Search Results - "van der Lans, Sjors P. A."
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Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization
Published in Scientific reports (05-09-2024)“…The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant…”
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Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation
Published in Nature communications (16-09-2024)“…Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which…”
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Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing
Published in Scientific reports (03-08-2023)“…Due to multi-drug resistance, physicians increasingly use the last-resort antibiotic colistin to treat infections with the Gram-negative bacterium Klebsiella…”
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Longitudinal Fluctuations in Protein Concentrations and Higher-Order Structures in the Plasma Proteome of Kidney Failure Patients Subjected to a Kidney Transplant
Published in Journal of proteome research (07-06-2024)“…Using proteomics and complexome profiling, we evaluated in a year-long study longitudinal variations in the plasma proteome of kidney failure patients, prior…”
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Direct Mass Spectrometry-Based Detection and Antibody Sequencing of Monoclonal Gammopathy of Undetermined Significance from Patient Serum: A Case Study
Published in Journal of proteome research (01-09-2023)“…Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder characterized by the presence of a predominant monoclonal antibody (i.e.,…”
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