Search Results - "van der Ham, Alwin J."

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses by Kaisar, Maria M M, Ritter, Manuel, Del Fresno, Carlos, Jónasdóttir, Hulda S, van der Ham, Alwin J, Pelgrom, Leonard R, Schramm, Gabriele, Layland, Laura E, Sancho, David, Prazeres da Costa, Clarissa, Giera, Martin, Yazdanbakhsh, Maria, Everts, Bart

“…The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain…”
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Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling by Kaisar, Maria M M, Pelgrom, Leonard R, van der Ham, Alwin J, Yazdanbakhsh, Maria, Everts, Bart

“…Recently, it has become clear that short-chain fatty acids (SCFAs), and in particular butyrate, have anti-inflammatory properties. Murine studies have shown…”
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Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor by Everts, Bart, Hussaarts, Leonie, Driessen, Nicole N, Meevissen, Moniek H J, Schramm, Gabriele, van der Ham, Alwin J, van der Hoeven, Barbara, Scholzen, Thomas, Burgdorf, Sven, Mohrs, Markus, Pearce, Edward J, Hokke, Cornelis H, Haas, Helmut, Smits, Hermelijn H, Yazdanbakhsh, Maria

“…Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to…”
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Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses by Everts, Bart, Perona-Wright, Georgia, Smits, Hermelijn H, Hokke, Cornelis H, van der Ham, Alwin J, Fitzsimmons, Colin M, Doenhoff, Michael J, van der Bosch, Jürgen, Mohrs, Katja, Haas, Helmut, Mohrs, Markus, Yazdanbakhsh, Maria, Schramm, Gabriele

“…Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo…”
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LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells by Pelgrom, Leonard R., Patente, Thiago A., Sergushichev, Alexey, Esaulova, Ekaterina, Otto, Frank, Ozir-Fazalalikhan, Arifa, van der Zande, Hendrik J. P., van der Ham, Alwin J., van der Stel, Stefan, Artyomov, Maxim N., Everts, Bart

“…Liver Kinase B1 (LKB1) plays a key role in cellular metabolism by controlling AMPK activation. However, its function in dendritic cell (DC) biology has not…”
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Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro by van Schuijlenburg, Roos, Azargoshasb, Samaneh, de Korne, Clarize M, Sijtsma, Jeroen C, Bezemer, Sascha, van der Ham, Alwin J, Baalbergen, Els, Geurten, Fiona, de Bes-Roeleveld, Laura M, Chevalley-Maurel, Severine C, van Oosterom, Matthias N, van Leeuwen, Fijs W B, Franke-Fayard, Blandine, Roestenberg, Meta

“…Sporozoites (SPZ), the infective form of Plasmodium falciparum malaria, can be inoculated into the human host skin by Anopheline mosquitoes. These SPZ migrate…”
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mTORC1 signaling in antigen-presenting cells of the skin restrains CD8+ T cell priming by Pelgrom, Leonard R., Patente, Thiago A., Otto, Frank, Nouwen, Lonneke V., Ozir-Fazalalikhan, Arifa, van der Ham, Alwin J., van der Zande, Hendrik J.P., Heieis, Graham A., Arens, Ramon, Everts, Bart

“…How mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism, affects dendritic cell (DC) metabolism and T cell-priming…”
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DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells by Kuipers, Marije E., Nolte-'t Hoen, Esther N.M., van der Ham, Alwin J., Ozir-Fazalalikhan, Arifa, Nguyen, D. Linh, de Korne, Clarize M., Koning, Roman I., Tomes, John J., Hoffmann, Karl F., Smits, Hermelijn H., Hokke, Cornelis H.

“…Helminths like Schistosoma mansoni release excretory/secretory (E/S) products that modulate host immunity to enable infection. Extracellular vesicles (EVs) are…”
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Differences in innate cytokine responses between European and African children by Labuda, Lucja A, de Jong, Sanne E, Meurs, Lynn, Amoah, Abena S, Mbow, Moustapha, Ateba-Ngoa, Ulysse, van der Ham, Alwin J, Knulst, André C, Yazdanbakhsh, Maria, Adegnika, Ayola A

“…Although differences in immunological responses between populations have been found in terms of vaccine efficacy, immune responses to infections and prevalence…”
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C-Reactive Protein Promotes Inflammation through FcγR-Induced Glycolytic Reprogramming of Human Macrophages by Newling, Melissa, Sritharan, Lathees, van der Ham, Alwin J, Hoepel, Willianne, Fiechter, Renée H, de Boer, Leonie, Zaat, Sebastian A J, Bisoendial, Radjesh J, Baeten, Dominique L P, Everts, Bart, den Dunnen, Jeroen

“…C-reactive protein (CRP) is an acute-phase protein produced in high quantities by the liver in response to infection and during chronic inflammatory disorders…”
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IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming by Hoepel, Willianne, Allahverdiyeva, Sona, Harbiye, Haneen, de Taeye, Steven W, van der Ham, Alwin J, de Boer, Leonie, Zaat, Sebastiaan A J, van Weeghel, Michel, Baeten, Dominique L P, Houtkooper, Riekelt H, Everts, Bart, Vidarsson, Gestur, den Dunnen, Jeroen

“…IgG Abs are crucial for various immune functions, including neutralization, phagocytosis, and Ab-dependent cellular cytotoxicity. In this study, we identified…”
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AMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism by Brombacher, Eline C, Patente, Thiago A, van der Ham, Alwin J, Moll, Tijmen J A, Otto, Frank, Verheijen, Fenne W M, Zaal, Esther A, de Ru, Arnoud H, Tjokrodirijo, Rayman T N, Berkers, Celia R, van Veelen, Peter A, Guigas, Bruno, Everts, Bart

“…Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to…”
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Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma by Besse, Lenka, Besse, Andrej, Stolze, Sara C, Sobh, Amin, Zaal, Esther A, van der Ham, Alwin J, Ruiz, Mario, Phuyal, Santosh, Büchler, Lorina, Sathianathan, Marc, Florea, Bogdan I, Borén, Jan, Ståhlman, Marcus, Huber, Julia, Bolomsky, Arnold, Ludwig, Heinz, Hannich, J Thomas, Loguinov, Alex, Everts, Bart, Berkers, Celia R, Pilon, Marc, Farhan, Hesso, Vulpe, Christopher D, Overkleeft, Herman S, Driessen, Christoph

“…The HIV-protease inhibitor nelfinavir has shown broad anticancer activity in various preclinical and clinical contexts. In patients with advanced, proteasome…”
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Rapamycin and omega‐1: mTOR‐dependent and ‐independent Th2 skewing by human dendritic cells by Hussaarts, Leonie, Smits, Hermelijn H, Schramm, Gabriele, Ham, Alwin J, Zon, Gerard C, Haas, Helmut, Guigas, Bruno, Yazdanbakhsh, Maria

“…Recent reports have attributed an immunoregulatory role to the mammalian target of rapamycin (mTOR), a key serine/threonine protein kinase integrating input…”
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Nelfinavir Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma By Modulating Membrane Lipid Bilayer Composition and Fluidity by Besse, Andrej, Besse, Lenka, Stolze, Sara C., Sobh, Amin, Zaal, Esther A., van der Ham, Alwin J, Ruiz, Mario, Phuyal, Santosh, Büchler, Lorina, Sathianathan, Marc, Florea, Bogdan I., Borén, Jan, Ståhlman, Marcus, Loguinov, Alex, Everts, Bart, Berkers, Celia R., Pilon, Marc, Farhan, Hesso, Vulpe, Chris D., Overkleeft, Herman S., Driessen, Christoph

“…INTRODUCTION Nelfinavir is a highly lipophilic, first generation HIV-protease inhibitor (HIV-PI) approved for HIV treatment. It has largely been replaced by…”
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Dectin-1/2-induced autocrine PGE.sub.2 signaling licenses dendritic cells to prime Th2 responses by Kaisar, Maria M. M, Ritter, Manuel, del Fresno, Carlos, Jónasdóttir, Hulda S, van der Ham, Alwin J, Pelgrom, Leonard R, Schramm, Gabriele, Layland, Laura E, Sancho, David, Prazeres da Costa, Clarissa, Giera, Martin, Yazdanbakhsh, Maria, Everts, Bart

“…The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain…”
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Analysis of TLR-Induced Metabolic Changes in Dendritic Cells Using the Seahorse XF(e)96 Extracellular Flux Analyzer by Pelgrom, Leonard R, van der Ham, Alwin J, Everts, Bart

“…Engagement of Toll-like receptors (TLRs) on dendritic cells (DCs) triggers the expression of a large set of genes involved in DC activation and maturation,…”
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