Search Results - "van der Laan, Jan"

Structural and time‐resolved mechanistic investigations of protein hydrolysis by the acidic proline‐specific endoprotease from Aspergillus niger by Pijning, Tjaard, Vujičić‐Žagar, Andreja, Laan, Jan‐Metske, Jong, René M., Ramirez‐Palacios, Carlos, Vente, Andre, Edens, Luppo, Dijkstra, Bauke W.

“…Proline‐specific endoproteases have been successfully used in, for example, the in‐situ degradation of gluten, the hydrolysis of bitter peptides, the reduction…”
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Directed Evolution Strategies for Enantiocomplementary Haloalkane Dehalogenases: From Chemical Waste to Enantiopure Building Blocks by van Leeuwen, Jan G. E., Wijma, Hein J., Floor, Robert J., van der Laan, Jan-Metske, Janssen, Dick B.

“…We used directed evolution to obtain enantiocomplementary haloalkane dehalogenase variants that convert the toxic waste compound 1,2,3‐trichloropropane (TCP)…”
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Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'-authors' reply by Vandebriel, Rob J, De Jong, Hilda J I, Gremmer, Eric R, Klungel, Olaf H, Tervaert, Jan-Willem Cohen, Slob, Wout, Van Der Laan, Jan W, Van Loveren, Henk

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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum by McLean, Kirsty J, Hans, Marcus, Meijrink, Ben, van Scheppingen, Wibo B, Vollebregt, Aad, Tee, Kang Lan, van der Laan, Jan-Metske, Leys, David, Munro, Andrew W, van den Berg, Marco A

“…The cholesterol-lowering blockbuster drug pravastatin can be produced by stereoselective hydroxylation of the natural product compactin. We report here the…”
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Optical simulation of monolithic scintillator detectors using GATE/GEANT4 by van der Laan, D J Jan, Schaart, Dennis R, Maas, Marnix C, Beekman, Freek J, Bruyndonckx, Peter, van Eijk, Carel W E

“…Much research is being conducted on position-sensitive scintillation detectors for medical imaging, particularly for emission tomography. Monte Carlo…”
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Limits on the spatial resolution of monolithic scintillators read out by APD arrays by van der Laan, D J Jan, Maas, Marnix C, Bruyndonckx, Peter, Schaart, Dennis R

“…Cramér-Rao theory can be used to derive the lower bound on the spatial resolution achievable with position-sensitive scintillation detectors as a function of…”
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The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations by Forster, Roy, Bode, Gerd, Ellegaard, Lars, van der Laan, Jan-Willem

“…The objective of the RETHINK project was to evaluate the potential impact of toxicity testing in the minipig as an alternative approach in regulatory toxicity…”
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Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme by Bokhove, Marcel, Yoshida, Hiromi, Hensgens, Charles M.H., Metske van der Laan, Jan, Sutherland, John D., Dijkstra, Bauke W.

“…Penicillium chrysogenum Acyl coenzyme A:isopenicillin N acyltransferase (AT) performs the last step in the biosynthesis of hydrophobic penicillins, exchanging…”
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An integrative test strategy for cancer hazard identification by Luijten, Mirjam, Olthof, Evelyn D., Hakkert, Betty C., Rorije, Emiel, van der Laan, Jan-Willem, Woutersen, Ruud A., van Benthem, Jan

“…Assessment of genotoxic and carcinogenic potential is considered one of the basic requirements when evaluating possible human health risks associated with…”
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Revision of ICH S8 Needed? by Van Der Laan, Jan Willem

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Monolithic scintillator PET detectors with intrinsic depth-of-interaction correction by Maas, Marnix C, Schaart, Dennis R, van der Laan, D J Jan, Bruyndonckx, Peter, Lemaître, Cedric, Beekman, Freek J, van Eijk, Carel W E

“…We developed positron emission tomography (PET) detectors based on monolithic scintillation crystals and position-sensitive light sensors. Intrinsic…”
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Peroxicretion: a novel secretion pathway in the eukaryotic cell by Sagt, Cees M J, ten Haaft, Peter J, Minneboo, Ingeborg M, Hartog, Miranda P, Damveld, Robbert A, van der Laan, Jan Metske, Akeroyd, Michiel, Wenzel, Thibaut J, Luesken, Francisca A, Veenhuis, Marten, van der Klei, Ida, de Winde, Johannes H

“…Enzyme production in microbial cells has been limited to secreted enzymes or intracellular enzymes followed by expensive down stream processing. Extracellular…”
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Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals by Heusinkveld, Harm, Braakhuis, Hedwig, Gommans, Robin, Botham, Phil, Corvaro, Marco, van der Laan, Jan Willem, Lewis, Dick, Madia, Federica, Manou, Irene, Schorsch, Frédéric, Wolterink, Gerrit, Woutersen, Ruud, Corvi, Raffaella, Mehta, Jyotigna, Luijten, Mirjam

“…Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health…”
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Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals by Beken, Sonja, Kasper, Peter, van der Laan, Jan-Willem

“…Animal studies may be carried out to support first administration of a new medicinal product to either humans or the target animal species, or before…”
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A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals by Luijten, Mirjam, Corvi, Raffaella, Mehta, Jyotigna, Corvaro, Marco, Delrue, Nathalie, Felter, Susan, Haas, Bodo, Hewitt, Nicola J., Hilton, Gina, Holmes, Thomas, Jacobs, Miriam N., Jacobs, Abigail, Lamplmair, Franz, Lewis, Dick, Madia, Federica, Manou, Irene, Melching-Kollmuss, Stephanie, Schorsch, Frederic, Schütte, Katrin, Sewell, Fiona, Strupp, Christian, van der Laan, Jan Willem, Wolf, Douglas C., Wolterink, Gerrit, Woutersen, Ruud, Zvonar, Zvonimir, Heusinkveld, Harm, Braakhuis, Hedwig

“…Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies…”
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Identification of Requirements for Computer-Supported Matching of Food Consumption Data with Food Composition Data by Koroušić Seljak, Barbara, Korošec, Peter, Eftimov, Tome, Ocke, Marga, van der Laan, Jan, Roe, Mark, Berry, Rachel, Crispim, Sandra Patricia, Turrini, Aida, Krems, Carolin, Slimani, Nadia, Finglas, Paul

“…This paper identifies the requirements for computer-supported food matching, in order to address not only national and European but also international current…”
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Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production by Ter Braak, Bas, Siezen, Christine L, Lee, Joo S, Rao, Pooja, Voorhoeve, Charlotte, Ruppin, Eytan, van der Laan, Jan Willem, van de Water, Bob

“…The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several…”
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Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products by van der Laan, Jan Willem, Brightwell, John, McAnulty, Peter, Ratky, Joszef, Stark, Claudia

“…As part of the RETHINK European FP6 Project an overview of the acceptability and usefulness of minipigs has been carried out in the regulatory arenas of human…”
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Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence by Bronsveld, Heleen K, ter Braak, Bas, Karlstad, Øystein, Vestergaard, Peter, Starup-Linde, Jakob, Bazelier, Marloes T, De Bruin, Marie L, de Boer, Anthonius, Siezen, Christine L E, van de Water, Bob, van der Laan, Jan Willem, Schmidt, Marjanka K

“…Several studies have suggested that anti-diabetic insulin analogue treatment might increase cancer risk. The aim of this study was to review the postulated…”
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Towards a continuous crystal APD-based PET detector design by Bruyndonckx, Peter, Lemaître, Cedric, Schaart, Dennis, Maas, Marnix, van der Laan, D.J. (jan), Krieguer, Magalie, Devroede, Olivier, Tavernier, Stefaan

“…Monolithic scintillator blocks provide an efficient way to significantly increase the sensitivity of high-resolution positron emission tomography (PET)…”
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