition by Okonska, Agata, Bühler, Saskja, Rao, Vasundhara, Ronner, Manuel, Blijlevens, Maxime, van der Meulen-Muileman, Ida H, de Menezes, Renee X, Wipplinger, Martin, Oehl, Kathrin, Smit, Egbert F, Weder, Walter, Stahel, Rolf A, Penengo, Lorenza, van Beusechem, Victor W, Felley-Bosco, Emanuela

“…Loss of function of BRCA1-associated protein 1 (BAP1) is observed in about 50% of malignant pleural mesothelioma (MPM) cases. The aim of this study was to…”
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Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8 by Berenguer, Jordi, Lagerweij, Tonny, Zhao, Xi Wen, Dusoswa, Sophie, van der Stoop, Petra, Westerman, Bart, Gooijer, Mark C. de, Zoetemelk, Marloes, Zomer, Anoek, Crommentuijn, Matheus H. W., Wedekind, Laurine E., López-López, Àlan, Giovanazzi, Alberta, Bruch-Oms, Marina, Meulen-Muileman, Ida H. van der, Reijmers, Rogier M., van Kuppevelt, Toin H., García-Vallejo, Juan-Jesús, van Kooyk, Yvette, Tannous, Bakhos A., Wesseling, Pieter, Koppers-Lalic, Danijela, Vandertop, W. Peter, Noske, David P., van Beusechem, Victor W., van Rheenen, Jacco, Pegtel, D. Michiel, Tellingen, Olaf van, Wurdinger, Thomas

“…Cancer cells release extracellular vesicles (EVs) that contain functional biomolecules such as RNA and proteins. EVs are transferred to recipient cancer cells…”
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A genome‐wide si RNA screen for regulators of tumor suppressor p53 activity in human non‐small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment by Siebring‐van Olst, Ellen, Blijlevens, Maxime, de Menezes, Renee X., van der Meulen‐Muileman, Ida H., Smit, Egbert F., van Beusechem, Victor W.

“…Reinstating wild‐type tumor suppressor p53 activity could be a valuable option for the treatment of cancer. To contribute to development of new treatment…”
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Differential Effects of Combined Ad5-Δ24RGD and Radiation Therapy in In vitro versus In vivo Models of Malignant Glioma by Lamfers, Martine L.M., Idema, Sander, Bosscher, Lisette, Heukelom, Stan, Moeniralm, Sharif, van der Meulen-Muileman, Ida H., Overmeer, Renée M., van der Valk, Paul, van Beusechem, Victor W., Gerritsen, Winald R., Vandertop, W. Peter, Dirven, Clemens M.F.

“…Purpose: The integrin-targeted conditionally replicating adenovirus Ad5-Δ24RGD has been shown to possess strong oncolytic activity in experimental tumors and…”
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Differential effects of combined Ad5- delta 24RGD and radiation therapy in in vitro versus in vivo models of malignant glioma by Lamfers, Martine L M, Idema, Sander, Bosscher, Lisette, Heukelom, Stan, Moeniralm, Sharif, van der Meulen-Muileman, Ida H, Overmeer, Renée M, van der Valk, Paul, van Beusechem, Victor W, Gerritsen, Winald R, Vandertop, W Peter, Dirven, Clemens M F

“…The integrin-targeted conditionally replicating adenovirus Ad5-delta 24RGD has been shown to possess strong oncolytic activity in experimental tumors and is…”
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A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting by Hodzic, Jasmina, Dingjan, Ilse, Maas, Mariëlle Jp, van der Meulen-Muileman, Ida H, de Menezes, Renee X, Heukelom, Stan, Verheij, Marcel, Gerritsen, Winald R, Geldof, Albert A, van Triest, Baukelien, van Beusechem, Victor W

“…Radiotherapy is one of the mainstays in the treatment for cancer, but its success can be limited due to inherent or acquired resistance. Mechanisms underlying…”
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Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein by de Graaf, Michelle, Pinedo, Herbert M, Oosterhoff, Dinja, van der Meulen-Muileman, Ida H, Gerritsen, Winald R, Haisma, Hidde J, Boven, Epie

“…Tumor-specific activation of the glucuronide prodrug of doxorubicin, N-[4-doxorubicin-N-carbonyl(oxymethyl)phenyl]-O-beta-glucuronyl carbamate (DOX-GA3), by…”
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Expression of scFvs and scFv fusion proteins in eukaryotic cells by de Graaf, Michelle, van der Meulen-Muileman, Ida H, Pinedo, Herbert M, Haisma, Hidde J

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Abstract 4388: Genome-wide siRNA screens identify potent p53 inhibitors in NSCLC cells by Siebring-van Olst, Ellen, de Menezes, Renee X., van der Meulen, Ida H., Smit, Egbert F., van Beusechem, Victor W.

“…Abstract Background: Non Small Cell Lung Cancer (NSCLC) remains the number one cause of cancer death worldwide. For a number of cancers, restoration of tumor…”
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