Search Results - "van der Eerden, Bram C J"

Sexual dimorphisms in serum calcium and phosphate concentrations in the Rotterdam Study by Bosman, Ariadne, Koek, W. Nadia H., Campos-Obando, Natalia, van der Eerden, Bram C. J., Ikram, M. A., Uitterlinden, André G., van Leeuwen, Johannes P. T. M., Zillikens, M. C.

“…Sex differences in serum phosphate and calcium have been reported but the exact nature and underlying regulatory mechanisms remain unclear. We aimed to compare…”
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An Age-Dependent Interaction with Leptin Unmasks Ghrelin's Bone-Protective Effects by van der Velde, Martijn, van der Eerden, Bram C.J, Sun, Yuxiang, Almering, Julia M.M, van der Lely, Aart-Jan, Delhanty, Patric J.D, Smith, Roy G, van Leeuwen, Johannes P.T.M

“…The mutual interplay between energy homeostasis and bone metabolism is an important emerging concept. Ghrelin and leptin antagonize each other in regulating…”
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Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway by Brum, Andrea M., van de Peppel, Jeroen, van der Leije, Cindy S., Schreuders-Koedam, Marijke, Eijken, Marco, van der Eerden, Bram C. J., van Leeuwen, Johannes P. T. M.

“…Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. In this study, we…”
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Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects by Franken, Gijs A. C., Seker, Murat, Bos, Caro, Siemons, Laura A. H., van der Eerden, Bram C. J., Christ, Annabel, Hoenderop, Joost G. J., Bindels, René J. M., Müller, Dominik, Breiderhoff, Tilman, de Baaij, Jeroen H. F.

“…Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is…”
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FAM111A is dispensable for electrolyte homeostasis in mice by Ilenwabor, Barnabas P., Schigt, Heidi, Kompatscher, Andreas, Bos, Caro, Zuidscherwoude, Malou, van der Eerden, Bram C. J., Hoenderop, Joost G. J., de Baaij, Jeroen H. F.

“…Autosomal dominant mutations in FAM111A are causative for Kenny-Caffey syndrome type 2. Patients with Kenny-Caffey syndrome suffer from severe growth…”
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Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study by Waqas, Komal, Chen, Jinluan, van der Eerden, Bram C J, Ikram, M Arfan, Uitterlinden, André G, Voortman, Trudy, Zillikens, M Carola

“…Animal studies suggest a role for dietary advanced glycation end-products (dAGEs) in bone health, but human studies on dAGEs in relation to bone are lacking…”
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HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis by Zhang, Shuang, van de Peppel, Jeroen, Koedam, Marijke, van Leeuwen, Johannes P T M, van der Eerden, Bram C J

“…Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells…”
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IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation by Razawy, Wida, Alves, Celso H., Koedam, Marijke, Asmawidjaja, Patrick S., Mus, Adriana M. C., Oukka, Mohamed, Leenen, Pieter J. M., Visser, Jenny A., van der Eerden, Bram C. J., Lubberts, Erik

“…The IL-23 receptor (IL-23R) signaling pathway has pleiotropic effects on the differentiation of osteoclasts and osteoblasts, since it can inhibit or stimulate…”
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Zika virus infects human osteoclasts and blocks differentiation and bone resorption by Mumtaz, Noreen, Koedam, Marijke, van Leeuwen, Johannes P. T. M., Koopmans, Marion P. G., van der Eerden, Bram C. J., Rockx, Barry

“…Bone-related complications are commonly reported following arbovirus infection. These arboviruses are known to disturb bone-remodeling and induce inflammatory…”
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Osteocalcin-A Versatile Bone-Derived Hormone by Moser, Sarah C, van der Eerden, Bram C J

“…Bone has long been regarded as a static organ, simply providing protection and support. However, this mindset has changed radically in recent years and bone is…”
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Genetic Manipulation of the Ghrelin Signaling System in Male Mice Reveals Bone Compartment Specificity of Acylated and Unacylated Ghrelin in the Regulation of Bone Remodeling by Delhanty, Patric J. D, van der Velde, Martijn, van der Eerden, Bram C. J, Sun, Yuxiang, Geminn, Julia M. M, van der Lely, Aart-Jan, Smith, Roy G, van Leeuwen, Johannes P. T. M

“…Ghrelin receptor-deficient (Ghsr−/−) mice that lack acylated ghrelin (AG) signaling retain a metabolic response to unacylated ghrelin (UAG). Recently, we…”
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Bone Resorption Inhibitor Alendronate Normalizes the Reduced Bone Thickness of TRPV5−/− Mice by Nijenhuis, Tom, van der Eerden, Bram CJ, Hoenderop, Joost GJ, Weinans, Harrie, van Leeuwen, Johannes PTM, Bindels, René JM

“…TRPV5 is a Ca2+‐selective channel involved in transcellular Ca2+ absorption expressed in kidney and in the ruffled border of osteoclasts. Studies in…”
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The Epithelial Ca2+Channel TRPV5 Is Essential for Proper Osteoclastic Bone Resorption by Bram C. J. van der Eerden, Joost G. J. Hoenderop, Teun J. de Vries, Ton Schoenmaker, Cok J. Buurman, Uitterlinden, André G., Huibert A. P. Pols, René J. M. Bindels, Johannes P. T. M. van Leeuwen, DeLuca, Hector F.

“…Bone remodeling involves the interplay of bone resorption and formation and is accurately controlled to maintain bone mass. Both processes require…”
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A role for sirtuin 1 in FGF23 activation following β-glycerophosphate treatment by Ratsma, Danielle M. A., Muller, Max, Koedam, Marijke, Zillikens, M. Carola, van der Eerden, Bram C. J.

“…Phosphate homeostasis is vital for many biological processes and disruptions in circulating levels can be detrimental. While the mechanisms behind FGF23…”
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Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells by Zhang, Shuang, van de Peppel, Jeroen, Koedam, Marijke, van Leeuwen, Johannes P. T. M., van der Eerden, Bram C. J.

“…Background The tightly controlled balance between osteogenic and adipogenic differentiation of human bone marrow-derived stromal cells (BMSCs) is critical to…”
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Loss of Anti-Müllerian Hormone Signaling in Mice Affects Trabecular Bone Mass in a Sex- and Age-Dependent Manner by van As, Christiane, Koedam, Marijke, McLuskey, Anke, Kramer, Piet, Lahlou, Najiba, van der Eerden, Bram C J, Visser, Jenny A

“…Abstract Ovariectomy-induced osteoporosis in mice results from an abrupt loss of ovarian sex steroids. Anti-Müllerian hormone knockout (AMHKO) mice show a…”
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Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials by Šalandová, Monika, Hengel, Ingmar A. J., Apachitei, Iulian, Zadpoor, Amir A., Eerden, Bram C. J., Fratila‐Apachitei, Lidy E.

“…Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone…”
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Human mesenchymal stromal cells in adhesion to cell‐derived extracellular matrix and titanium: Comparative kinome profile analysis by Baroncelli, Marta, Fuhler, Gwenny M., Peppel, Jeroen, Zambuzzi, Willian F., Leeuwen, Johannes P., Eerden, Bram C. J., Peppelenbosch, Maikel P.

“…The extracellular matrix (ECM) physically supports cells and influences stem cell behaviour, modulating kinase‐mediated signalling cascades. Cell‐derived ECMs…”
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Expanding the Phenotypic Spectrum of Kenny–Caffey Syndrome by Schigt, Heidi, Bald, Martin, van der Eerden, Bram C J, Gal, Lars, Ilenwabor, Barnabas P, Konrad, Martin, Levine, Michael A, Li, Dong, Mache, Christoph J, Mackin, Sharon, Perry, Colin, Rios, Francisco J, Schlingmann, Karl Peter, Storey, Ben, Trapp, Christine M, Verkerk, Annemieke J M H, Zillikens, M Carola, Touyz, Rhian M, Hoorn, Ewout J, Hoenderop, Joost G J, de Baaij, Jeroen H F

“…Abstract Context Kenny–Caffey syndrome (KCS) is a rare hereditary disorder characterized by short stature, hypoparathyroidism, and electrolyte disturbances…”
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Fibronectin in Fracture Healing: Biological Mechanisms and Regenerative Avenues by Klavert, Jonathan, van der Eerden, Bram C J

“…The importance of extracellular matrix (ECM) proteins in mediating bone fracture repair is evident, and fibronectin (FN) has emerged as a pivotal regulator of…”
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