Search Results - "van der Linden, A"

Structure- and function-based design of Plasmodium-selective proteasome inhibitors by Li, Hao, O’Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew

“…Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human…”
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Pesticides in groundwater and drinking water wells: overview of the situation in the Netherlands by Schipper, P.N.M, Vissers, M.J.M

“…In the Netherlands, many of the fresh groundwater resources are vulnerable to pollution. Owing to high population densities and intensive farming practices,…”
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Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death by Sanman, Laura E, Qian, Yu, Eisele, Nicholas A, Ng, Tessie M, van der Linden, Wouter A, Monack, Denise M, Weerapana, Eranthie, Bogyo, Matthew

“…When innate immune cells such as macrophages are challenged with environmental stresses or infection by pathogens, they trigger the rapid assembly of…”
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Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection by Sanman, Laura E, van der Linden, Wouter A, Verdoes, Martijn, Bogyo, Matthew

“…Cysteine cathepsins are lysosomal proteases involved in regulation of both normal cellular processes and disease. Biochemical studies with peptide substrates…”
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LiGAPS-Beef, a mechanistic model to explore potential and feed-limited beef production 1: model description and illustration by van der Linden, A., van de Ven, G. W. J., Oosting, S. J., van Ittersum, M. K., de Boer, I. J. M.

“…The expected increase in the global demand for livestock products calls for insight in the scope to increase actual production levels across the world. This…”
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LiGAPS-Beef, a mechanistic model to explore potential and feed-limited beef production 2: sensitivity analysis and evaluation of sub-models by van der Linden, A., van de Ven, G. W. J., Oosting, S. J., van Ittersum, M. K., de Boer, I. J. M.

“…The model LiGAPS-Beef (Livestock simulator for Generic analysis of Animal Production Systems – Beef cattle) has been developed to assess potential and…”
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LiGAPS-Beef, a mechanistic model to explore potential and feed-limited beef production 3: model evaluation by van der Linden, A., van de Ven, G. W. J., Oosting, S. J., van Ittersum, M. K., de Boer, I. J. M.

“…LiGAPS-Beef (Livestock simulator for Generic analysis of Animal Production Systems – Beef cattle) is a generic, mechanistic model designed to quantify…”
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Towards Adaptive Grids for Atmospheric Boundary-Layer Simulations by van Hooft, J. Antoon, Popinet, Stéphane, van Heerwaarden, Chiel C., van der Linden, Steven J. A., de Roode, Stephan R., van de Wiel, Bas J. H.

“…We present a proof-of-concept for the adaptive mesh refinement method applied to atmospheric boundary-layer simulations. Such a method may form an attractive…”
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Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites by Hopp, Christine S, Bennett, Brandy L, Mishra, Satish, Lehmann, Christine, Hanson, Kirsten K, Lin, Jing-Wen, Rousseau, Kimberly, Carvalho, Filomena A, van der Linden, Wouter A, Santos, Nuno C, Bogyo, Matthew, Khan, Shahid M, Heussler, Volker, Sinnis, Photini

“…Proteases have been implicated in a variety of developmental processes during the malaria parasite lifecycle. In particular, invasion and egress of the…”
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Clinical impact of 20% worsening on Timed 25-foot Walk and 9-hole Peg Test in multiple sclerosis by Kragt, J J, van der Linden, F AH, Nielsen, J M, Uitdehaag, B MJ, Polman, C H

“…Introduction: Quantitative tests of motor function, like the Timed 25-foot Walk (T25FW) and 9-hole Peg Test (9HPT), are increasingly being applied as outcome…”
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Differential hippocampal gene expression is associated with climate-related natural variation in memory and the hippocampus in food-caching chickadees by Pravosudov, V. V., Roth II, T. C., Forister, M. L., LaDage, L. D., Kramer, R., Schilkey, F., van der Linden, A. M.

“…There is significant and often heritable variation in cognition and its underlying neural mechanisms, yet specific genetic contributions to such variation are…”
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Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination by Guglielmetti, C., Veraart, J., Roelant, E., Mai, Z., Daans, J., Van Audekerke, J., Naeyaert, M., Vanhoutte, G., Delgado y Palacios, R., Praet, J., Fieremans, E., Ponsaerts, P., Sijbers, J., Van der Linden, A., Verhoye, M.

“…Although MRI is the gold standard for the diagnosis and monitoring of multiple sclerosis (MS), current conventional MRI techniques often fail to detect…”
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Genomic monitoring to understand the emergence and spread of Usutu virus in the Netherlands, 2016–2018 by Oude Munnink, B. Bas, Münger, E., Nieuwenhuijse, D. F., Kohl, R., van der Linden, A., Schapendonk, C. M. E., van der Jeugd, H., Kik, M., Rijks, J. M., Reusken, C. B. E. M., Koopmans, M.

“…Usutu virus (USUV) is a mosquito-borne flavivirus circulating in Western Europe that causes die-offs of mainly common blackbirds ( Turdus merula ). In the…”
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Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease by Unger, M. S., Marschallinger, J., Kaindl, J., Höfling, C., Rossner, S., Heneka, Michael T., Van der Linden, A., Aigner, Ludwig

“…Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the Western world and is characterized by a progressive loss of cognitive functions…”
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Mapping Ground Water Vulnerability to Pesticide Leaching with a Process-Based Metamodel of EuroPEARL by Tiktak, A, Boesten, J.J.T.I, Linden, A.M.A. van der, Vanclooster, M

“…To support EU policy, indicators of pesticide leaching at the European level are required. For this reason, a metamodel of the spatially distributed European…”
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Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT by VASTENHOUW, B, VAN DER HAVE, F, VAN DER LINDEN, A. J. A, VON OERTHEL, L, BOOIJ, J, BURBACH, J. P. H, SMIDT, M. P, BEEKMAN, F. J

“…A pivotal question in neuropharmacology is how the function of neurotransmitter systems relates to psychiatric diseases. In experimental neuropharmacology, we…”
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Brain morphology in antipsychotic-naïve schizophrenia: A study of multiple brain structures by Cahn, W., Pol, H. E. Hulshoff, Bongers, M., Schnack, H. G., Mandl, R. C. W., Haren, N. E. M. Van, Durston, S., Koning, H., Van Der Linden, J. A., Kahn, R. S.

“…Although brain volume changes are found in schizophrenia, only a limited number of structural magnetic resonance imaging studies have exclusively examined…”
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Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases by Al Temimi, Abbas H K, White, Paul B, Mulders, Marcus J M, van der Linden, Nicole G A, Blaauw, Richard H, Wegert, Anita, Rutjes, Floris P J T, Mecinović, Jasmin

“…We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geometrically…”
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From Near-Neutral to Strongly Stratified: Adequately Modelling the Clear-Sky Nocturnal Boundary Layer at Cabauw by Baas, P., van de Wiel, B. J. H., van der Linden, S. J. A., Bosveld, F. C.

“…The performance of an atmospheric single-column model (SCM) is studied systematically for stably-stratified conditions. To this end, 11 years (2005–2015) of…”
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Influence of pH-dependent sorption and transformation on simulated pesticide leaching by van der Linden, A.M.A., Tiktak, A., Boesten, J.J.T.I., Leijnse, A.

“…The leaching of a substance is influenced by its physico-chemical characteristics as well as environmental conditions. In spatially distributed modelling the…”
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