Search Results - "van der Kemp, Annemiete"

TRPM6 Forms the Mg2+ Influx Channel Involved in Intestinal and Renal Mg2+ Absorption by Voets, Thomas, Nilius, Bernd, Hoefs, Susan, van der Kemp, Annemiete W.C.M., Droogmans, Guy, Bindels, Rene J.M., Hoenderop, Joost G.J.

“…Mg2+ is an essential ion involved in a multitude of physiological and biochemical processes and a major constituent of bone tissue. Mg2+ homeostasis in mammals…”
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Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney by NIJENHUIS, Tom, HOENDEROP, Joost G. J, VAN DER KEMP, Annemiete W. C. M, BINDELS, René J. M

“…The family of epithelial Ca(2+) channels consists of two highly homologues members, TRPV5 and TRPV6, which constitute the apical Ca(2+) entry mechanism in…”
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Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6 by van Abel, Monique, Huybers, Sylvie, Hoenderop, Joost G J, van der Kemp, Annemiete W C M, van Leeuwen, Johannes P T M, Bindels, René J M

“…Aging is associated with alterations in Ca2+ homeostasis, which predisposes elder people to hyperparathyroidism and osteoporosis. Intestinal Ca2+ absorption…”
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Coordinated control of renal Ca2+ transport proteins by parathyroid hormone by van Abel, Monique, Hoenderop, Joost G.J., van der Kemp, Annemiete W.C.M., Friedlaender, Michael M., van Leeuwen, Johannes P.T.M., Bindels, René J.M.

“…Coordinated control of renal Ca2+ transport proteins by parathyroid hormone. The kidney is one of the affected organs involved in the clinical symptoms of…”
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Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity by Schoeber, Joost P. H., Topala, Catalin N., Lee, Kyu Pil, Lambers, Tim T., Ricard, Guénola, van der Kemp, Annemiete W. C. M., Huynen, Martijn A., Hoenderop, Joost G. J., Bindels, René J. M.

“…The transient receptor potential vanilloid channels 5 and 6 (TRPV5/6) are the most Ca 2+ -selective channels within the TRP superfamily of ion channels. These…”
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Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice by van Angelen, Annelies A, Glaudemans, Bob, van der Kemp, AnneMiete W C M, Hoenderop, Joost G J, Bindels, René J M

“…Cisplatin is an effective anti-neoplastic drug, but its clinical use is limited due to dose-dependent nephrotoxicity. The majority of cisplatin-treated…”
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Calcitriol controls the epithelial calcium channel in kidney by HOENDEROP, Joost G. J, MÜLLER, Dominik, BINDELS, René J. M, VAN DER KEMP, Annemiete W. C. M, HARTOG, Anita, SUZUKI, Makoto, ISHIBASHI, Kenichi, IMAI, Masashi, SWEEP, Fred, WILLEMS, Peter H. G. M, VAN OS, Carel H

“…The recently cloned epithelial Ca2+ channel (ECaC), which is expressed primarily in 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))-responsive Ca2+ -transporting…”
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Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia by Nijenhuis, Tom, Vallon, Volker, van der Kemp, Annemiete W C M, Loffing, Johannes, Hoenderop, Joost G J, Bindels, René J M

“…Thiazide diuretics enhance renal Na+ excretion by blocking the Na+-Cl- cotransporter (NCC), and mutations in NCC result in Gitelman syndrome. The mechanisms…”
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Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity by VAN DE GRAAF, Stan F. J, VAN DER KEMP, Annemiete W. C. M, VAN DEN BERG, Dennis, VAN OORSCHOT, Mijke, HOENDEROP, Joost G. J, BINDELS, René J. M

“…Transient receptor potential vallinoid 5 (TRPV5) and TRPV6 are the most Ca2+-selective members of the TRP superfamily and are essential for active Ca2+…”
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Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney by Nijenhuis, Tom, Hoenderop, Joost G.J., Loffing, Johannes, van der Kemp, Annemiete W.C.M., van Os, Carel H., Bindels, René J.M.

“…Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Thiazide diuretics have the unique characteristic…”
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The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent Nephrolithiasis by RENKEMA, Kirsten Y, VELIC, Ana, HOENDEROP, Joost G, DIJKMAN, Henry B, VERKAART, Sjoerd, VAN DER KEMP, Annemiete W, NOWIK, Marta, TIMMERMANS, Kim, DOUCET, Alain, WAGNER, Carsten A, BINDELS, René J

“…Hypercalciuria increases the risk for urolithiasis, but renal adaptive mechanisms reduce this risk. For example, transient receptor potential vanilloid 5…”
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A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia by Glaudemans, Bob, van der Wijst, Jenny, Scola, Rosana H, Lorenzoni, Paulo J, Heister, Angelien, van der Kemp, Annemiete W, Knoers, Nine V, Hoenderop, Joost G, Bindels, René J

“…Primary hypomagnesemia is a heterogeneous group of disorders characterized by renal or intestinal magnesium (Mg2+) wasting, resulting in tetany, cardiac…”
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Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia by Woudenberg-Vrenken, Titia E, Sukinta, Arjaree, van der Kemp, Annemiete W, Bindels, René J M, Hoenderop, Joost G J

“…Hypomagnesemia with secondary hypocalcemia is due to disturbed renal and intestinal magnesium (Mg(2+)) (re)absorption. The underlying defect is a mutation in…”
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Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice by RENKEMA, Kirsten Y, NIJENHUIS, Tom, VAN DER EERDEN, Bram C. J, VAN DER KEMP, Annemiete W. C. M, WEINANS, Harrie, VAN LEEUWEN, Johannes P. T. M, BINDELS, René J. M, HOENDEROP, Joost G. J

“…Vitamin D plays an important role in Ca(2+) homeostasis by controlling Ca(2+) (re)absorption in intestine, kidney, and bone. The epithelial Ca(2+) channel…”
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Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice by GKIKA, Dimitra, HSU, Yu-Juei, VAN DER KEMP, Annemiete W, CHRISTAKOS, Sylvia, BINDELS, René J, HOENDEROP, Joost G

“…The epithelial Ca(2+) channel TRPV5 facilitates apical Ca(2+) entry during active Ca(2+) reabsorption in the distal convoluted tubule. In this process,…”
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Functional implications of mutations in the human renal outer medullary potassium channel (ROMK2) identified in Bartter syndrome by Starremans, Patrick G J F, van der Kemp, Annemiete W C M, Knoers, Nine V A M, van den Heuvel, Lambertus P W J, Bindels, René J M

“…Bartter syndrome is an autosomal recessive heterogeneous renal tubular disorder affecting NaCl reabsorption in the thick ascending limb of Henle's loop (TAL)…”
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Characterization of vitamin D-deficient klotho―/― mice: do increased levels of serum 1,25(OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho―/― mice? by WOUDENBERG-VRENKEN, Titia E, DER EERDEN, Bram C. J. Van, DER KEMP, Annemiete W. C. M. Van, LEEUWEN, Johannes P. T. M. Van, BINDELS, Rene J. M, HOENDEROP, Joost G. J

“…Klotho(-/-) mice display disturbed Ca(2+) and vitamin D homeostasis. Renal cytochrome p450 27b1 (Cyp27b1), the enzyme that catalyzes the hydrolysis to…”
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Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4 by van de Graaf, Stan F J, Hoenderop, Joost G J, van der Kemp, Annemiete W C M, Gisler, Serge M, Bindels, René J M

“…The epithelial Ca(2+) channels TRPV5 and TRPV6 constitute the apical Ca(2+) influx pathway in epithelial Ca(2+) transport. PDZ proteins have been demonstrated…”
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Coordinated control of renal Ca transport proteins by parathyroid hormone by van Abel, Monique, Hoenderop, Joost G J, van der Kemp, Annemiete W C M, Friedlaender, Michael M, van Leeuwen, Johannes P T M, Bindels, René J M

“…The kidney is one of the affected organs involved in the clinical symptoms of parathyroid hormone (PTH)-related disorders, like primary hyperparathyroidism and…”
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Methionine Sulfoxide Reductase B1 (MsrB1) Recovers TRPM6 Channel Activity during Oxidative Stress by Cao, Gang, Lee, Kyu pil, van der Wijst, Jenny, de Graaf, Mark, van der Kemp, AnneMiete, Bindels, René J.M., Hoenderop, Joost G.J.

“…Mg2+ is an essential ion for many cellular processes, including protein synthesis, nucleic acid stability, and numerous enzymatic reactions. Mg2+ homeostasis…”
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