Search Results - "van der Lee, Miranda M. C"

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985 by Elgersma, Ronald C, Coumans, Ruud G. E, Huijbregts, Tijl, Menge, Wiro M. P. B, Joosten, John A. F, Spijker, Henri J, de Groot, Franciscus M. H, van der Lee, Miranda M. C, Ubink, Ruud, van den Dobbelsteen, Diels J, Egging, David F, Dokter, Wim H. A, Verheijden, Gijs F. M, Lemmens, Jacques M, Timmers, C. Marco, Beusker, Patrick H

“…Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are predominantly based on two drug classes: auristatins and…”
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A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines by Coumans, Ruud G. E, Ariaans, Gerry J. A, Spijker, Henri J, Renart Verkerk, Pascal, Beusker, Patrick H, Kokke, Bas P. A, Schouten, Jan, Blomenröhr, Marion, van der Lee, Miranda M. C, Groothuis, Patrick G, Ubink, Ruud, Dokter, Wim H. A, Timmers, C. Marco

“…Engineering cysteines at specific sites in antibodies to create well-defined ADCs for the treatment of cancer is a promising approach to increase the…”
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SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody-Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression by Black, Jonathan, Menderes, Gulden, Bellone, Stefania, Schwab, Carlton L, Bonazzoli, Elena, Ferrari, Francesca, Predolini, Federica, De Haydu, Christopher, Cocco, Emiliano, Buza, Natalia, Hui, Pei, Wong, Serena, Lopez, Salvatore, Ratner, Elena, Silasi, Dan-Arin, Azodi, Masoud, Litkouhi, Babak, Schwartz, Peter E, Goedings, Peter, Beusker, Patrick H, van der Lee, Miranda M C, Timmers, C Marco, Dokter, Wim H A, Santin, Alessandro D

“…Uterine serous carcinoma (USC) is an aggressive form of endometrial cancer. Up to 35% of USC may overexpress the HER2/neu oncogene at strong (i.e., 3+) levels…”
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Chemokine cooperativity is caused by competitive glycosaminoglycan binding by Verkaar, Folkert, van Offenbeek, Jody, van der Lee, Miranda M C, van Lith, Lambertus H C J, Watts, Anne O, Rops, Angelique L W M M, Aguilar, David C, Ziarek, Joshua J, van der Vlag, Johan, Handel, Tracy M, Volkman, Brian F, Proudfoot, Amanda E I, Vischer, Henry F, Zaman, Guido J R, Smit, Martine J

“…Chemokines comprise a family of secreted proteins that activate G protein-coupled chemokine receptors and thereby control the migration of leukocytes during…”
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Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor by de Kruijf, Petra, van Heteren, Jane, Lim, Herman D, Conti, Paolo G M, van der Lee, Miranda M C, Bosch, Leontien, Ho, Koc-Kan, Auld, Douglas, Ohlmeyer, Michael, Smit, Martin J, Wijkmans, Jac C H M, Zaman, Guido J R, Smit, Martine J, Leurs, Rob

“…The chemokine receptor CXCR2 is involved in different inflammatory diseases, like chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and…”
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β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor by van der Lee, Miranda M.C., Verkaar, Folkert, Wat, Jesse W.Y., van Offenbeek, Jody, Timmerman, Martijn, Voorneveld, Lonneke, van Lith, Lambertus H.C.J., Zaman, Guido J.R.

“…Parathyroid hormone (PTH) is an anabolic agent that mediates bone formation through activation of the Gαs-, Gαq- and β-arrestin-coupled parathyroid hormone…”
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The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers by van der Lee, Miranda M C, Groothuis, Patrick G, Ubink, Ruud, van der Vleuten, Monique A J, van Achterberg, Tanja A, Loosveld, Eline M, Damming, Désirée, Jacobs, Daniëlle C H, Rouwette, Myrthe, Egging, David F, van den Dobbelsteen, Diels, Beusker, Patrick H, Goedings, Peter, Verheijden, Gijs F M, Lemmens, Jacques M, Timmers, Marco, Dokter, Wim H A

“…SYD985 is a HER2-targeting antibody-drug conjugate (ADC) based on trastuzumab and vc-seco-DUBA, a cleavable linker-duocarmycin payload. To evaluate the…”
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Pharmacological characterization of receptor redistribution and beta-arrestin recruitment assays for the cannabinoid receptor 1 by van der Lee, Miranda M C, Blomenröhr, Marion, van der Doelen, Antoon A, Wat, Jesse W Y, Smits, Niels, Hanson, Bonnie J, van Koppen, Chris J, Zaman, Guido J R

“…Receptor redistribution and beta-arrestin recruitment assays provide a G-protein-subtype-independent method to measure ligand-stimulated activation of…”
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Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody-Drug Conjugate by Groothuis, Patrick G, Jacobs, Daniëlle C H, Hermens, Inge A T, Damming, Désirée, Berentsen, Kim, Mattaar-Hepp, Ellen, Stokman, Marloes E M, Boekel, Tinie van, Rouwette, Myrthe, van der Vleuten, Monique A J, Sesink, Aloys, Dijcks, Fred A, Coumans, Ruud G E, Schouten, Jan, Glaudemans, Dirk H, Wijk, Daniëlle van, Blomenröhr, Marion, Kappers, Wendela A, Ubink, Ruud, van der Lee, Miranda M C, Dokter, Wim H A

“…MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive…”
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Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice by Ubink, Ruud, Dirksen, Eef H C, Rouwette, Myrthe, Bos, Ebo S, Janssen, Ingrid, Egging, David F, Loosveld, Eline M, van Achterberg, Tanja A, Berentsen, Kim, van der Lee, Miranda M C, Bichat, Francis, Raguin, Olivier, van der Vleuten, Monique A J, Groothuis, Patrick G, Dokter, Wim H A

“…Carboxylesterase 1c (CES1c) is responsible for linker-drug instability and poor pharmacokinetics (PK) of several antibody-drug conjugates (ADC) in mice, but…”
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Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist by Karstens, Willem F.J., M.B.P. Menge, Wiro, Martens, Gijs, op het Veld, Sanne J.N., Th.H. van Eupen, Jacobus, Demon, Marco, van Achterberg, Tanja A.E., Arisse-Thijssen, Monica J., Santegoeds-Lenssen, Ellen W.H., van der Lee, Miranda M.C., Ubink, Ruud, Arends, Roel J., Sesink, Aloys, Blomenröhr, Marion, Marco Timmers, C.

“…[Display omitted] •Discovery of a novel class of thyrotropin receptor antagonists.•A highly potent compound with oral efficacy was identified.•Risk of…”
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β-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR by Watts, Anne O., Verkaar, Folkert, van der Lee, Miranda M.C., Timmerman, Claudia A.W., Kuijer, Martien, van Offenbeek, Jody, van Lith, Lambertus H.C.J., Smit, Martine J., Leurs, Rob, Zaman, Guido J.R., Vischer, Henry F.

“…Chemokine receptors form a large subfamily of G protein-coupled receptors that predominantly activate heterotrimeric Gi proteins and are involved in immune…”
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beta-Arrestin recruitment assay for the identification of agonists of the sphingosine 1-phosphate receptor EDG1 by van Der Lee, Miranda M C, Bras, Maaike, van Koppen, Chris J, Zaman, Guido J R

“…beta-Arrestin recruitment assays provide a generic assay platform for drug discovery on G-protein-coupled receptors (GPCRs). The PathHunter assay technology…”
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1160 Phosphonate-antibody-drug conjugates: a novel immunostimulatory class of ADCs driving inside-out activation of Vγ9Vδ2 T cells leading to selective tumor cell killing by Helden, Mary J van, Elgersma, Ronald C, Kuppeveld, Daphne WJ van, Waalboer, Dennis, Damming, Désirée, Santegoeds-Lenssen, Ellen WH, Leenders, Inge, Laat-Arts, Karin de, Driessen-Engels, Lilian, Paradé, Marc CBC, Winkel, Menno, Scholzen, Anja, Wijk, Daniëlle EJW van, Dobbelsteen, Diels van den, Filiciotto, Genny, Assink, Laura, Rouwette, Myrthe, Spantidea, Panagiota I, Arends, Roel J, Berg, Timo K van den, Kappers, Wendela A, Verheijden, Gijs, Dokter, Wim HA, van der Lee, Miranda MC

“…BackgroundGamma delta (γδ) T cells are cytotoxic effector cells that can recognize and kill tumor cells in a major histocompatibility complex (MHC)-independent…”
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Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors by Zaman, Guido J R, van der Lee, Miranda M C, Kok, Jacobus J, Nelissen, Rob L H, Loomans, Elma E M G

“…The majority of protein kinase assays used in drug discovery research are enzyme activity assays. These assays are based on the measurement of phosphorylated…”
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