Search Results - "van der Harst, Johanneke E."

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates by Manfré, Giuseppe, Novati, Arianna, Faccini, Ilaria, Rossetti, Andrea C, Bosch, Kari, Molteni, Raffaella, Riva, Marco A, Van der Harst, Johanneke E, Nguyen, Huu Phuc, Homberg, Judith R

“…Huntington disease (HD) is a devastating inherited neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms without…”
Get full text

The BACHD Rat Model of Huntington Disease Shows Specific Deficits in a Test Battery of Motor Function by Manfré, Giuseppe, Clemensson, Erik K H, Kyriakou, Elisavet I, Clemensson, Laura E, van der Harst, Johanneke E, Homberg, Judith R, Nguyen, Huu Phuc

“…: Huntington disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and neuropsychiatric symptoms. HD is usually diagnosed…”
Get full text

Validation of behavioral phenotypes in the BACHD rat model by Novati, Arianna, Manfré, Giuseppe, Flunkert, Stefanie, Van der Harst, Johanneke E., Homberg, Judith R., Wronski, Robert, Nguyen, Huu Phuc

“…•Validation of behavioral readouts is essential for preclinical research.•The reproducibility of BACHD rats’ phenotypes was assessed.•BACHD rats’ motor and…”
Get full text

Home-cage anxiety levels in a transgenic rat model for Spinocerebellar ataxia type 17 measured by an approach-avoidance task: The light spot test by Kyriakou, Elisavet I., Nguyen, Huu Phuc, Homberg, Judith R., Van der Harst, Johanneke E.

“…•Light spot used for measuring anxiety in the home cage for the first time in rats.•Light spot caused an initial increase in activity and time spent in the…”
Get full text

Reproducibility and relevance of future behavioral sciences should benefit from a cross fertilization of past recommendations and today's technology: “Back to the future” by Spruijt, Berry M., Peters, Suzanne M., de Heer, Raymond C., Pothuizen, Helen H.J., van der Harst, Johanneke E.

“…•Standard behavioral tests have limited validity and lack reproducibility.•Advanced methods and technologies are available, but marginally applied.•The lack of…”
Get full text

Short- and long-term behavioral analysis of social interaction, ultrasonic vocalizations and social motivation in a chronic phencyclidine model by Peters, Suzanne M., Tuffnell, Joe A., Pinter, Ilona J., van der Harst, Johanneke E., Spruijt, Berry M.

“…•Short and long term effects of chronic PCP were examined.•On short term, social interaction behavior was negatively affected by PCP.•PCP could not induce a…”
Get full text

Automated quantitative analysis to assess motor function in different rat models of impaired coordination and ataxia by Kyriakou, Elisavet I., van der Kieft, Jan G., de Heer, Raymond C., Spink, Andrew, Nguyen, Huu Phuc, Homberg, Judith R., van der Harst, Johanneke E.

“…•Design and validation of a CatWalk protocol based on repeated testing and rewards.•Enriched housed rats show higher walking and swing speed and longer stride…”
Get full text

Novel approach to automatically classify rat social behavior using a video tracking system by Peters, Suzanne M., Pinter, Ilona J., Pothuizen, Helen H.J., de Heer, Raymond C., van der Harst, Johanneke E., Spruijt, Berry M.

“…•Current animal models, if involving social behavior at all, are limited to very short and simple measurements.•Social behavior is mostly manually annotated,…”
Get full text

Characterization of anticipatory behaviour in domesticated horses (Equus caballus) by Peters, Suzanne M., Bleijenberg, Elise H., van Dierendonck, Machteld C., van der Harst, Johanneke E., Spruijt, Berry M.

“…In animal welfare science there is a strong need for objective parameters for the assessment of animal welfare. Anticipatory behaviour is a potential indicator…”
Get full text

A Sustained Depressive State Promotes a Guanfacine Reversible Susceptibility to Alcohol Seeking in Rats by RIGA, Danai, SCHMITZ, Leanne J. M, VAN DER HARST, Johanneke E, VAN MOURIK, Yvar, HOOGENDIJK, Witte J. G, SMIT, August B, DE VRIES, Taco J, SPIJKER, Sabine

“…High rates of comorbidity between alcohol use disorder (AUD) and major depressive disorder (MDD) are reported. Preclinical models examining effects of primary…”
Get full text

Anxiety and risk assessment-related traits in a rat model of Spinocerebellar ataxia type 17 by Kyriakou, Elisavet I., Manfré, Giuseppe, Spadaro, Jesús A., Nguyen, Huu Phuc, Harst, Johanneke E.Van der, Homberg, Judith R.

“…Anxiety as a common feature of several neurodegenerative/polyglutamine diseases is an important aspect for the face validity of an animal model for…”
Get full text

An automated system for the recognition of various specific rat behaviours by van Dam, Elsbeth A., van der Harst, Johanneke E., ter Braak, Cajo J.F., Tegelenbosch, Ruud A.J., Spruijt, Berry M., Noldus, Lucas P.J.J.

“…•Automated recognition of the rat behaviours ‘drink’, ‘eat’, ‘sniff’, ‘groom’, ‘jump’, ‘rear unsupported’, ‘rear wall’, ‘rest’, ‘twitch’ and ‘walk’ from…”
Get full text

Standard housed rats are more sensitive to rewards than enriched housed rats as reflected by their anticipatory behaviour by van der Harst, Johanneke E., Baars, Anne-Marie, Spruijt, Berry M.

“…The present study was designed to investigate the effects of potentially stressful standard housing conditions for laboratory rats on the sensitivity to…”
Get full text

Announced reward counteracts the effects of chronic social stress on anticipatory behavior and hippocampal synaptic plasticity in rats by Kamal, Amer, Van der Harst, Johanneke E, Kapteijn, Chantal M, Baars, Annemarie J. M, Spruijt, Berry M, Ramakers, Geert M. J

“…Chronic stress causes insensitivity to rewards (anhedonia) in rats, reflected by the absence of anticipatory behavior for a sucrose-reward, which can be…”
Get full text

Announced rewards counteract the impairment of anticipatory behaviour in socially stressed rats by van der Harst, Johanneke E., Baars, Anne-Marie, Spruijt, Berry M.

“…It is known that stress can influence the sensitivity to rewarding stimuli. Previous observations revealed that socially stressed rats do not display an…”
Get full text

Anticipation is differently expressed in rats ( Rattus norvegicus) and domestic cats ( Felis silvestris catus) in the same Pavlovian conditioning paradigm by Bos, Ruud van den, Meijer, Margot K., van Renselaar, Jaline P., van der Harst, Johanneke E., Spruijt, Berry M.

“…In rats ( Rattus norvegicus) anticipation to an oncoming food reward in an appetitive Pavlovian conditioning procedure is expressed as an increase of…”
Get full text

Corrigendum to “An automated system for the recognition of various specific rat behaviors” [J. Neurosci. Methods 218(2) (2013) 214–224] by van Dam, Elsbeth A., van der Harst, Johanneke E., ter Braak, Cajo J.F., Tegelenbosch, Ruud A.J., Spruijt, Berry M., Noldus, Lucas P.J.J.

Get full text