Search Results - "van der Marel, Gijs"

(Automated) Synthesis of Well‐defined Staphylococcus Aureus Wall Teichoic Acid Fragments by Ali, Sara, Hendriks, Astrid, Dalen, Rob, Bruyning, Thomas, Meeuwenoord, Nico, Overkleeft, Herman S., Filippov, Dmitri V., Marel, Gijs A., Sorge, Nina M., Codée, Jeroen D. C.

“…Wall teichoic acids (WTAs) are important components of the cell wall of the opportunistic Gram‐positive bacterium Staphylococcus aureus. WTAs are composed of…”
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Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen by Li, Rui-Jun Eveline, Hogervorst, Tim P., Achilli, Silvia, Bruijns, Sven C., Arnoldus, Tim, Vivès, Corinne, Wong, Chung C., Thépaut, Michel, Meeuwenoord, Nico J., van den Elst, Hans, Overkleeft, Herman S., van der Marel, Gijs A., Filippov, Dmitri V., van Vliet, Sandra J., Fieschi, Franck, Codée, Jeroen D. C., van Kooyk, Yvette

“…Dendritic cells (DCs) are important initiators of adaptive immunity, and they possess a multitude of Pattern Recognition Receptors (PRR) to generate an…”
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Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens by Li, Rui-Jun Eveline, Hogervorst, Tim P., Achilli, Silvia, Bruijns, Sven C. M., Spiekstra, Sander, Vivès, Corinne, Thépaut, Michel, Filippov, Dmitri V., van der Marel, Gijs A., van Vliet, Sandra J., Fieschi, Franck, Codée, Jeroen D. C., van Kooyk, Yvette

“…Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207),…”
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Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides by Kistemaker, Hans A. V., Nardozza, Aurelio Pio, Overkleeft, Herman S., van der Marel, Gijs A., Ladurner, Andreas G., Filippov, Dmitri V.

“…Mono‐ADP‐ribosylation is a dynamic posttranslational modification (PTM) with important roles in signaling. Mammalian proteins that recognize or hydrolyze…”
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Inhibitors of protein: geranylgeranyl transferases by El Oualid, Farid, Cohen, Louis H, van der Marel, Gijs A, Overhand, Mark

“…The enzyme protein:geranylgeranyl transferase-1 (PGGT-1 or GGTase-I) catalyzes the geranylgeranylation of cysteine residues near the C-termini of a variety of…”
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A Multivalent Ligand for the Mannose-6-Phosphate Receptor for Endolysosomal Targeting of an Activity-Based Probe by Hoogendoorn, Sascha, van Puijvelde, Gijs H. M., Kuiper, Johan, van der Marel, Gijs A., Overkleeft, Herman S.

“…The ubiquitously expressed mannose‐6‐phosphate receptors (MPRs) are a promising class of receptors for targeted compound delivery into the endolysosomal…”
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Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses by Mangsbo, Sara M., Fletcher, Erika A.K., van Maren, Wendy W.C., Redeker, Anke, Cordfunke, Robert A., Dillmann, Inken, Dinkelaar, Jasper, Ouchaou, Kahina, Codee, Jeroen D.C., van der Marel, Gijs A., Hoogerhout, Peter, Melief, Cornelis J.M., Ossendorp, Ferry, Drijfhout, Jan W.

“…•Humoral responses against tetanus toxoid aid de novo generation of cellular immune responses.•A unique B cell epitope from tetanus toxin has been identified…”
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Synthetic Phenolic Glycolipids for Application in Diagnostic Tests for Leprosy by Dijk, J. Hessel M., Hooij, Anouk, Groot, L. Melanie, Geboers, Jolijn, Moretti, Rosita, Verhard‐Seymonsbergen, Els, Jong, Danielle, Marel, Gijs A., Corstjens, Paul L. A. M., Codée, Jeroen D. C., Geluk, Annemieke

“…Point‐of‐care (POC) diagnostic tests for the rapid detection of individuals infected with Mycobacterium leprae, the causative pathogen of leprosy, represent…”
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Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling by Willems, Lianne I, van der Linden, Wouter A, Li, Nan, Li, Kah-Yee, Liu, Nora, Hoogendoorn, Sascha, van der Marel, Gijs A, Florea, Bogdan I, Overkleeft, Herman S

“…The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After…”
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Quantification of globotriaosylsphingosine in plasma and urine of fabry patients by stable isotope ultraperformance liquid chromatography-tandem mass spectrometry by Gold, Henrik, Mirzaian, Mina, Dekker, Nick, Joao Ferraz, Maria, Lugtenburg, Johan, Codée, Jeroen D C, van der Marel, Gijs A, Overkleeft, Herman S, Linthorst, Gabor E, Groener, Johanna E M, Aerts, Johannes M, Poorthuis, Ben J H M

“…Biochemical markers that accurately reflect the severity and progression of disease in patients with Fabry disease and their response to treatment are urgently…”
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Developments in the Synthesis of Mycobacterial Phenolic Glycolipids by Hessel M. van Dijk, J., Marel, Gijs A., Codée, Jeroen D. C.

“…The highly lipophilic outer barrier of mycobacteria, such as M. tuberculosis and M. leprae, is key to their virulence and intrinsic antibiotic resistance…”
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A Cleavable Linker Based on the Levulinoyl Ester for Activity‐Based Protein Profiling by Geurink, Paul P., Florea, Bogdan I., Li, Nan, Witte, Martin D., Verasdonck, Joeri, Kuo, Chi‐Lin, van der Marel, Gijs A., Overkleeft, Herman S.

“…Get linked: The title linker is stable under various biological conditions and can be cleaved chemoselectively with hydrazine (see scheme). Its use is…”
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Influence of O6 in Mannosylations Using Benzylidene Protected Donors: Stereoelectronic or Conformational Effects? by Frihed, Tobias Gylling, Walvoort, Marthe T. C, Codée, Jeroen D. C, van der Marel, Gijs A, Bols, Mikael, Pedersen, Christian Marcus

“…The stereoselective synthesis of β-mannosides and the underlying reaction mechanism have been thoroughly studied, and especially the benzylidene-protected…”
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Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions by Speetjens, Frank M, Welters, Marij J P, Slingerland, Marije, van Poelgeest, Mariette I E, de Vos van Steenwijk, Peggy J, Roozen, Inge, Boekestijn, Sanne, Loof, Nikki M, Zom, Gijs G, Valentijn, A Rob P M, Krebber, Willem-Jan, Meeuwenoord, Nico J, Janssen, Catharina A H, Melief, Cornelis J M, van der Marel, Gijs A, Filippov, Dmitri V, van der Burg, Sjoerd H, Gelderblom, Hans, Ossendorp, Ferry

“…BackgroundAmplivant is a molecularly optimized Toll-like receptor 2 ligand that can be covalently conjugated to tumor peptide antigens. In preclinical models,…”
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Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates by Gential, Geoffroy P.P., Ho, Nataschja I., Chiodo, Fabrizio, Meeuwenoord, Nico, Ossendorp, Ferry, Overkleeft, Herman S., van der Marel, Gijs A., Filippov, Dmitri V.

“…[Display omitted] Chirally pure R- and S-epimers of TLR2 ligand Pam3CysSK4 were prepared and separately conjugated to an OVA model epitope, in which lysine was…”
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Exploring the Conformational and Biological Versatility of β-Turn-Modified Gramicidin S by Using Sugar Amino Acid Homologues that Vary in Ring Size by Knijnenburg, Annemiek D., Tuin, Adriaan W., Spalburg, Emile, de Neeling, Albert J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…Monobenzylated sugar amino acids (SAAs) that differ in ether ring size (containing an oxetane, furanoid, and pyranoid ring) were synthesized and incorporated…”
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An Adamantyl Amino Acid Containing Gramicidin S Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity by Kapoerchan, Varsha V., Knijnenburg, Annemiek D., Niamat, Miquel, Spalburg, Emile, de Neeling, Albert J., Nibbering, Peter H., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…The cyclic cationic antimicrobial peptide gramicidin S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis)…”
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Lipid A analog CRX-527 conjugated to synthetic peptides enhances vaccination efficacy and tumor control by Tondini, Elena, Reintjens, Niels R. M., Castello, Giulia, Arakelian, Tsolere, Isendoorn, Marjolein, Camps, Marcel, Vree, Jana, van der Marel, Gijs A., Filippov, Dmitri V., Codee, Jeroen D. C., Ossendorp, Ferry

“…Adjuvants play a determinant role in cancer vaccination by optimally activating APCs and shaping the T cell response. Bacterial-derived lipid A is one of the…”
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Photoaffinity labeling in activity-based protein profiling by Geurink, Paul P, Prely, Laurette M, van der Marel, Gijs A, Bischoff, Rainer, Overkleeft, Herman S

“…Activity-based protein profiling has come to the fore in recent years as a powerful strategy for studying enzyme activities in their natural surroundings…”
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Ph2SO/Tf2O:  a Powerful Promotor System in Chemoselective Glycosylations Using Thioglycosides by Codée, Jeroen D. C, Litjens, Remy E. J. N, den Heeten, René, Overkleeft, Herman S, van Boom, Jacques H, van der Marel, Gijs A

“…Diphenylsulfoxide in combination with triflic anhydride provides a very potent thiophilic glycosylation promotor system, capable of activating disarmed…”
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