The actual incidence of congenital adrenal hyperplasia in Brazil may not be as high as inferred--an estimate based on a public neonatal screening program in the state of Goiás

The incidence of 21-hydroxylase deficiency (CYP21 D) congenital adrenal hyperplasia (CAH) in Brazil is purportedly one of the highest in the world (1:7,533). However, this information is not based on official data. The aim of this study was to determine the incidence of CYP21 D CAH in the state of G...

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Bibliographic Details
Published in:	Journal of pediatric endocrinology & metabolism : JPEM Vol. 21; no. 5; p. 455
Main Authors:	Silveira, Elizabeth Lemos, dos Santos, Eliane Pereira, Bachega, Tânia A S, van der Linden Nader, Ivana, Gross, Jorge Luiz, Elnecave, Regina Helena
Format:	Journal Article
Language:	English
Published:	Germany 01-05-2008
Subjects:	17-alpha-Hydroxyprogesterone - blood Adrenal Hyperplasia, Congenital - blood Adrenal Hyperplasia, Congenital - diagnosis Adrenal Hyperplasia, Congenital - epidemiology Brazil - epidemiology Female Humans Incidence Infant Infant, Newborn Male Neonatal Screening - methods Reproducibility of Results Steroid 21-Hydroxylase - genetics
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Summary:	The incidence of 21-hydroxylase deficiency (CYP21 D) congenital adrenal hyperplasia (CAH) in Brazil is purportedly one of the highest in the world (1:7,533). However, this information is not based on official data. The aim of this study was to determine the incidence of CYP21 D CAH in the state of Goiás, Brazil, based on the 2005 results of government-funded mandatory screening. Of the live births during this period, 92.95% were screened by heel-prick capillary 17alpha-hydroxyprogesterone (17-OHP). Of these, 82,343 were normal, 28 were at high risk for CAH and 232 at low risk for CAH. Eight cases, all from the high risk group, were confirmed. Eight asymptomatic children at 6-18 months of age still have high 17-OHP levels and await diagnostic definition. Based on the number of confirmed CYP21 D CAH cases among the 82,603 screened, the estimated annual incidence of the disease was 1:10,325, lower than the previously reported rate in Brazil.
ISSN:	0334-018X
DOI:	10.1515/JPEM.2008.21.5.455