Search Results - "van der Laarse, A"

High residual cardiovascular risk after lipid-lowering: prime time for Predictive, Preventive, Personalized, Participatory, and Psycho-cognitive medicine by Reijnders, E., van der Laarse, A., Jukema, J. W., Cobbaert, C. M.

“…As time has come to translate trial results into individualized medical diagnosis and therapy, we analyzed how to minimize residual risk of cardiovascular…”
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Novel Approaches to Treat Experimental Pulmonary Arterial Hypertension : A Review by Umar, S., Steendijk, P., Ypey, D. L., Atsma, D. E., van der Wall, E. E., Schalij, M. J., van der Laarse, A.

“…Background. Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by an increase in pulmonary artery pressure leading to right…”
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Crosstalk between phosphorylation and O‐GlcNAcylation: friend or foe by Laarse, Saar A. M., Leney, Aneika C., Heck, Albert J. R.

“…A wide variety of protein post‐translational modifications (PTMs) decorate cellular proteins, regulating their structure, interactions and ultimately their…”
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Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation by Hessel, M. H. M., Atsma, D. E., van der Valk, E. J. M., Bax, W. H., Schalij, M. J., van der Laarse, A.

“…Elevated cardiac troponin-I (cTnI) levels have been demonstrated in serum of patients without acute coronary syndromes, potentially via a stretch-related…”
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Enhancing Top-Down Analysis Using Chromophore-Assisted Infrared Multiphoton Dissociation from (Phospho)peptides to Protein Assemblies by Greisch, Jean-François, van der Laarse, Saar A.M, Heck, Albert J.R

“…Infrared multiphoton dissociation (IRMPD) has been used in mass spectrometry to fragment peptides and proteins, providing fragments mostly similar to…”
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No Effect of C-Reactive Protein on Early Atherosclerosis Development in Apolipoprotein E3-Leiden/Human C-Reactive Protein Transgenic Mice by Trion, A, de Maat, M P.M, Jukema, J W, van der Laarse, A, Maas, M C, Offerman, E H, Havekes, L M, Szalai, A J, Princen, H M.G, Emeis, J J

“…OBJECTIVE—C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development…”
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Targeting proline in (phospho)proteomics by Laarse, Saar A. M., Gelder, Charlotte A. G. H., Bern, Marshall, Akeroyd, Michiel, Olsthoorn, Maurien M. A., Heck, Albert J. R.

“…Mass spectrometry‐based proteomics experiments typically start with the digestion of proteins using trypsin, chosen because of its high specificity,…”
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Hypothesis : Troponin degradation is one of the factors responsible for deterioration of left ventricular function in heart failure by VAN DER LAARSE, A

“…A hypothesis is presented that explains one of the mechanisms by which a heart starts to fail. The hypothesis is that myocardial function of an overloaded or…”
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Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent by Umar, S, van der Valk, E. J. M, Schalij, M. J, van der Wall, E. E, Atsma, D. E, van der Laarse, A

“…Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin…”
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Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention by Monraats, P S, Kurreeman, F A S, Pons, D, Sewgobind, V D K D, de Vries, F R, Zwinderman, A H, de Maat, M P M, Doevendans, P A, de Winter, R J, Tio, R A, Waltenberger, J, Huizinga, T W J, Eefting, D, Quax, P H A, Frants, R R, van der Laarse, A, van der Wall, E E, Jukema, J W

“…Genetic factors appear to be important in the process of restenosis after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal…”
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Mechanical stress stimulates phospholipase C activity and intracellular calcium ion levels in neonatal rat cardiomyocytes by Ruwhof, C., van Wamel, J.E.T., Noordzij, L.A.W., Aydin, S., Harper, J.C.R., van der Laarse, A.

“…To investigate how mechanical stress is sensed by cardiomyocytes and translated to cardiac hypertrophy, cardiomyocytes were subjected to stretch while…”
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Irradiation of mechanically-injured human arterial endothelial cells leads to increased gene expression and secretion of inflammatory and growth promoting cytokines by Wondergem, J., Wedekind, L.E., Bart, C.I., Chin, A., van der Laarse, A., Beekhuizen, H.

“…Radiation therapy is applied to inhibit neointima formation after percutaneous transluminal coronary angioplasty (PTCA). In this study, we evaluated the effect…”
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Association of baseline apolipoprotein B and friedewald LDLC with long-term re-infarction in hypertriglyceridemic patients with ST-segment elevation myocardial infarction by Hermans, M, van der Laarse, A, Schalij, M, Romijn, F, Smit, N, van der Burgt, Y, Jukema, W, Cobbaert, C

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Preservation of left ventricular function and attenuation of remodeling after transplantation of human epicardium-derived cells into the infarcted mouse heart by WINTER, E. M, GRAUSS, R. W, STEENDIJK, P, DOEVENDANS, P. A, VAN DER LAARSE, A, POELMANN, R. E, SCHALIJ, M. J, ATSMA, D. E, GITTENBERGER-DE GROOT, A. C, HOGERS, B, VAN TUYN, J, VAN DER GEEST, R, LIE-VENEMA, H, VICENTE STEIJN, R, MAAS, S, DERUITER, M. C, DEVRIES, A. A. F

“…Proper development of compact myocardium, coronary vessels, and Purkinje fibers depends on the presence of epicardium-derived cells (EPDCs) in embryonic…”
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Implication of fibrate therapy for homocysteine by Jonkers, IJAM, de Man, FHAF, Onkenhout, W, van der Laarse, A, Smelt, AHM

“…To identify a possible effect of bezafibrate on renal function, serum creatinine was assessed, 24 h urine was collected for measurement of urinary creatinine,…”
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Quantitation of global and regional left ventricular function by cine magnetic resonance imaging during dobutamine stress in normal human subjects by van Rugge, F P, Holman, E R, van der Wall, E E, de Roos, A, van der Laarse, A, Bruschke, A V

“…Magnetic resonance imaging (MRI) provides high-resolution images of the heart. However, physical exercise during MRI is difficult due to space restriction and…”
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Separation of neonatal rat ventricular myocytes and non-myocytes by centrifugal elutriation by Boerma, M, van der Wees, C G C, Wondergem, J, van der Laarse, A, Persoon, M, van Zeeland, A A, Mullenders, L H F

“…The preparation of pure cardiac myocyte cultures from neonatal rats is hampered by the presence of non-myocytes, which can proliferate during culturing,…”
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TCT-493 The Clinical Utility of High-Sensitive Troponin T to Predict Infarct Size, Left Ventricular Function and Adverse Outcome in Patients with First ST Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention by Boden, H, Ahmed, T.A.N, Velders, M.A, van der Hoeven, B.L, Hoogslag, G.E, Bootsma, M, le Cessie, S, Cobbaert, C.M, van der Laarse, A, Schalij, M.J

“…With the addition of hs-cTnT values separately to multivariate regression models, all were independent predictors of Q48CK, WMSI and LVEF but hs-cTnT24 was…”
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Release kinetics of intact and degraded troponin I and T after irreversible cell damage by Hessel, M.H.M., Michielsen, E.C.H.J., Atsma, D.E., Schalij, M.J., van der Valk, E.J.M., Bax, W.H., Hermens, W.T., van Dieijen-Visser, M.P., van der Laarse, A.

“…We characterized the release kinetics of cardiac troponin I and T in relation to lactate dehydrogenase (LDH) from cardiomyocytes before and after the…”
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Morphometric quantification of myocyte dimensions validated in normal growing rat hearts and applied to hypertrophic human hearts by Vliegen, H W, van der Laarse, A, Huysman, J A, Wijnvoord, E C, Mentar, M, Cornelisse, C J, Eulderink, F

“…To obtain quantitative information on changes in myocyte size in hearts with increased myocardial mass light microscopical morphometry was used in fixed and…”
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